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N,N-二乙基氯甲酰胺

N,N-二乙基氯甲酰胺用途

【用途一】
用作医药及农药杀草丹的中间体
【用途二】
该品为医药、农药中间体，用于抗血丝虫药海群生、除草剂杀草丹等的生产。

N,N-二乙基氯甲酰胺名称

[ CAS 号 ]:
88-10-8

[ 中文名 ]:
N,N-二乙基氯甲酰胺

[ 英文名 ]:
Diethylcarbamic chloride

[中文别名 ]:

[英文别名 ]:

Carbamicchloride,diethyl
EINECS 201-798-5
MFCD00000636
diethylchloroformamide
N,N-diethylcarbamyl chloride
N,N-Diethylchloroformamide
Diethylcarbamyl chlo
diethylaminocarbonyl chloride
diethyl-carbamoylchlorid
N,N-diethylcarbamic acid chloride

N,N-二乙基氯甲酰胺物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
186.0±9.0 °C at 760 mmHg

[ 熔点 ]:
−32 °C(lit.)

[ 分子式 ]:
C₅H₁₀ClNO

[ 分子量 ]:
135.592

[ 闪点 ]:
75.0±0.0 °C

[ 精确质量 ]:
135.045090

[ PSA ]:
20.31000

[ LogP ]:
1.30

[ 外观性状 ]:
透明至略淡灰色液体

[ 蒸汽压 ]:
0.7±0.4 mmHg at 25°C

[ 折射率 ]:
1.446

[ 储存条件 ]:
存放于惰性气体之中;避免湿气 (分解)

[ 水溶解性 ]:
HYDROLYSIS

N,N-二乙基氯甲酰胺MSDS

详细MSDS(安全技术说明书)

N,N-二乙基氯甲酰胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD4025000

CHEMICAL NAME :: Carbamoyl chloride, diethyl-

CAS REGISTRY NUMBER :: 88-10-8

BEILSTEIN REFERENCE NO. :: 0506687

LAST UPDATED :: 199710

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C5-H10-Cl-N-O

MOLECULAR WEIGHT :: 135.61

WISWESSER LINE NOTATION :: GVN2&2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571246 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2700 mg/kg

TOXIC EFFECTS :: Behavioral - coma Gastrointestinal - alteration in gastric secretion Blood - changes in spleen

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571246

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 159 ppm/7H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571246

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 12840 mg/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571246 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5400 mg/kg/10D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Related to Chronic Data - death

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0571246 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 43200 mg/kg/72W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application

REFERENCE :: JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 6(4),479,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY;Carcinogen JAN 1993

N,N-二乙基氯甲酰胺安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H332-H335-H351

[ 警示性声明 ]:
P261-P281-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/22;R36/37/38;R40

[ 安全声明 (欧洲) ]:
S26-S36/37

[ 危险品运输编码 ]:
UN 3265 8/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
FD4025000

[ 包装等级 ]:
II

[ 危险类别 ]:
8

[ 海关编码 ]:
2903199000

N,N-二乙基氯甲酰胺合成路线

详细合成路线

N,N-二乙基氯甲酰胺上下游产品

N,N-二乙基氯甲酰胺上游产品

N,N-二乙基氯甲酰胺下游产品

N,N-二乙基氯甲酰胺制备

以乙二胺为原料，与光气进行甲酰氯化反应，制得粗品二乙胺基甲酰氯，经脱酸而得成品。

N,N-二乙基氯甲酰胺海关

[ 海关编码 ]: 2903199000

[ 中文概述 ]:
2903199000 其他无环烃的饱和氯化衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2903199000 other saturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

N,N-二乙基氯甲酰胺文献

[Determination of low levels of diethylcarbamoyl chloride in air. First results after inhalation in rat (author's transl)].

Toxicol. Eur. Res. 3(5) , 223-8, (1981)

更多文献