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脱氧核糖核酸酶

脱氧核糖核酸酶用途

脱氧核糖核酸酶(DNase)是一种降解DNA的酶,它在细胞外DNA的裂解中起着关键作用,对限制炎症反应和维持体内稳定至关重要。外源性脱氧核糖核酸酶在炎症性疾病和癌症中显示出有益的作用[1]。

脱氧核糖核酸酶名称

[ CAS 号 ]:
9003-98-9

[ 中文名 ]:
脱氧核糖核酸酶

[ 英文名 ]:
Deoxyribonuclease

[中文别名 ]:

去氧核糖核酸酶

[英文别名 ]:

Alkaline DNase
Alkaline deoxyribonuclease
DNA depolymerase
DNA endonuclease
DNA nuclease
DNAase
DNase
Deoxyribonuclease A
Deoxyribonuclease I
Deoxyribonucleic phosphatase

脱氧核糖核酸酶生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体内研究]

脱氧核糖核酸酶(0.1U；i.p.；每天一次,持续3天)抑制肝转移,此外,通过联合手术切除原发性肿瘤块,可延长生存期[1]。动物模型：雌性BALB/c x DBA/2小鼠皮下注射小鼠肿瘤L5178Y-ML细胞[1]剂量：每只小鼠0.1 U给药：静脉注射；0.1 U；结果：肝脏重量从2.26克减少到1.55克,影响肝转移强度,减少转移的数量和大小,并影响肿瘤细胞停滞。动物模型：雌性BALB/c x DBA/2小鼠,患有小鼠肿瘤并手术切除皮下肿瘤[1]剂量：每只小鼠0.1 U给药：静脉注射；0.1 U；结果：与未治疗组相比,肿瘤细胞接种后的存活率显著延长。

脱氧核糖核酸酶物理化学性质

[ 密度 ]:
100 g/mL at 20 °C

[ 外观性状 ]:
solution (clear, colorless) | white

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble in 0.15 M sodium chloride (5.0mg/L) clear.

脱氧核糖核酸酶安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 安全声明 (欧洲) ]:
23-24/25-22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
RF0750000

脱氧核糖核酸酶制备

1.以牛胰为原料，经稀硫酸抽提后由硫酸铵和乙醇分级沉淀得产品.

脱氧核糖核酸酶文献

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Cell Death Differ. 22 , 1970-84, (2015)

Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinuclea...

ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation.

Autophagy 11 , 1308-25, (2015)

Recent studies have shown that the phosphorylation and dephosphorylation of ULK1 and ATG13 are related to autophagy activity. Although ATG16L1 is absolutely required for autophagy induction by affecti...

Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.

Autophagy 11(1) , 166-82, (2015)

The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated thro...

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