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AS-136A

AS-136A用途

AS-136A是麻疹病毒RNA依赖性RNA聚合酶(RdRp)的口服活性非核苷抑制剂,麻疹病毒的IC50为2µM【1】。

AS-136A名称

[ CAS 号 ]:
949898-66-2

[ 英文名 ]:
AS-136A

[英文别名 ]:

AS-136A

AS-136A生物活性

[ 描述 ]:

AS-136A是麻疹病毒RNA依赖性RNA聚合酶(RdRp)的口服活性非核苷抑制剂,麻疹病毒的IC50为2µM【1】。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成

[参考文献]

[1]. Ndungu JM, et al. Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics. J Med Chem. 2012;55(9):4220-4230.

AS-136A物理化学性质

[ 分子式 ]:
C₁₇H₁₉F₃N₄O₃S

[ 分子量 ]:
416.41800

[ 精确质量 ]:
416.11300

[ PSA ]:
92.68000

[ LogP ]:
3.95750

AS-136AMSDS

详细MSDS(安全技术说明书)

AS-136A安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 危险品运输编码 ]:
NONH for all modes of transport

AS-136A文献

Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase: synthesis, structure-activity relationships, and pharmacokinetics.

J. Med. Chem. 55(9) , 4220-30, (2012)

The measles virus (MeV), a member of the paramyxovirus family, is an important cause of pediatric morbidity and mortality worldwide. In an effort to provide therapeutic treatments for improved measles...

Target analysis of the experimental measles therapeutic AS-136A.

Antimicrob. Agents Chemother. , (2009)

No effective therapeutic is currently in place for improved case management of severe measles or the rapid control of outbreaks. Through high-throughput screening, we recently identified a novel small...

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