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Neuropeptide FF trifluoroacetate salt

Neuropeptide FF trifluoroacetate salt用途

Neuropeptide FF (NPFF),是一种属于RF-酰胺类家族的八肽,与两种不同的 G 蛋白偶联受体 NPFF(1) 和 NPFF(2) 相互作用,在脑内具有多种生理功能,包括中枢心血管和神经内分泌调节。

Neuropeptide FF trifluoroacetate salt名称

[ CAS 号 ]:
99566-27-5

[ 中文名 ]:
神经肽-FF

[ 英文名 ]:
Neuropeptide FF Morphine Modulating Neuropeptide F-8-F-NH2

[英文别名 ]:

H-PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2
ninamide
NPFF
PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE AMIDE
F-8-F-NH2
PHE-LEU-PHE-GLN-PRO-GLN-ARG-PHE-NH2
MFCD00076704
F-8-F-NH2,NPFF,F-8-F-aMide
TC Mps1 12

Neuropeptide FF trifluoroacetate salt生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 心血管疾病

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Mankus JV, et al. Nonpeptide ligands of neuropeptide FF: current status and structural insights. Future Med Chem. 2012 Jun;4(9):1085-92.

[2]. Jhamandas JH, et al. Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol (Lausanne). 2013 Feb 7;4:8.

Neuropeptide FF trifluoroacetate salt物理化学性质

[ 密度 ]:
1.38 g/cm3

[ 分子式 ]:
C₅₄H₇₆N₁₄O₁₀

[ 分子量 ]:
1081.27

[ 精确质量 ]:
1080.59000

[ PSA ]:
412.10000

[ LogP ]:
4.54270

[ 折射率 ]:
1.656

[ 储存条件 ]:
−20°C

[ 水溶解性 ]:
Soluble to 0.50 mg/ml in water.

Neuropeptide FF trifluoroacetate salt安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

Neuropeptide FF trifluoroacetate salt文献

The anti-inflammatory potential of neuropeptide FF in vitro and in vivo.

Peptides 47 , 124-32, (2013)

Neuropeptide FF (NPFF) has many functions in regulating various biological processes. However, little attention has been focused on the anti-inflammatory effect of this peptide. In the present study, ...

Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.

Peptides 30(9) , 1683-8, (2009)

GPR103 is one of the orphan G protein-coupled receptors. Recently, an endogenous ligand for GPR103, 26RFa, was identified. Many 26RFa binding sites have been observed in various nuclei of the brain in...

Pressor and tachycardic responses to intrathecal administration of neuropeptide FF in anesthetized rats.

Peptides 31(4) , 683-8, (2010)

Neuropeptide FF (NPFF) belongs to a neuropeptide family including two precursors (pro-NPFF(A) and pro-NPFF(B)) and two receptors (NPFF(1) and NPFF(2)). NPFF and NPFF receptor mRNAs have been reported ...

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