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醋碘苯酸

醋碘苯酸用途

Acetrizoic acid 是一种小分子化合物,被用作显影剂。

醋碘苯酸名称

[ CAS 号 ]:
85-36-9

[ 中文名 ]:
醋碘苯酸

[ 英文名 ]:
Acetrizoic Acid

[中文别名 ]:

[英文别名 ]:

MFCD00016495
3-(acetylamino)-2,4,6-triiodobenzoic acid
Benzoic acid, 3-(acetylamino)-2,4,6-triiodo-
EINECS 201-600-7
UNII:24256BQV7M
3-Acetamido-2,4,6-triiodobenzoic acid

醋碘苯酸生物活性

[ 描述 ]:

Acetrizoic acid 是一种小分子化合物,被用作显影剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 其他

[参考文献]

[1]. CHEN Xing-ming, et al. Comparison of side effects between acetrizoic acid and omnipaque during interventional therapy. Journal of Foshan University (Natural Science Edition), 2008-06

[2]. LV Xiao-qin, et al. Statistical Analysis of 153 Cases Manifesting Adverse Reactions Caused by Acetrizoic Acid. Chinese Journal of Modern Applied Pharmacy, 2008-01

[相关活性小分子]

醋碘苯酸物理化学性质

[ 密度 ]:
2.8±0.1 g/cm3

[ 沸点 ]:
547.1±50.0 °C at 760 mmHg

[ 分子式 ]:
C₉H₆I₃NO₃

[ 分子量 ]:
556.862

[ 闪点 ]:
284.7±30.1 °C

[ 精确质量 ]:
556.748169

[ PSA ]:
66.40000

[ LogP ]:
1.04

[ 外观性状 ]:
白色结晶粉末，溶于水。熔点278-283℃

[ 蒸汽压 ]:
0.0±1.5 mmHg at 25°C

[ 折射率 ]:
1.802

[ 储存条件 ]:
室温，干燥

醋碘苯酸MSDS

详细MSDS(安全技术说明书)

醋碘苯酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG0887000

CHEMICAL NAME :: Benzoic acid, 3-acetamido-2,4,6-triiodo-

CAS REGISTRY NUMBER :: 85-36-9

BEILSTEIN REFERENCE NO. :: 2219129

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C9-H6-I3-N-O3

MOLECULAR WEIGHT :: 556.86

WISWESSER LINE NOTATION :: QVR BI DI FI CMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 42,721,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 20 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 18,33,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 18,33,1963

醋碘苯酸安全信息

[ 风险声明 (欧洲) ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ RTECS号 ]:
DG0887000

[ 海关编码 ]:
2924299090

醋碘苯酸合成路线

详细合成路线

醋碘苯酸制备

3-氨基-2，4，6-三碘苯甲酸钠（见02780）乙酰化而得：先后将乙酐、硫酸加入反应罐，冷却至40℃后加入3-氨基-2,4，6-三碘笨甲酸钠。升温，于80℃反应3小时。冷却至室温，甩滤，用蒸馏水洗，得醋碘笨酸粗品。将粗品加水和EDTA搅拌1小时，过滤，用水冲洗4次。再将醋碘苯酸加入罐内，用氨水调节pH至8.5。过滤，用95%乙醇反复泡洗，滤去乙醇，得醋碘苯酸铵。将其溶解于蒸馏水，加活性炭脱色过滤，滤液用3N盐酸调节pH至1，再过滤，用50℃热蒸馏水洗至无氯离子，烘干，得醋碘苯酸。

醋碘苯酸海关

[ 海关编码 ]: 2924299090

[ 中文概述 ]:
2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%