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TCO-OH

TCO-OH用途

TCO-OH 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

TCO-OH名称

[ CAS 号 ]:
85081-69-2

[ 中文名 ]:
(E)-环辛-4-烯醇

[ 英文名 ]:
TCO-OH

[英文别名 ]:

(E)-CYCLOOCT-4-ENOL
4-Cycloocten-1-ol, (E)-
(E)-Cyclooct-4-enol

TCO-OH生物活性

[ 描述 ]:

TCO-OH 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

TCO-OH物理化学性质

[ 分子式 ]:
C₈H₁₄O

[ 分子量 ]:
126.19600

[ 精确质量 ]:
126.10400

[ PSA ]:
20.23000

[ LogP ]:
1.86760

[ 外观性状 ]:
液体

[ 储存条件 ]:
20°C

TCO-OH安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H318

[ 警示性声明 ]:
P280-P305 + P351 + P338

[ 危害码 (欧洲) ]:
C

[ 风险声明 (欧洲) ]:
41-52

[ 安全声明 (欧洲) ]:
26-39

[ 危险品运输编码 ]:
NONH for all modes of transport

TCO-OH文献

Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation.

Bioconjug. Chem. 22 , 2263-2270, (2011)

1,2,4,5-Tetrazines have been established as effective dienes for inverse electron demand [4 + 2] Diels-Alder cycloaddition reactions with strained alkenes for over 50 years. Recently, this reaction pa...

Tetrazine-based cycloadditions: application to pretargeted live cell imaging.

Bioconjug. Chem. 19 , 2297-2299, (2008)

Bioorthogonal tetrazine cycloadditions have been applied to live cell labeling. Tetrazines react irreversibly with the strained dienophile norbornene forming dihydropyrazine products and dinitrogen. T...

Tetrazine ligation: fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity.

J. Am. Chem. Soc. 130 , 13518-13519, (2008)

Described is a bioorthogonal reaction that proceeds with unusually fast reaction rates without need for catalysis: the cycloaddition of s-tetrazine and trans-cyclooctene derivatives. The reactions tol...

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