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2-甲基-4-氯苯氧乙酸

2-甲基-4-氯苯氧乙酸用途

MCPA 是一种苯氧基除草剂,广泛用于控制一年生和多年生阔叶杂草。

2-甲基-4-氯苯氧乙酸名称

[ CAS 号 ]:
94-74-6

[ 中文名 ]:
2甲4氯

[ 英文名 ]:
MCPA

[中文别名 ]:

[英文别名 ]:

Acetic acid, (4-chloro-2-methylphenoxy)-
2M-4Ch
MCPA
metaxon
Weed-rhap
Chiptox
Agroxon
Zelan
(4-Chloro-2-methylphenoxy)acetic acid
cornox

2-甲基-4-氯苯氧乙酸生物活性

[ 描述 ]:

MCPA 是一种苯氧基除草剂,广泛用于控制一年生和多年生阔叶杂草。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Munira S, et, al. Sorption and desorption of glyphosate, MCPA and tetracycline and their mixtures in soil as influenced by phosphate. J Environ Sci Health B. 2017 Dec 2;52(12):887-895.

[2]. Kwiecien I, et, al. Biodegradable PBAT/PLA Blend with Bioactive MCPA-PHBV Conjugate Suppresses Weed Growth. Biomacromolecules. 2018 Feb 12;19(2):511-520.

2-甲基-4-氯苯氧乙酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
327.0±27.0 °C at 760 mmHg

[ 熔点 ]:
114-118 °C(lit.)

[ 分子式 ]:
C₉H₉ClO₃

[ 分子量 ]:
200.619

[ 闪点 ]:
151.6±23.7 °C

[ 精确质量 ]:
200.024017

[ PSA ]:
46.53000

[ LogP ]:
2.49

[ 外观性状 ]:
白色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.552

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
水溶性：不溶；水溶解度：630 mg/l 25 °C；易溶于：乙醇；可溶于：甲醇,乙醚,苯,甲苯

2-甲基-4-氯苯氧乙酸MSDS

2-甲基-4-氯苯氧乙酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG1575000

CHEMICAL NAME :: Acetic acid, ((4-chloro-o-tolyl)oxy)-

CAS REGISTRY NUMBER :: 94-74-6

BEILSTEIN REFERENCE NO. :: 2051752

LAST UPDATED :: 199710

DATA ITEMS CITED :: 35

MOLECULAR FORMULA :: C9-H9-Cl-O3

MOLECULAR WEIGHT :: 200.63

WISWESSER LINE NOTATION :: QV1OR DG B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 814 mg/kg

TOXIC EFFECTS :: Behavioral - coma Vascular - BP lowering not characterized in autonomic section

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Gastrointestinal - gastritis Behavioral - somnolence (general depressed activity) Liver - fatty liver degeneration

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1370 mg/m3/4H

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 439 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 377 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14400 mg/kg/90D-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2129 mg/kg/78W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Blood - leukemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 3 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1 gm/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: DNA inhibition

MUTATION DATA

TEST SYSTEM :: Rodent - hamster

DOSE/DURATION :: 900 mg/kg/9D (Intermittent)

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,703,1984 *** REVIEWS *** IARC Cancer Review:Human Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,357,1986 IARC Cancer Review:Animal No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 30,255,1983 TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989

2-甲基-4-氯苯氧乙酸安全信息

[ 符号 ]:

GHS02, GHS07

[ 信号词 ]:
Danger

[ 危害声明 ]:
H225-H302-H312-H319-H332

[ 警示性声明 ]:
P210-P280-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R38;R41

[ 安全声明 (欧洲) ]:
S26-S37-S39-S36-S16

[ 危险品运输编码 ]:
UN 2765

[ WGK德国 ]:
2

[ RTECS号 ]:
AG1575000

[ 海关编码 ]:
2918990022

2-甲基-4-氯苯氧乙酸合成路线

2-甲基-4-氯苯氧乙酸上下游产品

2-甲基-4-氯苯氧乙酸上游产品

2-甲基-4-氯苯氧乙酸下游产品

2-甲基-4-氯苯氧乙酸制备

1、由邻甲酚经缩合、酸化、氯化而得。将26.24kg邻甲酚、13.9kg水、35%的氢氧化钠溶液27.37kg投入缩合锅内，在70℃以下搅拌配合成邻甲酚钠盐。在21.88kg氯乙酸和41.66kg水中，在25℃以下慢慢加入35%的氢氧化钠溶液26.56kg，使pH值为5-6，在60℃条件下酸化20min。将反应物在脱酚槽内加热至90-95℃，通过热蒸气脱酚。然后在pH值为1-2、60-65℃条件下氯化。再经冷却、过滤、水洗即得2-甲-4-氯。原药2-甲-4-氯钠原药为深褐色粉末，按HG 2-1460-82，有效成分含量≥56.0%。原料消耗定额：邻甲酚730kg/t、液氯600kg/t、氯乙酸740kg/t、液碱3000kg/t、盐酸（30%）180kg/t。

2、 2甲4氯的生产方法可概括为先缩合后氯化和先氯化后缩合2种。两种方法各有优缺点，先缩合后氯化生产原理如下。
缩合于100～105℃ 反应1h，缩合反应即完成。

酸化用盐酸调节pH值至5左右，于90～95℃进行脱酚处理。

氯化加盐酸调节pH值1～2，于60℃左右通氯氯化，到终点后冷却、过滤、水洗得2甲4氯。
成盐由于2甲4氯水溶性较小，直接用于农田除草困难，工业上多调配成钠盐、铵盐或酯类。

3.由邻甲酚、水、液碱反应制得邻甲酚钠。另将氯乙酸溶于水中，在常温下慢慢加入液碱，配成氯乙酸钠溶液。然后将配好的氯乙酸钠水溶液缓慢地加入到邻甲酚钠溶液中，进行缩合反应，处理后，加盐酸进行氯化，经冷却、过滤、水洗得２甲４氯。该品商品为2-甲-4-氯钠盐，加工成水剂。

2-甲基-4-氯苯氧乙酸海关

[ 海关编码 ]: 2918990022

[ 中文概述 ]:
2918990022. 2甲4氯、2甲4氯丙酸等〔包括精2甲4氯丙酸〕. 增值税率:17.0%. 退税率:9.0%. 监管条件:S(进出口农药登记证明). 最低关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2918990022 2-(4-chloro-2-methylphenoxy)acetic acid。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

2-甲基-4-氯苯氧乙酸文献

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Monetite granules versus particulate autologous bone in bone regeneration.

Ann. Anat. 200 , 126-33, (2015)

The aim of this study was to test bone tissue response to monetite granules in comparison with intramembranous autologous bone graft in a rabbit calvaria critical size defect model.Novel monetite gran...

The role of microbial adaptation and biodegradable dissolved organic carbon on the attenuation of trace organic chemicals during groundwater recharge.

Sci. Total Environ. 437 , 137-44, (2012)

It is widely recognized that efficient biological attenuation of bulk organic matter and trace organic chemicals (TOrC) can occur in managed aquifer recharge (MAR) systems receiving reclaimed water. T...

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