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聚乙烯吡咯烷酮

聚乙烯吡咯烷酮用途

Polyvinylpyrrolidone 当与碘和其他化合物结合时,广泛地在人类和兽医学中被用作有效的伤口愈合促进剂和消毒剂。

聚乙烯吡咯烷酮名称

[ CAS 号 ]:
9003-39-8

[ 中文名 ]:
聚乙烯吡咯烷酮

[ 英文名 ]:
Polyvinylpyrrolidone

[中文别名 ]:

[英文别名 ]:

k60
Polyvinylpyrrolidone
PVP
Kollidon K25
Kollidon K-90
k25
MFCD00149016
POP
Kollidon 25
k115

聚乙烯吡咯烷酮生物活性

[ 描述 ]:

Polyvinylpyrrolidone 当与碘和其他化合物结合时,广泛地在人类和兽医学中被用作有效的伤口愈合促进剂和消毒剂。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 感染

生化试剂

[体内研究]

用盐处理的金鱼在25小时时具有显着较低的粘液重量。用聚乙烯吡咯烷酮(PVP)处理的金鱼在25小时时具有显着更高的粘液重量。用盐和聚乙烯吡咯烷酮(PVP)处理的锦鲤在1小时和25小时具有显着更低的粘液重量。对照锦鲤在25小时时具有显着更高的粘液。在2周结束时,确定用盐和聚乙烯吡咯烷酮(PVP)处理的三种锦鲤保持健康并且显示出比其他治疗锦鲤和对照组更高的愈合程度[1]。

[动物实验]

罐内的每条鱼都可以作为复制品。处理指定为聚乙烯吡咯烷酮（剂量为10mL / 10加仑）和盐水/盐，浓度为3g / L.研究中还包括未接受任何化学物质的对照组。来自每个处理组的所有鱼在0分钟，15分钟，1小时，4小时和25小时取样。在每个时间间隔，使用缓冲的三卡因甲磺酸盐对来自每个处理组的所有鱼进行麻醉，称重，并且使用预先称重的塑料盖玻片从在epaxial肌肉组织上的1cm 2区域刮下粘液[1]。

[参考文献]

[1]. Shivappa RB, et al. Laboratory evaluation of different formulations of Stress Coat? for slime production in goldfish (Carassius auratus) and koi (Cyprinus carpio). PeerJ. 2017 Sep 6;5:e3759.

[相关活性小分子]

聚乙烯吡咯烷酮物理化学性质

[ 密度 ]:
1.144g/cm3

[ 沸点 ]:
217.6ºC at 760 mmHg

[ 熔点 ]:
130ºC

[ 分子式 ]:
(C₆H₉NO)n

[ 分子量 ]:
111.1418 (monomer)

[ 闪点 ]:
93.9ºC

[ PSA ]:
20.31000

[ LogP ]:
0.69020

[ 外观性状 ]:
白色粉末

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
H2O: soluble100mg/mL

聚乙烯吡咯烷酮MSDS

详细MSDS(安全技术说明书)

聚乙烯吡咯烷酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TR8300000

CHEMICAL NAME :: Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.5

CAS REGISTRY NUMBER :: 9003-39-8

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

WISWESSER LINE NOTATION :: /T5NVTJ AY*1*/

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - tumors

REFERENCE :: AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Reproductive - Tumorigenic effects - uterine tumors

REFERENCE :: AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8000 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Cardiac - tumors Endocrine - tumors

REFERENCE :: AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS. Volume(issue)/page/year: 67,589,1959 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 19,461,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81235 No. of Facilities: 7856 (estimated) No. of Industries: 50 No. of Occupations: 63 No. of Employees: 102100 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7211 No. of Facilities: 7688 (estimated) No. of Industries: 46 No. of Occupations: 63 No. of Employees: 161259 (estimated) No. of Female Employees: 84819 (estimated)

聚乙烯吡咯烷酮安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
TR8370000

[ 海关编码 ]:
3905990000

聚乙烯吡咯烷酮合成路线

详细合成路线

聚乙烯吡咯烷酮上下游产品

聚乙烯吡咯烷酮上游产品

聚乙烯吡咯烷酮下游产品

聚乙烯吡咯烷酮制备

1.由N-乙烯基-2-吡咯烷酮在碱性催化剂或N，N’-二乙烯咪唑存在下进行聚合、交联反应而成粗品，再用水、5%醋酸和50%乙醇回流至萃出物≤50mg/kg为止(约3h以上)。由纯化的1-乙烯-2-吡咯烷酮的30%～60%水溶液，在氨或胺等存在下，以过氧化氢为催化剂，在50℃温度下进行交链均聚后提纯而得。由N-乙烯基-2-吡咯烷酮在碱性催化剂或N，N’-二乙烯脒存在下进行聚合、交联得粗品，再用水、5％醋酸和50％乙醇回流至萃取物≤50mg/kg为止。

2.由N-乙烯基-2-吡咯烷酮在碱性催化剂或N,N'-二乙烯咪唑存在下进行聚合，再经精制而得。

3.由环己胺和氨基磺酸钠反应，经结晶、精制制得。或者由环己胺和三氧化硫反应制得。还可由环己胺和氯磺酸反应制得。

4.乙炔法工艺路线（Reppe该法以乙炔为主要的起始原料，故称乙炔法，是发展至今最为成熟的合成及生产犖乙烯基吡咯烷酮（NVP法。

以载于硅胶上的乙炔亚酮为催化剂，在0.50Pa，乙炔和甲醛反应首先制得丁炔二醇。再以骨架镍为催化剂，在乙醇中加氢，可生成1,4-丁二醇。

1,4- 丁二醇在200℃过铜催化剂进行气相脱氢生产γ-内酯，γ-内酯在一定压力下与氨反应，生成吡咯烷酮。

吡咯烷酮在1.01～2.03kPa115～125℃、碱催化剂存在下，与乙炔反应生成乙烯基吡咯烷酮

N-乙烯基吡咯烷酮按不同用途，可采用本体聚合、溶液聚合或悬浮聚合等聚合方式生产不同分子量的PVP。聚合产物经分离、干燥PVP产品。

聚乙烯吡咯烷酮海关

[ 海关编码 ]: 3905990000

聚乙烯吡咯烷酮文献

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