粘氯酸

粘氯酸用途

【用途一】
是合成农药的主要原料，也是医药磺胺嘧啶类药的中间体
【用途二】
糠氯酸又名二氯代丁烯醛酸、粘氯酸，在农药上用于合成杀螨剂哒螨灵的中间体，也可用作有机合成中间体，用于合成磺胺嘧啶等药物。
【用途三】
有机合成中间体。用于合成广谱高效新型杀螨剂哒螨酮，除草剂苯纳松，也用于医药磺胺吡啶等和感光材料的合成。

粘氯酸名称

[ CAS 号 ]:
87-56-9

[ 中文名 ]:
粘氯酸

[ 英文名 ]:
3,4-Dichloro-5-hydroxy-2(5H)-furanone

[中文别名 ]:

[英文别名 ]:

3,4-dichloro-5-hydroxy-5H-furan-2-one
Dichloromalealdehydicaicd
EINECS 201-752-4
(2Z)-2,3-dichloro-4-oxobut-2-enoic acid
2-Butenoic acid, 2,3-dichloro-4-oxo-, (2Z)-
2,3-dichloro-4-oxo-cis-crotonic acid
2(5H)-Furanone, 3,4-dichloro-5-hydroxy-
(2Z)-2,3-Dichloro-4-oxo-2-butenoic acid
Mucochlorsure
MUCOCHLORICAICD

粘氯酸物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
271.0±40.0 °C at 760 mmHg

[ 熔点 ]:
125-128 °C(lit.)

[ 分子式 ]:
C₄H₂Cl₂O₃

[ 分子量 ]:
168.963

[ 闪点 ]:
117.7±27.3 °C

[ 精确质量 ]:
167.938095

[ PSA ]:
54.37000

[ LogP ]:
0.19

[ 外观性状 ]:
淡黄色液体

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.532

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、碱类分开存放

[ 水溶解性 ]:
SOLUBLE IN HOT WATER

粘氯酸MSDS

详细MSDS(安全技术说明书)

粘氯酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AS7700000

CHEMICAL NAME :: Acrylic acid, 2,3-dichloro-3-formyl-

CAS REGISTRY NUMBER :: 87-56-9

BEILSTEIN REFERENCE NO. :: 1705641

LAST UPDATED :: 199710

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C4-H2-Cl2-O3

MOLECULAR WEIGHT :: 168.96

WISWESSER LINE NOTATION :: VHYGUYGVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1218 mg/kg/9W-I

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - catalases Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6100 mg/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors Blood - tumors

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 23700 nmol/L

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 25,284,1995 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 0.1 mg/m3;Skin JAN 1993

粘氯酸安全信息

[ 符号 ]:

GHS05, GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H314-H317

[ 警示性声明 ]:
P280-P301 + P310-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P2 (EN 143) respirator cartridges;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;C:Corrosive;

[ 风险声明 (欧洲) ]:
R25;R34;R37;R42/43

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45-S22

[ 危险品运输编码 ]:
UN 2923 8/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
AS7700000

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
29183000

粘氯酸合成路线

详细合成路线

粘氯酸上下游产品

粘氯酸上游产品

粘氯酸下游产品

粘氯酸制备

【方法一】
糠氯酸是由糠醛和氯气为原料制备的。
在由三个柱子串联而成的串级式反应器内，于90～100℃下，用氯气连续氯化糠醛和浓盐酸(摩尔比1∶3)所构成的混合液。向第一个柱内以142g/h的速度供给糠醛，与分离了糠氯酸后的废液相混合，在此经氯气处理后再进入第二个柱内，与以1276g/h速度进料的糠醛相混合。再使反应混合液流至第三个柱内，同时以5250g/h的速度将氯气自柱子的底部通入，未反应的氯气再返回至第一个柱内。反应混合液在第一、第二、第三个柱内的滞留时间分别为20min、20min、30min，氯气与糠醛的摩尔比为5∶1。将氯化产物冷却至0～5℃，即可以2190g/h的速度获得糠氯酸，m.p.125～127℃，合成收率为87%。
【方法二】
1.糠醛氧化氯化法糠醛在强酸性溶液中通入氯气进行氧化和氯化而得。2.二氧化锰-盐酸氧化氯化法在盐酸存在下，糠醛与二氧化锰在低温下进行氧化，然后再升高温度进行氯化而得。

粘氯酸海关

[ 海关编码 ]: 29183000

粘氯酸文献

The toxicity of the mutagen 'MX' and its analogue, mucochloric acid, to rainbow trout hepatocytes and gill epithelial cells and to Daphnia magna.

Toxicology 100(1-3) , 69-77, (1995)

The cytotoxicity of the, in Salmonella, potent mutagenic compound, 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) and its structural analogue 3,4-dichloro-5-hydroxy-2[5H]-furanone (mucochlo...

Test of chiral recognition in the Salmonella typhimurium (TA100) mutagenicity of mucochloric acid-cysteine adducts.

Environ. Mol. Mutagen. 22(3) , 181-7, (1993)

A difference in biological response to enantiomers is not an uncommon observation and is, therefore, to be expected in various manifestations of genotoxicity. The bacterial mutagen mucochloric acid (2...

Effect of beta-cyclodextrin on mucochloric acid and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone.

Arch. Environ. Contam. Toxicol. 20(3) , 371-4, (1991)

Cyclodextrins form inclusion complexes with a wide range of guest molecules which wholly, or in part, fit into their hydrophobic cavity. Since no covalent bonds are formed in this complexation, the gu...

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粘氯酸