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聚丙烯酸

聚丙烯酸用途

聚丙烯酸是一种分子量为2000的聚丙烯酸。

聚丙烯酸名称

[ CAS 号 ]:
9003-01-4

[ 中文名 ]:
聚丙烯酸

[ 英文名 ]:
Polyacrylic acid

[中文别名 ]:

[英文别名 ]:

PAA
Poly(acrylic acid)
Propenoic acid polymer
EINECS 618-347-7
Acrylic acid polymer
MFCD00084394
2-Propenoic acid homopolymer
Carbomer 940
Polyacrylic acid
Carbomer 934

聚丙烯酸生物活性

[ 描述 ]:

聚丙烯酸是一种分子量为2000的聚丙烯酸。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

聚丙烯酸物理化学性质

[ 密度 ]:
1.09 (30% aq.)

[ 沸点 ]:
116ºC

[ 熔点 ]:
106ºC

[ 分子式 ]:
(C₃H₄O₂)x

[ 分子量 ]:
2000(Average)

[ 闪点 ]:
61.6ºC

[ 精确质量 ]:
72.02110

[ PSA ]:
37.30000

[ LogP ]:
0.25700

[ 外观性状 ]:
无色粘性液体

[ 折射率 ]:
n20/D 1.442

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
Soluble in water.

聚丙烯酸MSDS

详细MSDS(安全技术说明书)

聚丙烯酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AT4680000

CHEMICAL NAME :: Acrylic acid, polymers

CAS REGISTRY NUMBER :: 9003-01-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: (C3-H4-O2)x

MOLECULAR WEIGHT :: 168.06

WISWESSER LINE NOTATION :: /*1Y*VQ/

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPPAO Farmaco, Edizione Pratica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 25,721,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 39 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 21,652,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZMEIAV Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii. Journal of Microbiology, Epidemiology, and Immunology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.14- 1935- Volume(issue)/page/year: (9),14,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 114,258,1958 *** REVIEWS *** IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,47,1979 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,47,1979 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82129 No. of Facilities: 2084 (estimated) No. of Industries: 44 No. of Occupations: 55 No. of Employees: 34007 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7610 No. of Facilities: 31268 (estimated) No. of Industries: 198 No. of Occupations: 162 No. of Employees: 571954 (estimated) No. of Female Employees: 232712 (estimated)

聚丙烯酸安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H340-H350

[ 警示性声明 ]:
P201-P308 + P313

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
C: Corrosive;T: Toxic;Xi: Irritant;

[ 风险声明 (欧洲) ]:
45-46-34-36/37/38

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
UN 3265 8/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
AT4680000

[ 海关编码 ]:
3906909090

聚丙烯酸制备

以丙烯酸为单体在引发剂存在下进行聚合而得。
丙烯酸的制法

a.氰乙醇法以氯乙醇为原料，与氰化钠瓜得氰乙醇。氰乙醇在硫酸存在的情况下于175℃水解得丙烯酸。

b.丙烯腈水解法以丙烯腈为原料在硫酸存在下水解生成丙烯酰胺的硫酸盐，再水解得到丙烯酸。

c.雷佩法与改良雷佩法将乙炔溶于四氢呋喃中，计量后加入反应釜。在溴化镍和溴化铜组成的催化剂存在下通一氧化碳和水，在200～225℃下，7.8～9.8 MPa反应。

d.丙烯醛氧化法将丙烯，空气，水按1︰10︰6 （V）的比例进行混合，然后通入第一沸腾床，在铝、钒、磷、铁、铝、镍、钾的催化下于370～390℃停留5.5s，线速度0.6m/s。然后进入第二沸腾床，在铝－钒＝钨催化下，停留2.25s，反应温度控制在270～300℃。丙烯酸的空时收率为55～60 kg/m·h，这种方法安全，污染轻，成本低，是国内外生产的主要方法。

聚丙烯酸的制备将去离子水加入聚合釜中，加热60～100℃，开始滴加过硫酸铵和丙烯酸的混合溶液（用去离子水配置）。滴毕后，继续保温搅拌3～4h。即得产品。将530kg去离子水加入聚合釜中，加入41kg平平加OS-15搅拌溶解。再加入4kg十二烷基硫酸钠，搅拌溶解后在20min内加入68kg混合单体（丙烯酸丁酯，丙烯腈）。搅拌15mi后加入1.5%的过硫酸铵水溶液30kg，30min内加完。继续搅拌15min后缓慢升温至70℃，开始滴加混合单体（272kg），大约1h滴完。加完后在80℃保温搅拌1h。
反应完毕后降温至40℃左右，加入70kg平平加OS-15，搅拌15min后过滤，除去杂质得产品

e.采用溶液聚合方法，以丙烯酸为原料，经水稀释后，在引发剂作用下聚合而成。丙烯酸聚合既快又放热，为实现对聚合过程的控制，用于循环水处理的聚丙烯酸制取中，通常把丙烯酸配成40%以下的水溶液进行聚合，聚合温度通常控制在50～150℃。常用引发剂为过硫酸铵和亚硫酸钠，在聚合过程中还常
加少量的（＜5%）巯基琥珀酸、异丙醇等做缓聚剂，对苯二酚或邻苯二酚用作阻聚剂。将一定化学计量的去离子水加入到装有电动搅拌器、回流冷凝管、滴液漏斗和温度计的反应器中，开动搅拌并将反应温度升至80℃左右、将计量的巯基乙酸或异丙醇加入到反应器中与水混溶。将化学计量的过硫酸铵用计量的水配成稀溶液，置于聚合反应器上的滴液漏斗中，将计量的丙烯酸（AA）单体与一定量水混合，置于聚合反应器上的另一滴液漏斗中。当反应器中的水温达到反应所需要的温度后，开始滴加丙烯酸单体水溶液和引发剂过硫酸铵水溶液，控制滴加速度使反应温度在85～90℃之间，聚合反应3～5H。反应完成后，将聚合液冷却至室温，取样分析各项技术指标，符合要求后分装。

聚丙烯酸海关

[ 海关编码 ]: 3906909090

聚丙烯酸文献

Cyclodextrin-crosslinked poly(acrylic acid): adhesion and controlled release of diflunisal and fluconazole from solid dosage forms.

AAPS PharmSciTech 14(1) , 301-11, (2013)

The controlled release of diflunisal and fluconazole from tablets made of novel polymers, poly(acrylic acid) (PAA) crosslinked with either β-cyclodextrin (βCD) or hydroxypropyl-βCD (HPβCD), was invest...

Cyclodextrin-crosslinked poly(acrylic acid): Synthesis, physicochemical characterization and controlled release of diflunisal and fluconazole from hydrogels.

Int. J. Pharm. 444(1-2) , 175-84, (2013)

The aim of this work was to develop mucoadhesive hydrogels with variable drug delivery properties by crosslinking poly(acrylic acid) (PAA) with cyclodextrins (CDs). CD-PAA polymers with high CD conten...

Chest wall reconstruction using biomaterials.

Ann. Thorac. Surg. 95(3) , 1050-6, (2013)

Skeletal chest wall reconstruction can be a challenge, depending on the indication, location, and health of the patient; various materials are available. Recently, biomaterials that are remodelable (b...

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