茚

茚用途

【用途一】
用于合成树脂、杀虫剂及用作溶剂
【用途二】
除少量用于有机溶剂和杀虫剂的中间体外，主要用于生产茚-古马隆树脂。茚-古马隆树脂的原料是重苯和轻油馏分中蒸馏切取的160-215℃的馏分，大致含苯乙烯6%、古马隆4%、茚40%、4-甲基苯乙烯5%和少量二甲苯、甲苯等化合物，树脂总量占原料的60-70%。在氯化铝、氟化硼或者浓硫酸等催化剂作用下，将茚、古马隆馏分在加压或不加压下聚合，即生成茚-古马隆树脂。
【用途三】
除少量用于有机溶剂和杀虫剂的中间体外，主要用于生产茚-古马隆树脂。

茚名称

[ CAS 号 ]:
95-13-6

[ 中文名 ]:
茚

[ 英文名 ]:
Indene

[英文别名 ]:

kannit
L56 BHJ
1H-Indene
(+)-xylitol
newtol
Klinit
Kylit
EINECS 202-393-6
Indene
Meso-X

茚物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
181.6±0.0 °C at 760 mmHg

[ 熔点 ]:
−5-−3 °C(lit.)

[ 分子式 ]:
C₉H₈

[ 分子量 ]:
116.160

[ 闪点 ]:
58.9±0.0 °C

[ 精确质量 ]:
116.062599

[ LogP ]:
2.91

[ 外观性状 ]:
淡黄色至橙色液体

[ 蒸汽压 ]:
1.2±0.2 mmHg at 25°C

[ 折射率 ]:
1.596

[ 储存条件 ]:
包装完整、轻装轻放,库房通风、远离明火、高温、与氧化剂分开存放

[ 稳定性 ]:
Stable, but air and light sensitive; may polymerize upon exposure to light. Typically contains aroung 80 - 100 ppm of p-tert-butylcatechol as inhibitor. Refrigerate. Flammable. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
INSOLUBLE

茚MSDS

详细MSDS(安全技术说明书)

茚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK8225000

CHEMICAL NAME :: Indene

CAS REGISTRY NUMBER :: 95-13-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C9-H8

MOLECULAR WEIGHT :: 116.17

WISWESSER LINE NOTATION :: L56 BHJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14 gm/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 39(4),86,1974 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/m3/24H/15W-C

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 41(4),104,1976 *** REVIEWS *** ACGIH TLV-TWA 48 mg/m3 (10 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (45 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,134,1971 OSHA PEL (Construc):8H TWA 10 ppm (45 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (45 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-BELGIUM:TWA 10 ppm (48 mg/m3) JAN 1993 OEL-DENMARK:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-FINLAND:TWA 10 ppm (47 mg/m3);STEL 20 ppm (95 mg/m3) JAN 1993 OEL-FRANCE:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 10 ppm (45 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 10 ppm (45 mg/m3);STEL 15 ppm (70 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO INDENE-air:10H TWA 10 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 39820 No. of Facilities: 3158 (estimated) No. of Industries: 24 No. of Occupations: 42 No. of Employees: 61824 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 39820 No. of Facilities: 31 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 753 (estimated) No. of Female Employees: 376 (estimated)

茚安全信息

[ 符号 ]:

GHS02, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H226-H304

[ 警示性声明 ]:
P301 + P310-P331

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R10;R65

[ 安全声明 (欧洲) ]:
S23-S24/25-S62

[ 危险品运输编码 ]:
UN 3295 3/PG 3

[ WGK德国 ]:
1

[ RTECS号 ]:
NK8225000

[ 包装等级 ]:
III

[ 危险类别 ]:
3

茚合成路线

详细合成路线

茚上下游产品

茚上游产品

茚下游产品

茚制备

在高温焦油中，茚含量0.25%-0.3%，主要存在于沸点168-175℃的煤焦油及粗苯馏分中，在200℃以前的重质苯中，古马隆和茚约占40%以上。以重苯为原料在具有44块理论塔板的分馏塔上进行精馏，控制回流比为15-20：1，切取塔顶温度为180.6-181.1℃馏分，含茚可达98%。另一种提取茚的方法，是以重苯和粗溶剂的油为原料，用糠醛作为共沸剂进行共沸蒸馏。由于糠醛或者甲醛能与重苯中烃类组分形成共沸物，但与茚不形成共沸物，因而可制取纯产品。

以重苯为原料在具有44块理论塔板的分馏塔上进行精馏，控制回流比为15-20：1，切取塔顶温度为180.6-181.1℃馏分，含茚可达98%。

高温下将四氢萘通过SiO2/A12O3也可制得。

茚文献

Fibronectin enhances spinal cord astrocyte proliferation by elevating P2Y1 receptor expression.

J. Neurosci. Res. 92(8) , 1078-90, (2014)

After spinal cord injury (SCI), the formation of glial scar is a complex process that is attributed primarily to astrocytic proliferation, but the mechanism of astrocytes proliferation is still unclea...

Decoys for docking.

J. Med. Chem. 48 , 3714-28, (2005)

Molecular docking is widely used to predict novel lead compounds for drug discovery. Success depends on the quality of the docking scoring function, among other factors. An imperfect scoring function ...

One pot synthesis of indene through copper(I)-catalyzed three-components coupling and cyclization reaction.

Org. Biomol. Chem. 10(18) , 3636-41, (2012)

A new and efficient synthesis of substituted indene has been achieved via copper(I)-catalyzed domino three-component coupling and cyclization reaction in moderate to good yield.

更多文献

茚

茚用途

茚名称