36457-20-2

• 常用中文名：尼泊金丁酯钠盐
• 常用英文名：Sodium 4-(butoxycarbonyl)phenolate
• CAS号：36457-20-2
• 分子式：C₁₁H₁₃NaO₃
• 分子量：216.209
• 相关类别： 有机原料 有机金属盐
• 发布时间：2018-10-02 13:04:47
• 更新时间：2024-01-02 12:36:20
• 【用途一】
  广泛用于医药、食品、纺织工业的防腐以及其他领域如化妆品、饲料、日用工业品的防腐

名称

• 中文名: 对羟基苯甲酸丁酯钠
• 英文名: Butylparaben Sodium Salt
• 英文别名: Sodium 4-(butoxycarbonyl)phenolate; EINECS 253-049-7; MFCD01661516; sodium,4-butoxycarbonylphenolate; Benzoic acid, 4-hydroxy-, butyl ester, sodium salt (1:1)

物化性质

• 密度: 1.13g/mL
• 沸点: 309.2ºC at 760 mmHg
• 分子式: C₁₁H₁₃NaO₃
• 分子量: 216.209
• 闪点: 129.2ºC
• 精确质量: 216.076233
• PSA: 49.36000
• LogP: 2.78730
• 外观性状: 白色结晶粉末
• 储存条件: 室温，干燥

生物活性

• 描述: Butylparaben sodium 可破坏激素控制和/或 RNA 和蛋白质合成来强烈影响睾丸精子发生的后期。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 其他
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Shinshi Oishi, et al. Effects of butyl paraben on the male reproductive system in mice. Arch Toxicol. 2002 Jul;76(7):423-9.

  [2]. Bae JS, et al. Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats. Arch Toxicol. 2021 Jun;95(6):2037-2050.

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Butylparaben sodium salt Synonyms:4-Hydroxybenzoic butyl ester sodium slat Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:Butylparaben sodium salt CAS number:36457-20-2 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C11H13O3.Na Molecular weight:216.2 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DH2040000 CHEMICAL NAME : Benzoic acid, p-hydroxy-, butyl ester, sodium salt CAS REGISTRY NUMBER : 36457-20-2 LAST UPDATED : 199107 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C11-H13-O3.Na MOLECULAR WEIGHT : 216.23 WISWESSER LINE NOTATION : QR DVO4 &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 950 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 230 mg/kg TOXIC EFFECTS : Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - somnolence (general depressed activity) Behavioral - ataxia REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956

安全

• 危险品运输编码: 3077.0
• 危险类别: 9.0
• 海关编码: 2918990090

海关

海关编码	2918990090
中文概述	2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
申报要素	品名, 成分含量, 用途
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%