60407-53-6

• 常用中文名：alpha-(氨基甲基)-2,5-二甲氧基苄醇盐酸盐
• 常用英文名：alpha-(Aminomethyl)-2,5-dimethoxybenzyl alcohol hydrochloride
• CAS号：60407-53-6
• 分子式：C₁₀H₁₆ClNO₃
• 分子量：233.69200
• 发布时间：2018-12-17 01:02:28
• 更新时间：2024-01-10 15:21:10

名称

• 中文名: alpha-(氨基甲基)-2,5-二甲氧基苄醇盐酸盐
• 英文名: 2-amino-1-(2,5-dimethoxyphenyl)ethanol,hydrochloride
• 英文别名: 1-(2,5-dimethoxyphenyl)-2-aminoethanol hydrochloride; 2-Amino-1-(2,5-dimethoxy-phenyl)-aethanol,Hydrochlorid; 2-amino-1-(2,5-dimethoxy-phenyl)-ethanol,hydrochloride; 2-azanyl-1-(2,5-dimethoxyphenyl)ethanol hydrochloride

物化性质

• 沸点: 364.3ºC at 760 mmHg
• 熔点: 158.5ºC
• 分子式: C₁₀H₁₆ClNO₃
• 分子量: 233.69200
• 闪点: 174.1ºC
• 精确质量: 233.08200
• PSA: 64.71000
• LogP: 2.19820

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DN6825000 CHEMICAL NAME : Benzyl alcohol, alpha-aminomethyl-2,5-dimethoxy-, hydrochloride CAS REGISTRY NUMBER : 60407-53-6 LAST UPDATED : 199303 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C10-H15-N-O3.Cl-H MOLECULAR WEIGHT : 233.72 WISWESSER LINE NOTATION : Z1YQR BO1 EO1 &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1470 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,529,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 131 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity) Gastrointestinal - changes in structure or function of salivary glands REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,283,1948 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3770 ug/kg TOXIC EFFECTS : Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Behavioral - stiffness REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 21,529,1987

合成路线

83436-61-7 ~65% 60407-53-6

文献：Epifani, E.; Lapucci, A.; Macchia, B.; Macchia, F.; Tognetti, P.; et al. Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 254 - 259

1204-21-3 ~% 60407-53-6

文献：Journal of Medicinal Chemistry, , vol. 26, # 2 p. 254 - 259

83436-58-2 ~% 60407-53-6

文献：Journal of Medicinal Chemistry, , vol. 26, # 2 p. 254 - 259

141367-35-3 ~% 60407-53-6

文献：European Journal of Medicinal Chemistry, , vol. 32, # 11 p. 881 - 888

93-02-7 ~% 60407-53-6

文献：European Journal of Medicinal Chemistry, , vol. 32, # 11 p. 881 - 888