10039-56-2

• 常用中文名：次亚磷酸钠 一水合物
• 常用英文名：Sodium hypophosphite monohydrate
• CAS号：10039-56-2
• 分子式：H₂NaO₃P
• 分子量：103.97800
• 相关类别： 无机化工 无机盐 磷化物、金属的磷酸、偏磷酸、次磷酸和焦磷酸盐
• 发布时间：2018-06-28 18:20:22
• 更新时间：2024-01-02 11:31:01
• 【用途一】
  用作分析试剂，也用于临床检验

名称

• 中文名: 次亚磷酸钠
• 英文名: Sodium hypophosphite monohydrate
• 中文别名: 次磷酸钠单水; 一水次磷酸钠
• 英文别名: Sodiumhypophosphitemonohydrate; EINECS 231-669-9; Fosfornan sodny [Czech]; MFCD00149207; Sodium Hypophosphite Monohydrate

物化性质

• 密度: 0.8 g/cm3 (20ºC)
• 熔点: 90°C
• 分子式: H₂NaO₃P
• 分子量: 103.97800
• 精确质量: 103.96400
• PSA: 83.50000
• LogP: 0.55930
• 外观性状: 无气味的白色晶体在室温中
• 储存条件: 室温
• 稳定性:

  具有强还原性，与氯酸盐和氧化剂接触能爆炸。

• 水溶解性: 1000 g/L (20 ºC)
• 分子结构:

  1、摩尔折射率：无可用的

  2、摩尔体积（cm³/mol）：无可用的

  3、等张比容（90.2K）：无可用的

  4、表面张力（dyne/cm）：无可用的

  5、介电常数：无可用的

  6、极化率（10^-24cm³）：无可用的

  7、单一同位素质量：103.963925 Da

  8、标称质量：104 Da

  9、平均质量：103.9776 Da

• 计算化学:

  1、 疏水参数计算参考值（XlogP）：-1.2

  2、 氢键供体数量：0

  3、 氢键受体数量：2

  4、 可旋转化学键数量：0

  5、 拓扑分子极性表面积（TPSA）：40.1.

  6、 重原子数量：3

  7、 表面电荷：-1

  8、 复杂度：7.5

  9、 同位素原子数量：0

  10、 确定原子立构中心数量：0

  11、 不确定原子立构中心数量：0

  12、 确定化学键立构中心数量：0

  13、 不确定化学键立构中心数量：0

  14、 共价键单元数量：1

• 更多:

  1. 性状：白色无气味粉末。

  2. 密度（g/mL,25℃）：1.86

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：248

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,20ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：溶于水1000 g/L (20 ºC)。溶液醇和甘油，微溶于无水乙醇，不溶于醚。

MSDS

Name: Sodium Hypophosphite Monohydrate 99% Material Safety Data Sheet Synonym: Phosphinic Acid Sodium Salt Monohydrate; Sodium Hypophosphite Monohydrat CAS: 10039-56-2 Section 1 - Chemical Product MSDS Name:Sodium Hypophosphite Monohydrate 99% Material Safety Data Sheet Synonym:Phosphinic Acid Sodium Salt Monohydrate; Sodium Hypophosphite Monohydrat Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 10039-56-2 Sodium Hypophosphite Monohydrate >98 unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW The toxicological properties of this material have not been fully investigated. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated. Chronic: No information found. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse. Ingestion: Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Notes to Physician: Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. Combustion generates toxic fumes. Decomposes generating flammable and toxic phosphine gas. Extinguishing Media: Use agent most appropriate to extinguish fire. Use water spray, dry chemical, carbon dioxide, or appropriate foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Clean up spills immediately, observing precautions in the Protective Equipment section. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation. Section 7 - HANDLING and STORAGE Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Storage: Store in a cool, dry, well-ventilated area away from incompatible substances. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin. Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Appearance: white Odor: odorless pH: Not available. Vapor Pressure: Negligible Viscosity: Not available. Boiling Point: Decomposes Freezing/Melting Point: 90 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: N/A Explosion Limits, upper: N/A Decomposition Temperature: >90 C Solubility in water: Soluble in water Specific Gravity/Density: 0.8 Molecular Formula: NaH2PO2.H20 Molecular Weight: 87.9764 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Stable. However, may decompose if heated. Conditions to Avoid: High temperatures, incompatible materials, dust generation, moisture. Incompatibilities with Other Materials: Strong oxiziders, moisture. Hazardous Decomposition Products: Phosphine, irritating and toxic fumes and gases, toxic fumes of sodium oxide, hydrogen gas. Hazardous Polymerization: Has not been reported. Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 10039-56-2: SZ5640000 LD50/LC50: CAS# 10039-56-2: Oral, rat: LD50 = 7640 mg/kg. Carcinogenicity: Sodium Hypophosphite Monohydrate - Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA. Other: See actual entry in RTECS for complete information. Section 12 - ECOLOGICAL INFORMATION Other No information available. Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: IMO Shipping Name: Not regulated. Hazard Class: UN Number: Packing Group: RID/ADR Shipping Name: Not regulated. Dangerous Goods Code: UN Number: Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 10039-56-2: 2 United Kingdom Occupational Exposure Limits Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 10039-56-2 is not listed on Canada's Ingredient Disclosure List. Exposure Limits US FEDERAL TSCA CAS# 10039-56-2 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

毒理学数据: 1、急性毒性：大鼠经口LD50：7640 mg/kg 生态学数据: 通常对水体是稍微有害的，不要将未稀释或大量产品接触地下水，水道或污水系统，未经政府许可勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : SZ5640000 CHEMICAL NAME : Phosphinic acid, sodium salt, monohydrate CAS REGISTRY NUMBER : 10039-56-2 LAST UPDATED : 199404 DATA ITEMS CITED : 2 MOLECULAR FORMULA : H2-O2-P.Na.H2-O HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7640 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972 Volume(issue)/page/year: -,16,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T1724 No. of Facilities: 8 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 23 (estimated)

安全

• 个人防护装备: Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
• 安全声明 (欧洲): S22-S24/25
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3
• RTECS号: SZ5640000
• 海关编码: 2835100000

合成路线

12185-10-3 ~% 10039-56-2

文献：Journal of the American Chemical Society, , vol. 57, p. 300 - 302 P: MVol.B, 3.4.1.5, page 276 - 281

10049-21-5 ~% 10039-56-2

文献：Journal of Inorganic and Nuclear Chemistry, , vol. 15, p. 386 - 387

10039-56-2 ~% 10039-56-2 7732-18-5

文献：Justus Liebigs Annalen der Chemie, , vol. 550, p. 1 - 31

上下游产品

上游产品  3
12185-10-3 10049-21-5 10039-56-2
下游产品  10
13598-36-2 7664-38-2 7803-51-2 6303-21-5
14000-31-8 124-43-6 7732-18-5 56-81-5
7647-14-5 10049-21-5

制备

1.将黄磷 （ 或白磷） 、过量的氢氧化钙水溶液于98℃下进行反应：

反应中生的磷化氢引出后用10%的硫酸铜溶液吸收 （ 要注意安全！ ） 。反应结束后，冷却，通入二氧化碳至溶液ph值为7.5～8.0，沉淀出过量氢氧化钙。滤出沉淀并用水洗涤数次，洗液并入滤液，然后分次少量加入20%的碳酸钠溶液至溶液对酚酞呈弱碱性：

过滤，滤液真空蒸发浓缩至密度为1.16时，重新过滤。滤液第二次蒸发浓缩至出现结晶薄膜，冷却结晶，甩干后，于80～95℃干燥，可制得次磷酸钠。
母液可回收利用。

海关

海关编码	2835100000