2-甲氧基-4-硝基苯胺

2-甲氧基-4-硝基苯胺用途

【用途一】
主要用于棉纤维织物的染色和印花显色，也用于制造快色素、枣红、金黄、黑等有机颜料
【用途二】
该品为冰染染料色基，主要用作棉纤维织物的染色的印花显色剂，也用于制造快色素、枣红、金黄、黑等有机颜料。
【用途三】
用于合成颜料黄74#。棉纤维蜡染。

2-甲氧基-4-硝基苯胺名称

[ CAS 号 ]:
97-52-9

[ 中文名 ]:
红色基B

[ 英文名 ]:
4-Nitro-o-anisidine

[中文别名 ]:

[英文别名 ]:

2-METHOXY-4-NITROANILINE/4-NITRO-O-ANISIDINE
EINECS 202-588-6
2-Amino-5-nitroanisole
2-amino-5-nitroanisol
2-methoxy-4nitro-aniline
4-Nitro-o-anisidine
KERNECHTROT SALT B
2-Methoxy-4-nitrobenzenamine
2-METHOXY-4-NITRO-ANILINE 97-52-9
2-Methoxy-4-nitroaniline

2-甲氧基-4-硝基苯胺物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
364.2±22.0 °C at 760 mmHg

[ 熔点 ]:
140-142 °C(lit.)

[ 分子式 ]:
C₇H₈N₂O₃

[ 分子量 ]:
168.150

[ 闪点 ]:
174.0±22.3 °C

[ 精确质量 ]:
168.053497

[ PSA ]:
81.07000

[ LogP ]:
1.85

[ 外观性状 ]:
淡黄色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.601

[ 储存条件 ]:
库房通风低温干燥,与食品原料分开储运

[ 水溶解性 ]:
slightly soluble

2-甲氧基-4-硝基苯胺MSDS

2-甲氧基-4-硝基苯胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BZ7170000

CHEMICAL NAME :: o-Anisidine, 4-nitro-

CAS REGISTRY NUMBER :: 97-52-9

BEILSTEIN REFERENCE NO. :: 0879619

LAST UPDATED :: 199710

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C7-H8-N2-O3

MOLECULAR WEIGHT :: 168.17

WISWESSER LINE NOTATION :: WNR DZ C01

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 997 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,717,1986 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0147 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 523 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0147 No. of Facilities: 70 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 198 (estimated) No. of Female Employees: 80 (estimated)

2-甲氧基-4-硝基苯胺安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22

[ 安全声明 (欧洲) ]:
S26-S37/39-S36/37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
BZ7170000

[ 危险类别 ]:
6.1

[ 海关编码 ]:
29222900

2-甲氧基-4-硝基苯胺合成路线

2-甲氧基-4-硝基苯胺上下游产品

2-甲氧基-4-硝基苯胺上游产品

2-甲氧基-4-硝基苯胺下游产品

2-甲氧基-4-硝基苯胺制备

邻甲氧基苯胺用对甲基苯磺酰氯在碳酸钠存在下缩合而得N-对甲苯磺酰邻甲氧基苯胺，再用硝酸硝化得4-硝基-2-甲氧基-N-对甲苯磺酰基苯胺，硝化物用稀硫酸处理，水解以脱去对甲基苯磺酰基，而得成品。将邻甲氧基苯胺和等摩尔的对甲基苯磺酰氯加入85℃的水中，加碳酸钠调整反应液pH值得8。到达反应终点后冷却至60℃，用硫酸调整pH至6，再冷却至45℃，过滤得N-对甲苯磺酰邻甲氧基苯胺，收率为99%。在硝化锅内加入氯苯，投入上述缩合产物。在30-33℃搅拌加入亚硝酸钠，再缓缓加入82%的硝酸，加料温度不超过50℃。15min左右冷却至35℃，再按比例投入缩合产物及硝酸，加料时间为3.5h，反应温度控制在35-45℃。加完后再在50℃反应1.5h。冷却至30℃过滤，滤饼先后用氯苯和水洗涤，干燥得4-硝基-2-甲氧基-N-对甲苯磺酰基苯胺，收率为85%。将此硝化物加入78℃的82%-83%硫酸中，加完后于90℃保温2.5h。用水稀释后加碱中和至pH值为7.5，于30℃压滤，依次用5%纯碱溶液和水洗涤，干燥，得2-甲氧基-4-硝基苯胺，收率为95%。所得产品为黄色或黄褐色粉末。含量（干基）≥98%。原料消耗定额：邻甲氧基苯胺960kg/t、对甲苯磺酰氯1540kg/t。

2-甲氧基-4-硝基苯胺海关

[ 海关编码 ]: 2922299090

[ 中文概述 ]:
2922299090. 其他氨基(萘酚、酚)及醚、酯〔包括它们的盐, 但含有一种以上含氧基的除外〕. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

2-甲氧基-4-硝基苯胺文献

2-Methoxy-4-nitroaniline is a selective inducer of cytochrome P450IA2 (CYP1A2) in rat liver.

Cancer Lett. 96(1) , 95-8, (1995)

Male F344 rats were treated with a chemical (aniline, nitrobenzene, 2-methoxy-p-phenylenediamine, 2-methoxy-4-nitroaniline or 2-methoxy-4-nitroazobenzene) produced by the azo-reduction and/or N-oxidat...

Metabolism and disposition of 2-methoxy-4-nitroaniline in male and female Harlan Sprague Dawley rats and B6C3F1/N mice.

Xenobiotica 42(12) , 1213-24, (2012)

The disposition of 2-Methoxy-4-nitroaniline (MNA) was investigated in male and female Harlan Sprague Dawley rats and B6C3F(1)/N mice following oral, intravenous, and dermal exposure to [(14)C]MNA at 2...

Use of nitroanilines for spectrophotometric determination of ethinylestradiol in pharmaceutical formulations. Leonardo SG, et al.

Anal. Methods 3(5) , 1198-1201, (2011)

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