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海藻酸钙

海藻酸钙用途

海藻酸钙是一种生物聚合物,可用于开发口服给药系统[1]。海藻酸钙是一种pH敏感水凝胶,在酸性介质中稳定,在碱性介质中可溶[2]。

海藻酸钙名称

[ CAS 号 ]:
9005-35-0

[ 中文名 ]:
海藻酸钙

[ 英文名 ]:
Calcium alginate

[中文别名 ]:

藻酸钙

[英文别名 ]:

MFCD00143567

海藻酸钙生物活性

[ 描述 ]:

海藻酸钙是一种生物聚合物,可用于开发口服给药系统[1]。海藻酸钙是一种pH敏感水凝胶,在酸性介质中稳定,在碱性介质中可溶[2]。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体外研究]

海藻酸钙是一种pH敏感水凝胶,在酸性介质中稳定,在碱性介质中可溶。这使水凝胶能够在一定的pH值范围内吸收和释放水溶液。通过吸收含有药物的水溶液,可以在指定的pH值范围内触发活性药物释放[2]。海藻酸钙是一种可生物降解的凝胶转化剂,广泛用于鼻腔填塞。它可以减轻疼痛,提高舒适度[3]。

[参考文献]

[1]. Demitri C, et al. Encapsulation of Lactobacillus kefiri in alginate microbeads using a double novel aerosol technique. Mater Sci Eng C Mater Biol Appl. 2017;77:548-555.

[2]. Chengzhi Hu, et al. Electrosynthesis of magnetoresponsive microrobot for targeted drug delivery using calcium alginate. Annu Int Conf IEEE Eng Med Biol Soc. 2016;2016:2111-2114.

[3]. Park DY, et al. Comparison of calcium alginate and carboxymethyl cellulose for nasal packing after endoscopic sinus surgery: a prospective, randomised, controlled single-blinded trial. Clin Otolaryngol. 2016;41(3):234-240.

海藻酸钙物理化学性质

[ 密度 ]:
2.1173 g/cm3

[ 分子式 ]:
C₃₆H₄₂Ca₃O₃₆

[ 分子量 ]:
1170.93000

[ 精确质量 ]:
1170.03000

[ PSA ]:
511.32000

[ 外观性状 ]:
凝胶状的,奶油色物质

[ 储存条件 ]:
库房低温通风干燥

海藻酸钙MSDS

详细MSDS(安全技术说明书)

海藻酸钙毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AZ5810000

CHEMICAL NAME :: Alginic acid, calcium salt

CAS REGISTRY NUMBER :: 9005-35-0

LAST UPDATED :: 199701

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1407 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,381,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 64 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. Volume(issue)/page/year: 53A,381,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83092 No. of Facilities: 47 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 94 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83092 No. of Facilities: 643 (estimated) No. of Industries: 16 No. of Occupations: 7 No. of Employees: 3968 (estimated)

海藻酸钙安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
AZ5820000

海藻酸钙制备

由海藻酸与氢氧化钙或碳酸钙反应而得。

海藻酸钙文献

Safety and efficacy of ethylenediaminetetraacetic acid for removing microcapsules.

J. Surg. Res. 183(1) , 442-9, (2013)

Microencapsulated islets are used to prevent immune rejection associated with pancreatic islet transplantation, but cellular overgrowth affects transplantation success, necessitating removal of microc...

Optimization of sustained release matrix tablet of metoprolol succinate using central composite design.

Pak. J. Pharm. Sci. 26(5) , 929-37, (2013)

The present study was performed to optimize the formulation of metoprolol succinate (MS) sustained release tablets using hydroxypropyl methylcellulose (HPMC) and sodium alginate (SA) as the matrix com...

Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration.

Int. J. Pharm. 454(1) , 125-34, (2013)

The present study aimed to prepare a chemically and physically stable formulation of baicalein (Ba) in an in situ thermally sensitive hydrogel for vaginal administration. An inclusion complex of Ba an...

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