青霉素酰胺酶 来源于大肠杆菌

青霉素酰胺酶(青霉素酰化酶)是一种切割青霉素酰基侧链的酶。青霉素酰胺酶可用于生产6-氨基青霉烷酸。青霉素酰胺酶也可用于拆分外消旋混合物、肽合成和半合成β-内酰胺抗生素的合成[1][2][3]。

[ 描述 ]:

[ 相关类别 ]:

[参考文献]

[ 外观性状 ]:
lyophilized powder

[ 储存条件 ]:
2-8°C

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
42/43

[ 安全声明 (欧洲) ]:
22-36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

Structure of a class III engineered cephalosporin acylase: comparisons with class I acylase and implications for differences in substrate specificity and catalytic activity.

Biochem. J. 451(2) , 217-26, (2013)

The crystal structure of the wild-type form of glutaryl-7-ACA (7-aminocephalosporanic acid) acylase from Pseudomonas N176 and a double mutant of the protein (H57βS/H70βS) that displays enhanced cataly...

Enantioselective acylation of β-phenylalanine acid and its derivatives catalyzed by penicillin G acylase from Alcaligenes faecalis.

Prep Biochem Biotechnol. 43(2) , 207-16, (2013)

This study developed a simple, efficient method for producing racemic β-phenylalanine acid (BPA) and its derivatives via the enantioselective acylation catalyzed by the penicillin G acylase from Alcal...

Engineering the substrate specificity of a thermophilic penicillin acylase from thermus thermophilus.

Appl. Environ. Microbiol. 79(5) , 1555-62, (2013)

A homologue of the Escherichia coli penicillin acylase is encoded in the genomes of several thermophiles, including in different Thermus thermophilus strains. Although the natural substrate of this en...

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