哒螨灵_MSDS_用途_密度_哒螨灵CAS号【96489-71-3】

吡达本是一种METI杀螨剂,可抑制复合物I(METI；大鼠脑线粒体中Ki=0.36 nmol/mg蛋白质)的线粒体电子传递。吡达本对多种螨虫有活性,分别以25、100和200毫克/立方米的剂量通过滤纸接触给药,可导致马来丝虫、法氏锥虫和腐败T.的100%死亡率。

[ 描述 ]:

吡达本是一种METI杀螨剂,可抑制复合物I(METI；大鼠脑线粒体中Ki=0.36 nmol/mg蛋白质)的线粒体电子传递。吡达本对多种螨虫有活性,分别以25、100和200毫克/立方米的剂量通过滤纸接触给药,可导致马来丝虫、法氏锥虫和腐败T.的100%死亡率。

[ 密度 ]:
1.12 g/cm3

[ 沸点 ]:
429.9ºC at 760 mmHg

[ 熔点 ]:
111-112ºC

[ 分子式 ]:
C₁₉H₂₅ClN₂OS

[ 分子量 ]:
364.93300

[ 闪点 ]:
213.8ºC

[ 精确质量 ]:
364.13800

[ PSA ]:
60.19000

[ LogP ]:
5.24150

[ 外观性状 ]:
白色固体

[ 折射率 ]:
1.564

[ 储存条件 ]:
0-6°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UR6149000

CHEMICAL NAME :: 3(2H)-Pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylet hyl)phenyl)methyl) thio)-

CAS REGISTRY NUMBER :: 96489-71-3

LAST UPDATED :: 199606

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C19-H25-Cl-N2-O-S

MOLECULAR WEIGHT :: 364.97

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 570 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 620 mg/m3

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),12,1993

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C269,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 58100 ug/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 205 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),12,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3494 mg/kg/2Y-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10 mg/m3/6H/4W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 983 mg/kg/13W-C

TOXIC EFFECTS :: Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5242 mg/kg/78W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 364 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1484 mg/kg/53W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 300 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S203,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 210 mg/kg

SEX/DURATION :: female 6-19 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects

REFERENCE :: NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S203,1994

[ 符号 ]:

GHS06, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H331-H410

[ 警示性声明 ]:
P261-P273-P301 + P310-P311-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
T:Toxic;N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R23/25;R50/53

[ 安全声明 (欧洲) ]:
S36/37-S45-S60-S61

[ 危险品运输编码 ]:
UN 3077

[ RTECS号 ]:
UR6149000

[ 包装等级 ]:
II

[ 危险类别 ]:
6.1(a)

[ 海关编码 ]:
2933399027

哒螨灵上游产品

哒螨灵下游产品

1.对特丁基基苄硫醇的制备对特丁基甲苯在偶氮二异丁腈存在下，于68～72℃通氯氯化6h，得对特丁基氯苄；然后将精制的对特丁基氯苄以甲苯为溶剂，在四丁基溴化铵和醋酸的存在下，滴加23%硫氢化钠水溶液，滴毕后于50℃继续反应30min，经后处理得对特丁基苄硫醇，收率92%。
2. 2-特丁基-4，5-二氯-3-（2H）-哒嗪酮的制备将糠醛与浓盐酸混合，于90～100℃通氯气氯化，得糠氯酸，收率87%；将盐酸肼与特丁基醇于82～105℃反应得特丁基肼盐酸盐，收率97%；然后将特丁基肼盐酸盐溶于5%NaOH溶液，于0～5℃加长糠氯酸四氢呋喃溶液反应30min，再升温至10～15℃反应30min，得糖氯酸特丁基腙，收率87%；再在苯和醋酸存在下，糠氯酸特丁基腙加热至35～45℃，反应4h，缩合、环合生成2-特丁基-4，5-二氯-3（2H）-哒嗪酮，收率98%。
3.哒螨灵的合成将2-特丁基-4，5-二氢-3（2H）-哒嗪酮和对特丁基苄硫醇，以甲醇为溶剂，再在0℃加入甲醇钠甲醇溶液，于10～15℃搅拌反应1h，经后处理得哒螨灵，m.p.111～112℃，收率96%。

制备方法二

制备方法三

[ 海关编码 ]: 2933399027

[ 中文概述 ]:
2933399027 甲基毒死蜱,吡虫啉等〔包括吡氯氰菊酯,啶蜱脲,氟啶脲,哒幼酮,吡丙醚〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933399027 2-(tert-butyl)-5-((4-(tert-butyl)benzyl)thio)-4-chloropyridazin-3(2h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

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公司名：上海化源世纪贸易有限公司

区域：上海市普陀区

价格：

联系人：徐经理

产品详情：哒螨灵

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥198.0/1ml

联系人：刘佳

产品详情：哒螨灵

公司名：上海源溪生物科技有限公司

区域：上海市浦东新区

价格：
￥需询单/1g

联系人：赖经理

产品详情：Pyridaben

公司名：上海脉铂医药科技有限公司

区域：上海市嘉定区

价格：
￥311.0/25mg ￥1120.0/100mg ￥591.0/50mg ￥需询单/1g

联系人：李先生

产品详情：Pyridaben

公司名：上海阿拉丁生化科技股份有限公司

区域：上海市浦东新区

价格：
￥133.9/1ml ￥257.9/1ml ￥308.9/250mg ￥990.9/1g

联系人：阿拉丁

产品详情：甲醇中哒螨灵溶液标准物质

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哒螨灵属哒嗪酮类杀虫、杀螨剂，有效成分为哒螨灵，在PH为4～9的条件下稳定，对光相对不稳定。乳油在常规条件下至少保存2年。对人、畜低毒，对眼有轻微刺激作用，对蜜蜂、家蚕有毒，对鱼为中等毒性。对害螨具有触杀作用，无内吸传导和薰蒸作用，对成螨、若螨及卵都有效，速效性好，而且药效不受温度影响，与常规杀螨...

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