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四氯氢醌

四氯氢醌用途

Tetrachlorohydroquinone (TCHQ) 是 pentachlorophenol 的代谢产物。Tetrachlorohydroquinone 增加啮齿动物 DNA 损伤并诱导氧化应激。

四氯氢醌名称

[ CAS 号 ]:
87-87-6

[ 中文名 ]:
四氯氰醌

[ 英文名 ]:
Tetrachlorohydroquinone

[中文别名 ]:

[英文别名 ]:

Tetrachlorohydroquinone
EINECS 201-779-1
MFCD00041748
2,3,5,6-tetrachlorobenzene-1,4-diol

四氯氢醌生物活性

[ 描述 ]:

Tetrachlorohydroquinone (TCHQ) 是 pentachlorophenol 的代谢产物。Tetrachlorohydroquinone 增加啮齿动物 DNA 损伤并诱导氧化应激。

[ 相关类别 ]:

研究领域 >> 其他

[参考文献]

[1]. Pietsch C, et al. Cytotoxic effects of pentachlorophenol (PCP) and its metabolite tetrachlorohydroquinone (TCHQ) on liver cells are modulated by antioxidants. Cell Biol Toxicol. 2014 Aug;30(4):233-52.

四氯氢醌物理化学性质

[ 密度 ]:
1.848 g/cm3

[ 沸点 ]:
286.2ºC

[ 熔点 ]:
238-240 °C

[ 分子式 ]:
C₆H₂Cl₄O₂

[ 分子量 ]:
247.89

[ 闪点 ]:
126.9ºC

[ 精确质量 ]:
245.88100

[ PSA ]:
40.46000

[ LogP ]:
3.71140

[ 外观性状 ]:
黄褐色或淡黄色粉末

[ 折射率 ]:
1.661

[ 储存条件 ]:
室温

四氯氢醌MSDS

四氯氢醌毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MX7700000

CHEMICAL NAME :: Hydroquinone, tetrachloro-

CAS REGISTRY NUMBER :: 87-87-6

BEILSTEIN REFERENCE NO. :: 1876374

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H2-Cl4-O2

MOLECULAR WEIGHT :: 247.88

WISWESSER LINE NOTATION :: QR BG CG EG FG DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3319 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 368 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - muscle weakness

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Mammal - species unspecified Lymphocyte

DOSE/DURATION :: 50 mmol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 145,71,1985

四氯氢醌安全信息

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
22-41

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S39

[ RTECS号 ]:
MX7700000

[ 海关编码 ]:
2908199090

四氯氢醌合成路线

四氯氢醌上下游产品

四氯氢醌上游产品

四氯氢醌下游产品

四氯氢醌海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%