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15-O-乙酰脱氧瓜萎镰菌醇

15-O-乙酰脱氧瓜萎镰菌醇用途

15-Acetyl-deoxynivalenol 是一种在谷物中发现的剧毒单端孢霉烯,对 HepG2 细胞具有毒性。

15-O-乙酰脱氧瓜萎镰菌醇名称

[ CAS 号 ]:
88337-96-6

[ 中文名 ]:
15-O-乙酰脱氧瓜萎镰菌醇

[ 英文名 ]:
15-Acetyl-deoxynivalenol

[中文别名 ]:

15-乙酰脱氧瓜萎镰菌醇

[英文别名 ]:

15-ADON
15-ACETYLDEOXYNIVALENOL
Deoxynivalenol 15-Acetate
15-O-acetyl-4-deoxynivalenol
15-ACETYLVOMITOXIN
15-acetyl
15-Acetyl-4-deoxynivalenol
3-ACETYL-D3-DEOXYNIVALENOL
15-ACDON
DON-15-acetate

15-O-乙酰脱氧瓜萎镰菌醇生物活性

[ 描述 ]:

15-Acetyl-deoxynivalenol 是一种在谷物中发现的剧毒单端孢霉烯,对 HepG2 细胞具有毒性。

[ 相关类别 ]:

研究领域 >> 癌症

[参考文献]

[1]. Juan-García A, et al. Binary and tertiary combination of alternariol, 3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on HepG2 cells: Toxic effects and evaluation of degradation products. Toxicol In Vitro. 2016 Aug;34:264-273.

15-O-乙酰脱氧瓜萎镰菌醇物理化学性质

[ 密度 ]:
1.42g/cm3

[ 沸点 ]:
518.8ºC at 760 mmHg

[ 熔点 ]:
185°C-187°C

[ 分子式 ]:
C₁₇H₂₂O₇

[ 分子量 ]:
338.35200

[ 闪点 ]:
2ºC

[ 精确质量 ]:
338.13700

[ PSA ]:
105.59000

[ 折射率 ]:
1.595

[ 储存条件 ]:
2-8°C

15-O-乙酰脱氧瓜萎镰菌醇MSDS

15-O-乙酰脱氧瓜萎镰菌醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD0155000

CHEMICAL NAME :: Trichothec-9-en-8-one, 15-(acetyloxy)-12,13-epoxy-3,7-dihydroxy-, (3-alpha,7-alpha)-

CAS REGISTRY NUMBER :: 88337-96-6

LAST UPDATED :: 198708

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C17-H22-O7

MOLECULAR WEIGHT :: 338.39

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 34 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder Blood - changes in spleen

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 25,155,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEMIDF Applied and Environmental Microbiology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.31- 1976- Volume(issue)/page/year: 50,1304,1985

15-O-乙酰脱氧瓜萎镰菌醇安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H300-H311-H331

[ 警示性声明 ]:
P261-P264-P280-P301 + P310-P311

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T,Xn,F

[ 风险声明 (欧洲) ]:
23/24/25-36-20/21/22-11

[ 安全声明 (欧洲) ]:
36/37-45-26

[ 危险品运输编码 ]:
UN 2811 6.1/PG 2

[ WGK德国 ]:
3

[ RTECS号 ]:
YD0155000

[ 包装等级 ]:
I

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
29329990

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15-O-乙酰脱氧瓜萎镰菌醇文献

Development and validation of a high performance liquid chromatographic-mass spectrometry method for the simultaneous quantification of 10 trichothecenes in ultra-high temperature processed cow milk.

J. Chromatogr. A. 1419 , 37-44, (2015)

An LC-MS/MS (QqQ) method has been developed and validated for simultaneous determination of the following trichothecenes in UHT cow milk: nivalenol (NIV), deoxynivalenol (DON), deepoxy-deoxynivalenol ...

Innate Immune Sensing of Fusarium culmorum by Mouse Dendritic Cells.

J. Toxicol. Environ. Health A 78 , 871-85, (2015)

Chronic inhalation of grain dust is associated with asthma and chronic bronchitis in grain worker populations. Exposure to fungal particles was postulated to be an important etiologic agent of these p...

Determination of the Mycotoxin Content in Distiller's Dried Grain with Solubles Using a Multianalyte UHPLC-MS/MS Method.

J. Agric. Food Chem. 63 , 9441-51, (2015)

There are more than 300 potential mycotoxins that can contaminate food and feed and cause adverse effects in humans and animals. The data on the co-occurrence of mycotoxins in novel animal feed materi...

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