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双碘喹啉

双碘喹啉用途

Diiodohydroxyquinoline是一种局部用治疗剂,具有较好的抗菌特性。

双碘喹啉名称

[ CAS 号 ]:
83-73-8

[ 中文名 ]:
5,7-二碘-8-羟基喹啉

[ 英文名 ]:
Diiodohydroxyquinoline

[中文别名 ]:

[英文别名 ]:

Disoquin
Dyodin
Rafamebin
ZOAQUIN
Diiodo-oxyquinoline
8-Hydroxy-5,7-diiodoquinoline
EINECS 201-497-9
Searlequin
5,7-diiodoquinolin-8-ol
Yodoxin

双碘喹啉生物活性

[ 描述 ]:

Diiodohydroxyquinoline是一种局部用治疗剂,具有较好的抗菌特性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

双碘喹啉物理化学性质

[ 密度 ]:
2.5±0.1 g/cm3

[ 沸点 ]:
401.8±45.0 °C at 760 mmHg

[ 熔点 ]:
>200 °C (dec.)(lit.)

[ 分子式 ]:
C₉H₅I₂NO

[ 分子量 ]:
396.951

[ 闪点 ]:
196.8±28.7 °C

[ 精确质量 ]:
396.846039

[ PSA ]:
33.12000

[ LogP ]:
4.11

[ 外观性状 ]:
黄色到褐色粉末，晶体和/或块状

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.828

[ 储存条件 ]:
室温

双碘喹啉MSDS

双碘喹啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VC5775000

CHEMICAL NAME :: 8-Quinolinol, 5,7-diiodo-

CAS REGISTRY NUMBER :: 83-73-8

BEILSTEIN REFERENCE NO. :: 0153639

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C9-H5-I2-N-O

MOLECULAR WEIGHT :: 396.95

WISWESSER LINE NOTATION :: T66 BNJ GI II JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 819 mg/kg/13D-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Blood - oxidant related (GPD deficient) anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 120 gm/kg/2Y-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - visual field changes

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >40 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 50 mg/kg

TOXIC EFFECTS :: Liver - other changes

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,219,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80403 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)

双碘喹啉安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
3

[ RTECS号 ]:
VC5775000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2933499090

双碘喹啉合成路线

双碘喹啉制备

由8-羟基喹啉经碘化而得。

双碘喹啉海关

[ 海关编码 ]: 2933499090

[ 中文概述 ]:
2933499090. 其他含喹琳或异喹啉环系的化合物〔但未进一步稠合的〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

双碘喹啉文献

Effects of oral administration of zinc and diiodohydroxyquinolein on plasma zinc levels of uremic patients.

Nephron 69(2) , 147-50, (1995)

Patients with chronic renal failure often have low plasma zinc (Zn) levels. Some factors that may account for abnormal Zn metabolism in these patients are low dietary Zn intake, a specific Zn transpor...

Chromatographic methods for simultaneous determination of diiodohydroxyquinoline and metronidazole in their binary mixture.

Pak. J. Pharm. Sci. 26(5) , 865-71, (2013)

Two chromatographic methods were developed for analysis ofdiiodohydroxyquinoline (DIHQ) and metronidazole (MTN). In the first method, diiodohydroxyquinoline and metronidazole were separated on TLC sil...

LC of pharmaceutically important halogenated 8-hydroxyquinolines after precolumn derivatization with Pd (II).

J. Pharm. Biomed. Anal. 27(5) , 813-20, (2002)

An accurate, sensitive, and selective reversed phase high performance liquid chromatographic (HPLC) method was developed for the analysis of two halogenated 8-hydroxyquinoline derivatives; clioquinol ...

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