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乙氧甲叉

乙氧甲叉用途

【用途一】
一种分子中含有多种活性基团的重要有机原料，能与多种物质进行缩聚和环化缩合，现主要用于合成氟哌酸
【用途二】
有机合成原料，用于医药、染料等产品制造。

乙氧甲叉名称

[ CAS 号 ]:
87-13-8

[ 中文名 ]:
乙氧基甲叉丙二酸二乙酯

[ 英文名 ]:
Diethyl ethoxymethylenemalonate

[中文别名 ]:

[英文别名 ]:

2OVYVO2&U1O2
Diethyl ethoxymethylenemalonate
Diethyl (ethoxymethylene)malonate
diethyl 2-(ethoxymethylidene)propanedioate
EINECS 201-725-7
MFCD00009148

乙氧甲叉物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
280.0±0.0 °C at 760 mmHg

[ 熔点 ]:
-33°C

[ 分子式 ]:
C₁₀H₁₆O₅

[ 分子量 ]:
216.231

[ 闪点 ]:
155.0±0.0 °C

[ 精确质量 ]:
216.099777

[ PSA ]:
61.83000

[ LogP ]:
1.44

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.447

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
insoluble

乙氧甲叉MSDS

乙氧甲叉毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OO1100000

CHEMICAL NAME :: Malonic acid, (ethoxymethylene)-, diethyl ester

CAS REGISTRY NUMBER :: 87-13-8

BEILSTEIN REFERENCE NO. :: 0880058

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C10-H16-O5

MOLECULAR WEIGHT :: 216.26

WISWESSER LINE NOTATION :: 2OVYVO2&U1O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,37,1990 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 925 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes

REFERENCE :: ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,37,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2227 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 60,1810,1971

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 44 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report. Volume(issue)/page/year: 30101,11,1945

乙氧甲叉安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R42/43

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S27-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
OO1100000

[ 海关编码 ]:
2918990090

乙氧甲叉合成路线

乙氧甲叉上下游产品

乙氧甲叉上游产品

乙氧甲叉下游产品

乙氧甲叉制备

将原甲酸三乙酯、醋酐、丙二酸二乙酯和无水氧化锌的混合物搅拌加热，在102-115℃保温2.5h，在115-127℃保温7h，再补加部分醋酐和原甲酸三乙酯，继续升温至127-145℃保温2h，145-155℃保温2h。然后将反应物冷至室温，过滤。滤液减压蒸馏，收集108-110℃（33Pa）馏分，得成品，收率50-60%。

乙氧甲叉海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

乙氧甲叉文献

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For patients with celiac disease, gliadin detoxification via the use of gliadinases may provide an alternative to a gluten-free diet. A culture medium, in which gliadins were the sole source of nitrog...

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Impact of gluconic fermentation of strawberry using acetic acid bacteria on amino acids and biogenic amines profile.

Food Chem. 178 , 221-8, (2015)

This paper studies the amino acid profile of beverages obtained through the fermentation of strawberry purée by a surface culture using three strains belonging to different acetic acid bacteria specie...

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