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1,3,5-三硝基苯

1,3,5-三硝基苯用途

用作炸药，在分析化学中用作pH值指示剂。

1,3,5-三硝基苯名称

[ CAS 号 ]:
99-35-4

[ 中文名 ]:
1,3,5-三硝基苯

[ 英文名 ]:
1,3,5-trinitrobenzene

[英文别名 ]:

EINECS 202-752-7
MFCD00059179
1,3,5-TRINITROBENZENE

1,3,5-三硝基苯物理化学性质

[ 密度 ]:
1.705g/cm3

[ 沸点 ]:
315ºC at 760mmHg

[ 熔点 ]:
122°C

[ 分子式 ]:
C₆H₃N₃O₆

[ 分子量 ]:
213.10500

[ 闪点 ]:
164.1ºC

[ 精确质量 ]:
213.00200

[ PSA ]:
137.46000

[ LogP ]:
2.98080

[ 折射率 ]:
1.655

[ 储存条件 ]:
轻装轻放,库房通风、远离明火、高温、阳光、与氧化剂、碱,食品原料分开存放

1,3,5-三硝基苯MSDS

1,3,5-三硝基苯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DC3850000

CHEMICAL NAME :: Benzene, 1,3,5-trinitro-

CAS REGISTRY NUMBER :: 99-35-4

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C6-H3-N3-O6

MOLECULAR WEIGHT :: 213.12

WISWESSER LINE NOTATION :: WNR CNW ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 275 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 572 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 730 mg/kg

TOXIC EFFECTS :: Brain and Coverings - other degenerative changes Lungs, Thorax, or Respiration - dyspnea Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3640 ug/kg/26W-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other esterases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 710 mg/kg/10D-I

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Brain and Coverings - demyelination Brain and Coverings - other degenerative changes

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2070 mg/kg/90D-C

TOXIC EFFECTS :: Endocrine - changes in spleen weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 355 mg/kg/10D-I

TOXIC EFFECTS :: Blood - normocytic anemia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 400 mg/kg/4D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 10 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 2,531,1980

1,3,5-三硝基苯安全信息

[ 符号 ]:

GHS01, GHS06, GHS08, GHS09

[ 信号词 ]:
Danger

[ 危害声明 ]:
H201-H300 + H310 + H330-H373-H410

[ 警示性声明 ]:
P260-P264-P273-P280-P284-P301 + P310

[ 靶器官 ]:
Blood, Central nervous system, Liver

[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ 危害码 (欧洲) ]:
E,T+,N,T,F

[ 风险声明 (欧洲) ]:
R1

[ 安全声明 (欧洲) ]:
S35-S45-S60-S61-S27-S16-S36/37-S24/25-S23-S53

[ 危险品运输编码 ]:
1354

[ RTECS号 ]:
DC3850000

[ 包装等级 ]:
II

[ 危险类别 ]:
1.1D

[ 海关编码 ]:
2904209090

1,3,5-三硝基苯合成路线

1,3,5-三硝基苯上下游产品

1,3,5-三硝基苯上游产品

1,3,5-三硝基苯下游产品

1,3,5-三硝基苯海关

[ 海关编码 ]: 2904209090

[ 中文概述 ]:
2904209090 其他仅含硝基或亚硝基的衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:5.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2904209090 derivatives containing only nitro or only nitroso groups。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

1,3,5-三硝基苯文献

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World J. Gastroenterol. 20(31) , 10876-85, (2014)

To investigate the beneficial effect of the combination of butyrate, Lactobacillus casei, and L-carnitine in a rat colitis model.Rats were divided into seven groups. Four groups received oral butyrate...

Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis.

Pharm. Biol. 53(3) , 429-36, (2015)

Tragopogon graminifolius DC. (Compositae) (TG) has been proposed as an efficacious remedy for gastrointestinal ulcers in Iranian traditional medicine.The present study evaluates the efficacy of TG on ...

Tumor-targeting and pH-sensitive lipoprotein-mimic nanocarrier for targeted intracellular delivery of paclitaxel.

Int. J. Pharm. 480(1-2) , 116-27, (2015)

In the present study, we constructed a tumor-targeting and pH-sensitive lipoprotein-mimic nanocarrier containing paclitaxel (FA-BSA-LC/DOPE-PTX), by adding 1,2-dioleoyl-sn-glycero-3-phosphoethanolamin...

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