110545-67-0

• 常用中文名：4-溴-3-甲氧基噻酚-2-羧酸甲酯
• 常用英文名：methyl 4-bromo-3-methoxythiophene-2-carboxylate
• CAS号：110545-67-0
• 分子式：C₁₁H₁₉NO₆
• 分子量：261.272
• 发布时间：2018-12-15 23:34:12
• 更新时间：2024-01-21 14:26:36

名称

• 中文名: 4-溴-3-甲氧基噻酚-2-羧酸甲酯
• 英文名: methyl 4-bromo-3-methoxythiophene-2-carboxylate
• 英文别名: methyl 4-bromo-3-(methyloxy)-2-thiophenecarboxylate; 2-Thiophenecarboxylicacid,4-bromo-3-methoxy-,methyl ester; 4-Bromo-3-Methoxy-2-Thiophenecarboxylic Acid Methyl Ester; methyl-3-methoxy-4-bromo-2-thiophenecarboxylate; (2R)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)hexanedioic acid; (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanedioic acid; 4-bromo-3-metoxy-thiophene-2-carboxylic acid methyl ester; methyl 4-bromo-3-methoxy-2-thiophenecarboxylate; Hexanedioic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (2R)-

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 462.1±35.0 °C at 760 mmHg
• 熔点: 73ºC
• 分子式: C₁₁H₁₉NO₆
• 分子量: 261.272
• 闪点: 233.3±25.9 °C
• 精确质量: 261.121246
• PSA: 63.77000
• LogP: 1.24
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.491

MSDS

Name: Methyl 4-bromo-3-methoxythiophene-2-carboxylate 97% Material Safety Data Sheet Synonym: CAS: 110545-67-0 Section 1 - Chemical Product MSDS Name:Methyl 4-bromo-3-methoxythiophene-2-carboxylate 97% Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 110545-67-0 Methyl 4-bromo-3-methoxythiophene-2-ca 97% unlisted Hazard Symbols: XI Risk Phrases: 36/37/38 Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Irritating to eyes, respiratory system and skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: Causes respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 110545-67-0: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: white Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 75 - 77 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C7H7BrO3S Molecular Weight: 251 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Strong oxidizing agents, acids. Hazardous Decomposition Products: Carbon monoxide, oxides of sulfur, carbon dioxide, hydrogen bromide, bromine. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 110545-67-0 unlisted. LD50/LC50: Not available. Carcinogenicity: Methyl 4-bromo-3-methoxythiophene-2-carboxylate - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: XI Risk Phrases: R 36/37/38 Irritating to eyes, respiratory system and skin. Safety Phrases: S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S 37/39 Wear suitable gloves and eye/face protection. WGK (Water Danger/Protection) CAS# 110545-67-0: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 110545-67-0 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 110545-67-0 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 危害码 (欧洲): Xi
• 风险声明 (欧洲): R36/37/38
• 安全声明 (欧洲): S26-S37/39
• 海关编码: 2934999090

合成路线

95201-93-7 74-88-4 ~99% 110545-67-0

文献：WO2004/33440 A1, ; Page 185 ; WO 2004/033440 A1

95201-93-7 77-78-1 ~75% 110545-67-0

文献：European Journal of Medicinal Chemistry, , vol. 22, # 3 p. 251 - 254

5118-06-9 ~% 110545-67-0

文献：Tetrahedron Letters, , vol. 52, # 12 p. 1288 - 1291

上下游产品

上游产品  4
95201-93-7 74-88-4 77-78-1 5118-06-9
下游产品  0

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%