CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
RC6311000
-
CHEMICAL NAME :
-
L-Norleucine, 6-diazo-N-(6-diazo-N-L-gamma-glutamyl-5-oxo-L-norleuc yl)-5-oxo-, sodium salt
-
CAS REGISTRY NUMBER :
-
55156-24-6
-
LAST UPDATED :
-
199509
-
DATA ITEMS CITED :
-
4
-
MOLECULAR FORMULA :
-
C17-H23-N7-O8.xNa
-
MOLECULAR WEIGHT :
-
614.40
-
WISWESSER LINE NOTATION :
-
QVYZ2VMY2V1UNN&VMYVQ2V1UNN &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
388 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
262 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - ataxia Gastrointestinal - hypermotility, diarrhea Liver - other changes
-
REFERENCE :
-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,3467,1974
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
271 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
REFERENCE :
-
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986 ** OTHER MULTIPLE DOSE TOXICITY DATA **
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
4300 ug/kg/5D-I
-
TOXIC EFFECTS :
-
Gastrointestinal - changes in structure or function of endocrine pancreas Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) Related to Chronic Data - death
-
REFERENCE :
-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 23,3467,1974
|