邻氯苯酚

邻氯苯酚用途

【用途一】
用于医药、农药和染料及其他有机合成原料
【用途二】
邻氯苯酚是杀虫剂丙溴磷的中间体。
【用途三】
用于有机合成。邻氯酚经光气化得到氯甲酸邻氯苯酯，是氨基甲酸酯类杀虫剂害扑威的中间体。
【用途四】
有机合成，染料制造，杀菌剂。
【用途五】
有机合成，染料制造，杀菌剂。用于ICP-AES、AAS、AFS、ICP-MS、离子色谱等。滴定分析用标准溶液。

邻氯苯酚名称

[ CAS 号 ]:
95-57-8

[ 中文名 ]:
邻氯苯酚

[ 英文名 ]:
2-Chlorophenol

[中文别名 ]:

[英文别名 ]:

o-Chlorphenol
ortho-chlorophenol
Phenol,2-chloro
chloro-2phenol
Chlorophenolate
septi-kleen
EINECS 202-433-2
o-chloro-pheno
Chlorophenol
Phenol, 2-chloro-

邻氯苯酚物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
175.0±0.0 °C at 760 mmHg

[ 熔点 ]:
8 °C(lit.)

[ 分子式 ]:
C₆H₅ClO

[ 分子量 ]:
128.556

[ 闪点 ]:
63.9±0.0 °C

[ 精确质量 ]:
128.002899

[ PSA ]:
20.23000

[ LogP ]:
2.04

[ 外观性状 ]:
无色至淡棕色液体

[ 蒸汽压 ]:
0.9±0.3 mmHg at 25°C

[ 折射率 ]:
1.576

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、食品添加剂分开存放

[ 稳定性 ]:
Stable. Hygroscopic. Combustible. Incompatible with oxidizing agents, acid anhydrides, acid chlorides.

[ 水溶解性 ]:
28.5 g/L (20 ºC)

邻氯苯酚MSDS

邻氯苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SK2625000

CHEMICAL NAME :: Phenol, o-chloro-

CAS REGISTRY NUMBER :: 95-57-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C6-H5-Cl-O

MOLECULAR WEIGHT :: 128.56

WISWESSER LINE NOTATION :: QR BG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 40 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - pulmonary emboli Liver - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3100 mg/m3/6H

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory stimulation Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 235 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1580 mg/kg

TOXIC EFFECTS :: Behavioral - food intake (animal) Lungs, Thorax, or Respiration - pulmonary emboli Liver - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - species unspecified

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Skin and Appendages - sweating

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2450 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4800 mg/kg/12W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4550 mg/kg

SEX/DURATION :: female 70 day(s) pre-mating female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Effects on Newborn - stillbirth

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 800 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84363 No. of Facilities: 23 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 495 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84363 No. of Facilities: 158 (estimated) No. of Industries: 2 No. of Occupations: 4 No. of Employees: 974 (estimated) No. of Female Employees: 323 (estimated)

邻氯苯酚安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H411

[ 警示性声明 ]:
P273-P280

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R20/21/22;R51/53

[ 安全声明 (欧洲) ]:
S28-S61-S28A-S45-S36/37-S16-S7

[ 危险品运输编码 ]:
UN 2021 6.1/PG 3

[ WGK德国 ]:
2

[ RTECS号 ]:
SK2625000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2908199090

邻氯苯酚合成路线

邻氯苯酚上下游产品

邻氯苯酚上游产品

邻氯苯酚下游产品

邻氯苯酚制备

1、（1）由苯酚钠经氯化、酸化而得。搅拌苯酚钠、水及冰的混合物，于20℃以下慢慢加次氯酸钠溶液，控制温度在20℃以下，室温放置过夜，搅拌下加浓盐酸酸化至pH为2，水洗一次，再用5%碳酸钠溶液洗至洗液pH为4-5，冷却后，分出油层，进行常压分馏，再经减压蒸馏而得成品。（2）由苯酚用氯气氯化。在搅拌下将熔融的苯酚加入苯中，在26±2℃通入氯气，至氯化液相对密度达0.954（23-25℃）为止。排除氯化氢后将苯蒸出回收，蒸至125℃（21.3kPa），冷却至60℃，减压分馏，收集75℃（2.67-3.33kPa）馏分即得邻氯苯酚。氯化反应同时也生成对氯苯酚及2,4-二氯苯酚，在减压分馏时作为高沸物收集，经分离可作为副产物。邻氯苯酚（95%以上）收率近50%，对氯苯酚（95%以上）收率约为25.5%。

2、邻氯苯酚是生产对氯苯酚的联产品，用苯酚氯化得到的是邻位和对位的氯代苯酚，经分离可以得到对氯苯酚和邻氯苯酚。

邻氯苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

邻氯苯酚文献

cIEF for rapid pKa determination of small molecules: a proof of concept.

Eur. J. Pharm. Sci. 63 , 14-21, (2014)

A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) w...

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols.

Molecules 20 , 11554-68, (2015)

Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were equal or more potent (1.0-6.6 times) than ...

The JNK1/JNK3 interactome--contributions by the JNK3 unique N-terminus and JNK common docking site residues.

Biochem. Biophys. Res. Commun. 453(3) , 576-81, (2014)

The c-Jun N-terminal Kinases (JNKs) play important roles in cell responses to stress or growth factor stimulation. The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform,...

更多文献