194491-44-6

• 常用中文名：(5-(噻吩-2-基)异恶唑-3-基)甲醇
• 常用英文名：[5-(2-THIENYL)-3-ISOXAZOLYL]METHANOL
• CAS号：194491-44-6
• 分子式：C₈H₇NO₂S
• 分子量：181.21
• 相关类别： 信号通路 抗感染 细菌
• 发布时间：2018-12-22 09:55:57
• 更新时间：2024-01-10 14:45:28
• [5-(2-Thienyl)-3-isoxazolyl]methanol (Compound D) 是一种 AgrA-DNA 结合抑制剂。[5-(2-Thienyl)-3-isoxazolyl]methanol 可用于金黄色葡萄球菌感染研究。

名称

• 中文名: (5-(2-噻吩基)异噁唑)甲醇
• 英文名: (5-thiophen-2-yl-1,2-oxazol-3-yl)methanol
• 英文别名: 4b0j; F2135-0540; 3MQ

物化性质

• 密度: 1.351g/cm3
• 沸点: 366ºC at 760mmHg
• 熔点: 54-55ºC
• 分子式: C₈H₇NO₂S
• 分子量: 181.21
• 精确质量: 181.02000
• PSA: 74.50000
• LogP: 1.89540
• 蒸汽压: 5.3E-06mmHg at 25°C
• 折射率: 1.603
• 储存条件: 2-8°C， 避光干燥

生物活性

• 描述: [5-(2-Thienyl)-3-isoxazolyl]methanol (Compound D) 是一种 AgrA-DNA 结合抑制剂。[5-(2-Thienyl)-3-isoxazolyl]methanol 可用于金黄色葡萄球菌感染研究。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Leonard PG, et al. Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding. Biochemistry. 2012 Dec 18;51(50):10035-43.

MSDS

Name: [5-(2-Thienyl)-3-isoxazolyl]methanol tech Material Safety Data Sheet Synonym: CAS: 194491-44-6 Section 1 - Chemical Product MSDS Name:[5-(2-Thienyl)-3-isoxazolyl]methanol tech Material Safety Data Sheet Synonym: Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS CAS# Chemical Name content EINECS# 194491-44-6 [5-(2-Thienyl)-3-isoxazolyl]methanol unlisted Hazard Symbols: None Listed. Risk Phrases: None Listed. Section 3 - HAZARDS IDENTIFICATION EMERGENCY OVERVIEW Not available. Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Chronic: Not available. Section 4 - FIRST AID MEASURES Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water. Inhalation: Remove from exposure and move to fresh air immediately. Notes to Physician: Treat symptomatically and supportively. Section 5 - FIRE FIGHTING MEASURES General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. Section 6 - ACCIDENTAL RELEASE MEASURES General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Section 7 - HANDLING and STORAGE Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Storage: Store in a cool, dry place. Store in a tightly closed container. Store under nitrogen. Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION Engineering Controls: Use adequate ventilation to keep airborne concentrations low. Exposure Limits CAS# 194491-44-6: Personal Protective Equipment Eyes: Not available. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. Section 9 - PHYSICAL AND CHEMICAL PROPERTIES Physical State: Solid Color: brown Odor: Not available. pH: Not available. Vapor Pressure: Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point: 54 - 55 deg C Autoignition Temperature: Not available. Flash Point: Not available. Explosion Limits, lower: Not available. Explosion Limits, upper: Not available. Decomposition Temperature: Solubility in water: Specific Gravity/Density: Molecular Formula: C8H7NO2S Molecular Weight: 181.21 Section 10 - STABILITY AND REACTIVITY Chemical Stability: Not available. Conditions to Avoid: Incompatible materials. Incompatibilities with Other Materials: Oxidizing agents, acids, acid chlorides, halogenated agents, halogens. Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide. Hazardous Polymerization: Has not been reported Section 11 - TOXICOLOGICAL INFORMATION RTECS#: CAS# 194491-44-6 unlisted. LD50/LC50: Not available. Carcinogenicity: [5-(2-Thienyl)-3-isoxazolyl]methanol - Not listed by ACGIH, IARC, or NTP. Section 12 - ECOLOGICAL INFORMATION Section 13 - DISPOSAL CONSIDERATIONS Dispose of in a manner consistent with federal, state, and local regulations. Section 14 - TRANSPORT INFORMATION IATA No information available. IMO No information available. RID/ADR No information available. Section 15 - REGULATORY INFORMATION European/International Regulations European Labeling in Accordance with EC Directives Hazard Symbols: Not available. Risk Phrases: Safety Phrases: S 24/25 Avoid contact with skin and eyes. WGK (Water Danger/Protection) CAS# 194491-44-6: No information available. Canada None of the chemicals in this product are listed on the DSL/NDSL list. CAS# 194491-44-6 is not listed on Canada's Ingredient Disclosure List. US FEDERAL TSCA CAS# 194491-44-6 is not listed on the TSCA inventory. It is for research and development use only. SECTION 16 - ADDITIONAL INFORMATION N/A

安全

• 安全声明 (欧洲): S24/25
• 海关编码: 2934999090

上下游产品

上游产品  4
90924-54-2 88-15-3 5370-25-2 36983-36-5
下游产品  1
465514-11-8

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%