<生产厂家价格>

2-吡啶甲酸

2-吡啶甲酸用途

PCL 016是一种局部抗病毒药物,兔子中发现能够抑制腺病毒复制。

2-吡啶甲酸名称

[ CAS 号 ]:
98-98-6

[ 中文名 ]:
2-吡啶甲酸

[ 英文名 ]:
2-Picolinic acid

[中文别名 ]:

[英文别名 ]:

2-pyridinecarboxylic acid
Picolinic acid
pyridine-2-carboxylic acid
acidepicolique
EINECS 202-719-7
2-Carboxypyridine
MFCD00006293
2-acid pyridine
2-Picolinic acid
Sorafenib Impurity 18

2-吡啶甲酸生物活性

[ 描述 ]:

PCL 016是一种局部抗病毒药物,兔子中发现能够抑制腺病毒复制。

[ 相关类别 ]:

天然产物 >> 其他

研究领域 >> 感染

[ 靶点 ]

Human Endogenous Metabolite

[体内研究]

局部1.5％PCL,0.8％PCL,0.369％PCL(pH7),0.369％PCL(pH4)和0.5％CDV在降低Ad阳性培养物/总量(第1-14天)和持续时间方面明显比对照更有效。 Ad5/NZW兔眼模型中的广告脱落。虽然没有统计学意义,但似乎存在PCL 016对Ad Shedding持续时间的浓度依赖性功效的趋势。 PCL 016浓度没有明显的眼部毒性[1]。

[动物实验]

兔子[1] 25只NZW兔在角膜划痕后用双眼局部接种，用1.5×106pfu /眼Ad5。在第1天，将兔子分成6个局部治疗组：I-1.5％PCL 016 pH 7.0（n = 4）; II - 0.8％PCL 016 pH 7.0（n = 4）; III-0.369％PCL 016 pH 7.0（n = 4）; IV - 0.369％PCL 016 pH 4.0（n = 4）; V - 0.5％西多福韦（CDV）（n = 4）; VI-对照（盐水）（n = 5）。 PCL 016和对照兔在两只眼睛中每天处理4次，持续7天，而CDV兔在两只眼睛中每天处理两次，持续7天。在第0,1,3,4,5,7,9,11和14天将所有眼睛培养成病毒[1]。

[参考文献]

[1]. E.G. Romanowski, et al. A Novel Topical Antiviral Agent, PCL–016 (Picolinic Acid), Inhibits Adenovirus Replication in the Ad5/NZW Rabbit Ocular Model. ARVO Annual Meeting Abstract. May 2005 Volume 46, Issue 13.

[相关活性小分子]

2-吡啶甲酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
292.5±13.0 °C at 760 mmHg

[ 熔点 ]:
139-142 °C(lit.)

[ 分子式 ]:
C₆H₅NO₂

[ 分子量 ]:
123.109

[ 闪点 ]:
130.7±19.8 °C

[ 精确质量 ]:
123.032028

[ PSA ]:
50.19000

[ LogP ]:
-0.10

[ 外观性状 ]:
白色针状结晶。熔点134-136℃，易溶于冰乙酸，几乎不溶于乙醚、氯仿和二硫化碳。

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.571

[ 储存条件 ]:
Store at RT.

[ 水溶解性 ]:
887 g/L (20 ºC)

2-吡啶甲酸MSDS

详细MSDS(安全技术说明书)

2-吡啶甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TJ7344000

CHEMICAL NAME :: Picolinic acid

CAS REGISTRY NUMBER :: 98-98-6

BEILSTEIN REFERENCE NO. :: 0109595

LAST UPDATED :: 199710

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C6-H5-N-O2

MOLECULAR WEIGHT :: 123.12

WISWESSER LINE NOTATION :: T6NJ BVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 360 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 17,2377,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 487 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1343,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: 562 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 178 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 295 gm/kg/8D-I

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes

REFERENCE :: ETPAEK Experimental and Toxicologic Pathology. (Gustav Fischer Verlag Jena, Postfach 100537, D-07705 Jena, Germany) V.44- 1992- Volume(issue)/page/year: 47,25,1995

2-吡啶甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H319

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn,Xi

[ 风险声明 (欧洲) ]:
R22:Harmful if swallowed. R36:Irritating to the eyes. R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36-S33-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TJ7344000

[ 海关编码 ]:
29333999

2-吡啶甲酸合成路线

详细合成路线

2-吡啶甲酸上下游产品

2-吡啶甲酸上游产品

2-吡啶甲酸下游产品

2-吡啶甲酸制备

将50g2-甲基吡啶加入2500ml水中，加热搅拌，加入90g高锰酸钾，约1h后再加入第二份90g高锰酸钾。补加500ml水并继续加热2-2.5h，直至紫色消失。冷却，滤出二氧化锰沉淀，用热水洗涤。将滤液减压浓缩，过滤。浓缩液用浓盐酸酸化至刚果红酸性后蒸发至干，将其与250ml95%乙醇检煮回流1h。过滤，滤饼用95%乙醇提取，合并乙醇滤液及提取液，通入干燥的氯化氢，至晶体开始析出为止。冷却至10℃，再通氯化氢至馏和，滤出吡啶甲酸盐酸盐，干燥后得43-44g（盐酸盐熔点210-212℃)。

2-吡啶甲酸海关

[ 海关编码 ]: 29333999

2-吡啶甲酸文献

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Nature 457(7231) , 910-4, (2009)

Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the i...

Interaction of vanadium(IV) with human serum apo-transferrin.

J. Inorg. Biochem. 121 , 187-95, (2013)

The interaction of V(IV)O-salts as well as of a few V(IV)O(carrier)n complexes with human serum transferrin (hTF) is studied focusing on the determination of the nature and stoichiometry of the bindin...

Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

J. Med. Chem. 54 , 591-602, (2011)

Fragment-based lead design (FBLD) has been used to identify new metal-binding groups for metalloenzyme inhibitors. When screened at 1 mM, a chelator fragment library (CFL-1.1) of 96 compounds produced...

更多文献