96489-71-3

• 常用中文名：哒螨灵
• 常用英文名：Pyridaben
• CAS号：96489-71-3
• 分子式：C₁₉H₂₅ClN₂OS
• 分子量：364.93300
• 相关类别： 化学农药原药 杀虫剂 杀螨剂
• 发布时间：2018-09-22 18:13:20
• 更新时间：2024-01-02 12:32:55
• 吡达本是一种METI杀螨剂,可抑制复合物I(METI；大鼠脑线粒体中Ki=0.36 nmol/mg蛋白质)的线粒体电子传递。吡达本对多种螨虫有活性,分别以25、100和200毫克/立方米的剂量通过滤纸接触给药,可导致马来丝虫、法氏锥虫和腐败T.的100%死亡率。

名称

• 中文名: 哒螨灵
• 英文名: pyridaben
• 中文别名: 哒螨净; 特螨酮; 速螨酮; 2-特丁基-5-(4-特丁基苄硫基)-4-氯-2H-哒嗪-3-酮; 达螨灵：扫螨净; 哒螨酮; 速螨灵; 2-特丁基-5-(4-特丁基苄硫基-4-氯-3(H)-哒嗪-3-酮
• 英文别名: Sanmite; NCI 129; 2-tert-butyl-5-{[(4-tert-butylphenyl)methyl]sulfanyl}-4-chloropyridazin-3(2H)-one; 2-tert-butyl-5-(4-tert-butylbenzylthio)-4-chloropyridazin-3(2H)-one; 4-chloro-2-(1,1-dimethylethyl)-5-[[[4-(1,1-dimethylethyl)phenyl]methyl]thio]-3(2H)-pyridazinone; MFCD00274601; 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-3(2H)-pyridazinone; 2-tert-butyl-4-chloro-5-(4-tert-butyl-benzylthio)-3(2H)-pyridazinone; 2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one; 2-t-butyl-5-(p-t-butylbenzylthio)-4-chloro-3(2H)-pyridazinone; Pyridaben [ISO]; Pyridaben; EINECS 405-700-3

物化性质

• 密度: 1.12 g/cm3
• 沸点: 429.9ºC at 760 mmHg
• 熔点: 111-112ºC
• 分子式: C₁₉H₂₅ClN₂OS
• 分子量: 364.93300
• 闪点: 213.8ºC
• 精确质量: 364.13800
• PSA: 60.19000
• LogP: 5.24150
• 外观性状: 白色固体
• 折射率: 1.564
• 储存条件:

  密封储存，储存于阴凉、干燥的库房。远离热源，火焰。

• 稳定性:

  常温常压下稳定，避免与强氧化剂接触。对眼和皮肤无刺激性，对豚鼠皮肤无致敏性。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:5.2

  2.氢键供体数量:0

  3.氢键受体数量:3

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积58

  7.重原子数量:24

  8.表面电荷:0

  9.复杂度:535

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：黄褐色有微弱香草气味粉末

  2. 密度（g/mL,25℃）：1.22

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：111～112

  5. 沸点（ºC,常压）：430

  6. 沸点（ºC，2mmHg）：未确定

  7. 折射率(n20/D)：未确定

  8. 闪点（ºC）：214

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：394

  11. 蒸气压（mmHg,20ºC）：未确定

  12. 饱和蒸气压（kPa,25ºC）：未确定

  13. 燃烧热（KJ/mol）：68.5

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：不溶于水

生物活性

• 描述: 吡达本是一种METI杀螨剂,可抑制复合物I(METI；大鼠脑线粒体中Ki=0.36 nmol/mg蛋白质)的线粒体电子传递。吡达本对多种螨虫有活性,分别以25、100和200毫克/立方米的剂量通过滤纸接触给药,可导致马来丝虫、法氏锥虫和腐败T.的100%死亡率。

MSDS

Section1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE Product identifiers Product name: Pyridaben CAS-No.: 96489-71-3 Relevant identified uses of the substance or mixture and uses advised against Identified uses: Laboratory chemicals, Manufacture of substances Section2. HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Inhalation (Category 3) Acute toxicity, Oral (Category 3) Acute aquatic toxicity (Category 1) Chronic aquatic toxicity (Category 1) Classification according to EU Directives 67/548/EEC or 1999/45/EC Toxic by inhalation and if swallowed. Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal wordDanger Hazard statement(s) H301Toxic if swallowed. H331Toxic if inhaled. H410Very toxic to aquatic life with long lasting effects. Precautionary statement(s) P261Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray. P273Avoid release to the environment. P301 + P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P311Call a POISON CENTER or doctor/ physician. P501Dispose of contents/ container to an approved waste disposal plant. Supplemental Hazardnone Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R23/25Toxic by inhalation and if swallowed. R50/53Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. S-phrase(s) S36/37Wear suitable protective clothing and gloves. S45In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S60This material and its container must be disposed of as hazardous waste. S61Avoid release to the environment. Refer to special instructions/ Safety data sheets. Other hazards - none Section3. COMPOSITION/INFORMATION ON INGREDIENTS Substances Formula: C19H25ClN2OS Molecular Weight: 364,93 g/mol ComponentConcentration 2-tert-Butyl-5-(4-tert-butylbenzylthio)-4-chloro-pyridazine-3(2H)-one CAS-No.96489-71-3- EC-No.405-700-3 Index-No.613-149-00-7 Section4. FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Indication of any immediate medical attention and special treatment needed no data available Section5. FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas Nature of decomposition products not known. Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available Section6. ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. Section7. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Specific end uses no data available Section8. EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Section9. PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) AppearanceForm: solid b) Odourno data available c) Odour Thresholdno data available d) pHno data available e) Melting point/freezingno data available point f) Initial boiling point and no data available boiling range g) Flash pointno data available h) Evaporation rateno data available i) Flammability (solid, gas) no data available j) Upper/lowerno data available flammability or explosive limits k) Vapour pressureno data available l) Vapour densityno data available m) Relative densityno data available n) Water solubilityno data available o) Partition coefficient: n- no data available octanol/water p) Autoignitionno data available temperature q) Decompositionno data available temperature r) Viscosityno data available s) Explosive propertiesno data available t) Oxidizing propertiesno data available Other safety information no data available Section10. STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid no data available Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available Section11. TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity LD50 Oral - mouse - 205 mg/kg Remarks: Behavioral:Somnolence (general depressed activity). Respiratory disorder Skin and Appendages: Other: Hair. LC50 Inhalation - rat - 620 mg/m3 LD50 Dermal - rabbit - > 2.000 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC:No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity Reproductive toxicity - rat - Oral Maternal Effects: Other effects. Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord). Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation Toxic if inhaled. May cause respiratory tract irritation. IngestionToxic if swallowed. Skin May be harmful if absorbed through skin. May cause skin irritation. EyesMay cause eye irritation. Additional Information RTECS: UR6149000 Section12. ECOLOGICAL INFORMATION Toxicity Toxicity to fishLC50 - Oncorhynchus mykiss (rainbow trout) - 0,72 µg/l - 96,0 h Toxicity to daphnia and EC50 - Daphnia magna (Water flea) - 0,53 µg/l - 48 h other aquatic invertebrates Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects Very toxic to aquatic life with long lasting effects. Section13. DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. Section14. TRANSPORT INFORMATION UN number ADR/RID: 3077IMDG: 3077IATA: 3077 UN proper shipping name ADR/RID: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (2-tert-Butyl-5-(4-tert- butylbenzylthio)-4-chloro-pyridazine-3(2H)-one) IMDG: ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (2-tert-Butyl-5-(4-tert- butylbenzylthio)-4-chloro-pyridazine-3(2H)-one) IATA:Environmentally hazardous substance, solid, n.o.s. (2-tert-Butyl-5-(4-tert-butylbenzylthio)-4- chloro-pyridazine-3(2H)-one) Transport hazard class(es) ADR/RID: 9IMDG: 9IATA: 9 Packaging group ADR/RID: IIIIMDG: IIIIATA: III Environmental hazards ADR/RID: yesIMDG Marine pollutant: yesIATA: yes Special precautions for user Further information EHS-Mark required (ADR 2.2.9.1.10, IMDG code 2.10.3) for single packagings and combination packagings containing inner packagings with Dangerous Goods > 5L for liquids or > 5kg for solids. Section15. REGULATORY INFORMATION This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available Section16. OTHER INFORMATION Further information Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

毒性和生态

毒理学数据: 雄大鼠急性经口LD50为1350mg/kg,雌性为820mg /kg;小鼠急性经口358-435mg/kg;大鼠急性吸入工_(、为0. 62-0. 66mg/L;大鼠和兔急LD50>2000mg /kg 。2年慢性毒性试验为28mg/kg.Ames、试验、DNA修复、离体染色体畸变、小鼠微核试验均为阴性。鹤鹑急性经口LD50>2250mg /kg >野鸭为2500mg /kg >鲤鱼LC50 < 0.5mg/L(48h)>蜜蜂经口LD50为0.55μg/只(24h). CHEMICAL IDENTIFICATION RTECS NUMBER : UR6149000 CHEMICAL NAME : 3(2H)-Pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylet hyl)phenyl)methyl) thio)- CAS REGISTRY NUMBER : 96489-71-3 LAST UPDATED : 199606 DATA ITEMS CITED : 14 MOLECULAR FORMULA : C19-H25-Cl-N2-O-S MOLECULAR WEIGHT : 364.97 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 570 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 620 mg/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),12,1993 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C269,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 58100 ug/kg TOXIC EFFECTS : Behavioral - muscle weakness Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 205 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Skin and Appendages - hair REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AGJAEP Agrochemcicals Japan. (Japan Plant Protection Association, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.62- 1993- Volume(issue)/page/year: (63),12,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3494 mg/kg/2Y-C TOXIC EFFECTS : Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : TCLo - Lowest published toxic concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/m3/6H/4W-I TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 983 mg/kg/13W-C TOXIC EFFECTS : Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5242 mg/kg/78W-C TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 364 mg/kg/13W-I TOXIC EFFECTS : Gastrointestinal - changes in structure or function of salivary glands Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1484 mg/kg/53W-I TOXIC EFFECTS : Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S243,1994 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 300 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S203,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 210 mg/kg SEX/DURATION : female 6-19 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 19,S203,1994

安全

• 符号: GHS06, GHS09
• 信号词: Danger
• 危害声明: H301-H331-H410
• 警示性声明: P261-P273-P301 + P310-P311-P501
• 个人防护装备: Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
• 危害码 (欧洲): T:Toxic;N:Dangerousfortheenvironment;
• 风险声明 (欧洲): R23/25;R50/53
• 安全声明 (欧洲): S36/37-S45-S60-S61
• 危险品运输编码: UN 3077
• RTECS号: UR6149000
• 包装等级: II
• 危险类别: 6.1(a)
• 海关编码: 2933399027

合成路线

19692-45-6 96490-18-5 ~85% 96489-71-3

文献：Nissan Chemical Industries Patent: US4877787 A1, 1989 ;

18880-00-7 96490-18-5 ~% 96489-71-3

文献：US2005/191238 A1, ; Page/Page column 50 ;

上下游产品

上游产品  3
19692-45-6 96490-18-5 18880-00-7
下游产品  0

制备

1.对特丁基基苄硫醇的制备 对特丁基甲苯在偶氮二异丁腈存在下，于68～72℃通氯氯化6h，得对特丁基氯苄；然后将精制的对特丁基氯苄以甲苯为溶剂，在四丁基溴化铵和醋酸的存在下，滴加23%硫氢化钠水溶液，滴毕后于50℃继续反应30min，经后处理得对特丁基苄硫醇，收率92%。
2. 2-特丁基-4，5-二氯-3-（2H）-哒嗪酮的制备 将糠醛与浓盐酸混合，于90～100℃通氯气氯化，得糠氯酸，收率87%；将盐酸肼与特丁基醇于82～105℃反应得特丁基肼盐酸盐，收率97%；然后将特丁基肼盐酸盐溶于5%NaOH溶液，于0～5℃加长糠氯酸四氢呋喃溶液反应30min，再升温至10～15℃反应30min，得糖氯酸特丁基腙，收率87%；再在苯和醋酸存在下，糠氯酸特丁基腙加热至35～45℃，反应4h，缩合、环合生成2-特丁基-4，5-二氯-3（2H）-哒嗪酮，收率98%。
3.哒螨灵的合成 将2-特丁基-4，5-二氢-3（2H）-哒嗪酮和对特丁基苄硫醇，以甲醇为溶剂，再在0℃加入甲醇钠甲醇溶液，于10～15℃搅拌反应1h，经后处理得哒螨灵，m.p.111～112℃，收率96%。

制备方法二

制备方法三

海关

海关编码	2933399027
中文概述	2933399027 甲基毒死蜱,吡虫啉等〔包括吡氯氰菊酯,啶蜱脲,氟啶脲,哒幼酮,吡丙醚〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
监管条件	S.进出口农药登记证明
Summary	2933399027 2-(tert-butyl)-5-((4-(tert-butyl)benzyl)thio)-4-chloropyridazin-3(2h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%