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四氢唑啉

四氢唑啉用途

Tetrahydrozoline 是一种有效的甲肾上腺素能 (α-adrenergic) 激动剂,可引起血管收缩。再动物实验模型中,Tetrahydrozoline 可有效缓解结膜充血、眼充血和鼻充血。

四氢唑啉名称

[ CAS 号 ]:
84-22-0

[ 中文名 ]:
四氢唑林

[ 英文名 ]:
Tetrahydrozoline

[中文别名 ]:

[英文别名 ]:

四氢唑啉生物活性

[ 描述 ]:

Tetrahydrozoline 是一种有效的甲肾上腺素能 (α-adrenergic) 激动剂,可引起血管收缩。再动物实验模型中,Tetrahydrozoline 可有效缓解结膜充血、眼充血和鼻充血。

[ 相关类别 ]:

研究领域 >> 心血管疾病
信号通路 >> G 蛋白偶联受体/G 蛋白 >> 肾上腺素能受体

[参考文献]

[1]. E Kisilevsky, et al. Anterior and posterior segment vasculopathy associated with long-term use of tetrahydrozoline. CMAJ. 2018 Oct 9;190(40):E1208.

[2]. Judy Peat, et al.Determination of tetrahydrozoline in urine and blood using gas chromatography-mass spectrometry (GC-MS). Methods Mol Biol

四氢唑啉物理化学性质

[ 密度 ]:
1.2 g/cm3

[ 沸点 ]:
393.5ºC at 760 mmHg

[ 分子式 ]:
C13H16N2

[ 分子量 ]:
200.28000

[ 闪点 ]:
191.8ºC

[ 精确质量 ]:
200.13100

[ PSA ]:
24.39000

[ LogP ]:
1.87260

[ 外观性状 ]:
粉末

[ 折射率 ]:
1.656

[ 储存条件 ]:
-20℃

四氢唑啉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ4525000
CHEMICAL NAME :
2-Imidazoline, 2-(1,2,3,4-tetrahydro-1-naphthyl)-
CAS REGISTRY NUMBER :
84-22-0
BEILSTEIN REFERENCE NO. :
0011442
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C13-H16-N2
MOLECULAR WEIGHT :
200.31
WISWESSER LINE NOTATION :
L66&TJ G- BT5M CN BUTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
186 nL/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 2,217,1984
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
150 ug/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - hallucinations, distorted perceptions Behavioral - irritability
REFERENCE :
AEMED3 Annals of Emergency Medicine. (American College of Emergency Physicians, 1125 Executive Circle, Irving, TX 75038) Volume(issue)/page/year: 20,655,1991
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Human - infant
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - coma Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,580,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - child
DOSE/DURATION :
375 nL/kg
TOXIC EFFECTS :
Behavioral - wakefulness Behavioral - somnolence (general depressed activity)
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 2,217,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
335 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
116 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
252 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
48100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,699,1990

四氢唑啉合成路线

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：45-二氢-2-(1234-四氢-1-萘基)-1H-咪唑

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥381.9/50mg ￥205.9/1ml ￥2327.9/1g ￥931.9/250mg

联系人：阿拉丁

产品详情：替曲唑啉

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥515.0/5mg

联系人：夏言

产品详情：[Perfemiker]四氢唑林,GR

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