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1,11-二氨基-3,6,9-三氧杂十一烷

1,11-二氨基-3,6,9-三氧杂十一烷用途

Amino-PEG3-C2-Amine 是一种 PROTAC 连接桥 (3 个单元),属于 PEG 类。Amino-PEG3-Amino 可用于合成一系列 PROTAC 分子。

1,11-二氨基-3,6,9-三氧杂十一烷名称

[ CAS 号 ]:
929-75-9

[ 中文名 ]:
3,6,9-三氧杂十一烷-1,11-二胺

[ 英文名 ]:
Amino-PEG3-C2-Amine

[中文别名 ]:

[英文别名 ]:

EINECS 213-206-2
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanamine
Ethanamine, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-
2,2'-[Oxybis(ethylenoxy)]diethylamine
2,2'-[Oxybis(2,1-ethanediyloxy)]diethanamine
MFCD00628164
3,6,9-trioxaundecamethylenediamine

1,11-二氨基-3,6,9-三氧杂十一烷生物活性

[ 描述 ]:

Amino-PEG3-C2-Amine 是一种 PROTAC 连接桥 (3 个单元),属于 PEG 类。Amino-PEG3-Amino 可用于合成一系列 PROTAC 分子。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[体外研究]

PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

[参考文献]

[1]. Lepage ML, et al. Design, synthesis and photochemical properties of the first examples of iminosugar clustersbased on fluorescent cores. Beilstein J Org Chem. 2015 May 6;11:659-67.

1,11-二氨基-3,6,9-三氧杂十一烷物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
291.1±25.0 °C at 760 mmHg

[ 分子式 ]:
C₈H₂₀N₂O₃

[ 分子量 ]:
192.256

[ 闪点 ]:
131.8±16.8 °C

[ 精确质量 ]:
192.147400

[ PSA ]:
79.73000

[ LogP ]:
-1.94

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.462

[ 储存条件 ]:
室温

1,11-二氨基-3,6,9-三氧杂十一烷MSDS

1,11-二氨基-3,6,9-三氧杂十一烷安全信息

[ 符号 ]:

GHS05, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H315-H318-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R37/38;R41

[ 安全声明 (欧洲) ]:
S26-S39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2922199090

1,11-二氨基-3,6,9-三氧杂十一烷合成路线

1,11-二氨基-3,6,9-三氧杂十一烷上下游产品

1,11-二氨基-3,6,9-三氧杂十一烷上游产品

1,11-二氨基-3,6,9-三氧杂十一烷下游产品

1,11-二氨基-3,6,9-三氧杂十一烷海关

[ 海关编码 ]: 2922199090

[ 中文概述 ]:
2922199090. 其他氨基醇及其醚，酯和它们的盐（但含一种以上含氧基的除外）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

1,11-二氨基-3,6,9-三氧杂十一烷文献

Orthogonal, convergent syntheses of dendrimers based on melamine with one or two unique surface sites for manipulation.

J. Am. Chem. Soc. 123 , 8914 - 8922 , (2001)

An orthogonal, convergent route for the introduction of substoichiometric numbers of latent surface sites into dendrimers based on melamine is used to prepare targets that display one or two Boc-prote...

Non-natural glycosphingolipids and structurally simpler analogues bind HIV-1 recombinant Gp120.

Bioorg. Med. Chem. 10 , 625- 637, (2002)

Interactions of recombinant gp120 (rgp120) with non-natural glycosphingolipids (GSLs) and structurally simpler analogues have been studied using a competitive adhesion assay. Conjugates of cellobiosyl...

Recapitulation of in vivo-like paracrine signals of human mesenchymal stem cells for functional neuronal differentiation of human neural stem cells in a 3D microfluidic system.

Biomaterials 63 , 177-88, (2015)

Paracrine signals produced from stem cells influence tissue regeneration by inducing the differentiation of endogenous stem or progenitor cells. However, many recent studies that have investigated par...

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