64058-48-6

• 常用中文名：硫酸大观霉素
• 常用英文名：Spectinomycin sulfate tetrahydrate
• CAS号：64058-48-6
• 分子式：C₁₄H₃₄N₂O₁₄S
• 分子量：448.443
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-05-21 08:00:00
• 更新时间：2024-01-06 12:53:23
• 对革兰氏阳性菌及阴性菌均有较强的抑制能力,对金黄色葡萄球菌、溶血性链球菌、肺炎双球菌、普通变形杆菌、肺炎杆菌等以及支原体微浆菌和某些孤菌均有效。

名称

• 中文名: 硫酸大观霉素(四水)
• 英文名: Spectinomycin sulfate tetrahydrate
• 中文别名: 硫酸大观霉素; 硫酸壮观霉素四水化合物
• 英文别名: SPECTINOMYCIN SULPHATE; Trobicin sulfate; (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-Trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one sulfate hydrate (1:1:1); SpectinoMycin sulfate tetrahydrate CGMP/FDA; SPECTINOMYCINHCL; Actinospectacin,tetrahydrate,sulfate; Spectinomycin sulfate; 4H-Pyrano[2,3-b][1,4]benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-, sulfate, hydrate (1:1:1) (salt); Spectinomycin,tetrahydrate,sulfate

物化性质

• 沸点: 583.1ºC at 760 mmHg
• 熔点: ~185° (dec)
• 分子式: C₁₄H₃₄N₂O₁₄S
• 分子量: 448.443
• 精确质量: 448.136292
• PSA: 229.18000
• 外观性状: 白色固体
• 储存条件: 20°C，惰性气体

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WG7430000 CHEMICAL NAME : Spectinomycin, sulfate, tetrahydrate CAS REGISTRY NUMBER : 64058-48-6 LAST UPDATED : 199706 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C14-H24-N2-O7.O4-S.4H2-O MOLECULAR WEIGHT : 500.54 WISWESSER LINE NOTATION : T C666 BO DO GV IOTJ E1 HQ KM1 LQ MM1 NQ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3867 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1022 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : UPJOH* "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." (Kalamazoo, MI 49001) Volume(issue)/page/year: 2(6),-,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2808 No. of Facilities: 403 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4029 (estimated) No. of Female Employees: 2015 (estimated)

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危害码 (欧洲): Xn
• 危险品运输编码: NONH for all modes of transport