alpha-松油醇

alpha-松油醇用途

α-Terpineol 从蓝桉 (Eucalyptus globulus Labill) 中分离出来,对牙周病和致龋菌具有很强的抗菌活性。 α-Terpineol 具有抗真菌活性 T. mentagrophytes,这种活性可能导致不可逆转的细胞分裂。

alpha-松油醇名称

[ CAS 号 ]:
98-55-5

[ 中文名 ]:
α-松油醇

[ 英文名 ]:
Terpineol

[中文别名 ]:

[英文别名 ]:

TERPINENOL
2-(4-Methyl-3-cyclohexen-1-yl)-2-propanol
alpha-terpineol
pc593
MFCD00001557
3-Cyclohexene-1-methanol, α,α,4-trimethyl-
TILIANOL NP
A-TERPINEOL
EINECS 232-268-1
TERPINEOL BP

alpha-松油醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

研究领域 >> 炎症/免疫

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Park SN, et al. Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria. Anaerobe. 2012 Jun;18(3):369-72.

[2]. Park MJ, et al. Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. Fitoterapia. 2009 Jul;80(5):290-6.

alpha-松油醇物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
217.5±0.0 °C at 760 mmHg

[ 熔点 ]:
31-34ºC

[ 分子式 ]:
C₁₀H₁₈O

[ 分子量 ]:
154.249

[ 闪点 ]:
89.4±0.0 °C

[ 精确质量 ]:
154.135757

[ PSA ]:
20.23000

[ LogP ]:
2.79

[ 外观性状 ]:
无色至淡黄色晶体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.483

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
negligible

alpha-松油醇MSDS

alpha-松油醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WZ6700000

CHEMICAL NAME :: alpha-Terpineol

CAS REGISTRY NUMBER :: 98-55-5

BEILSTEIN REFERENCE NO. :: 1906604

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H18-O

MOLECULAR WEIGHT :: 154.28

WISWESSER LINE NOTATION :: L6UTJ A1 DXQ1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5170 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(2),29,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2830 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 33,1669,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 21,342,1962 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7755 mg/kg/30D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(2),29,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80268 No. of Facilities: 2241 (estimated) No. of Industries: 37 No. of Occupations: 47 No. of Employees: 16136 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80268 No. of Facilities: 20420 (estimated) No. of Industries: 125 No. of Occupations: 102 No. of Employees: 328085 (estimated) No. of Female Employees: 125759 (estimated)

alpha-松油醇安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R38

[ 安全声明 (欧洲) ]:
S37

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
WZ6700000

[ 海关编码 ]:
29061400

alpha-松油醇合成路线

alpha-松油醇上下游产品

alpha-松油醇上游产品

alpha-松油醇下游产品

alpha-松油醇制备

1.以异戊二烯与丁烯酮经缩合反应，然后与格氏试剂反应制得；或由松节油中的蒎烯在30%的硫酸作用下生成水合萜二醇结晶沉淀，分离后经脱水、分离、蒸馏得成品。

2.从长叶松中分离提取。

alpha-松油醇海关

[ 海关编码 ]: 2906199090

[ 中文概述 ]:
2906199090. 其他环烷醇，环烯醇及环萜烯醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

alpha-松油醇文献

Terpinen-4-ol and alpha-terpineol (tea tree oil components) inhibit the production of IL-1β, IL-6 and IL-10 on human macrophages.

Inflamm. Res. 63(9) , 769-78, (2014)

Tea tree oil (TTO) is an essential oil with anti-inflammatory properties, steam distilled from the plant Melaleuca alternifolia. We investigated the immunomodulatory properties of TTO and its componen...

Activation of human 5-hydroxytryptamine type 3 receptors via an allosteric transmembrane site.

Mol. Pharmacol. 87(1) , 87-95, (2015)

In common with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 receptors (5-HT3Rs) are activated by the binding of a neurotransmitter to an ext...

Evaluation of the antioxidant and antiproliferative potential of bioflavors

Food Chem. Toxicol. 49(7) , 1610-5, (2011)

Highlights ► Antioxidant potential and antiproliferative effect of five monoterpenes was investigated. ► α-Terpineol presented good antioxidant activity in ORAC test. ► Limonene and α-terpineol presen...

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