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半齿泽兰素

半齿泽兰素用途

Eupatorin 是一种天然存在的黄酮,可捕获 G2-M 细胞周期,并通过激活多个 caspase,细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解诱导凋亡细胞死亡。

半齿泽兰素名称

[ CAS 号 ]:
855-96-9

[ 中文名 ]:
3,5-二羟基-4,6,7-三甲氧基黄酮

[ 英文名 ]:
Eupatorin

[中文别名 ]:

半齿泽兰素

[英文别名 ]:

MFCD00016929
3',5-dihydroxy-4',6,7-trimethoxyflavone
eupatorin
6-methoxyluteolin-4',7-dimethyl ether

半齿泽兰素生物活性

[ 描述 ]:

Eupatorin 是一种天然存在的黄酮,可捕获 G2-M 细胞周期,并通过激活多个 caspase,细胞色素 C 的释放、多聚 (ADP-核糖) 聚合酶的裂解诱导凋亡细胞死亡。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Estévez S, et al. Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway. PLoS One. 2014 Nov 12;9(11):e112536.

半齿泽兰素物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
587.0±50.0 °C at 760 mmHg

[ 熔点 ]:
194-196°C

[ 分子式 ]:
C₁₈H₁₆O₇

[ 分子量 ]:
344.315

[ 闪点 ]:
216.0±23.6 °C

[ 精确质量 ]:
344.089600

[ PSA ]:
98.36000

[ LogP ]:
2.96

[ 外观性状 ]:
黄色粉末

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.627

[ 储存条件 ]:
room temp

半齿泽兰素安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301

[ 警示性声明 ]:
P301 + P310

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

[ 海关编码 ]:
2932999099

半齿泽兰素上下游产品

半齿泽兰素上游产品

半齿泽兰素下游产品

半齿泽兰素海关

[ 海关编码 ]: 2932999099

[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

半齿泽兰素文献

Analysis of vervain flavonoids by HPLC/Diode array detector method. Its application to quality control.

J. Agric. Food Chem. 47(11) , 4579-82, (1999)

A reversed-phase HPLC procedure is proposed for the determination of seven flavonoids (luteolin, nepetin, hispidulin, jaceosidin, cirsimaritin, cirsilineol, and eupatorin) in vervain samples. A simple...

Flavones and rosmarinic acid from Salvia limbata.

Nat. Prod. Res. 24(20) , 1902-6, (2010)

The genus Salvia (Lamiaceae) contains more than 50 shrub species in Iran, and Salvia limbata C.A. Meyer grows widely in the north and central parts of the country. Six flavones and rosmarinic acid wer...

Flavonoids eupatorin and sinensetin present in Orthosiphon stamineus leaves inhibit inflammatory gene expression and STAT1 activation.

Planta Med. 78(8) , 779-86, (2012)

Cytokines and other inflammatory mediators, such as prostaglandin E₂ (PGE₂) and nitric oxide (NO) produced by cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), respectively, activat...

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