405-22-1

• 常用中文名：尼屈昔腙
• 常用英文名：nidroxyzone
• CAS号：405-22-1
• 分子式：C₈H₁₀N₄O₅
• 分子量：242.18900
• 相关类别： 化学试剂 有机试剂 腙
• 发布时间：2018-05-28 08:00:00
• 更新时间：2024-01-18 18:25:42

名称

• 中文名: 尼屈昔腙
• 英文名: Hydrazinecarboxamide,1-(2-hydroxyethyl)-2-[(5-nitro-2-furanyl)methylene]
• 英文别名: Furadroxyl; Fradroxyl; 5-Nitro-furaldehyd-2-<(2-hydroxy-ethyl)-semicarbazon>; nidroxyzone; 5-Nitro-2-furaldehyde 2-(2-hydroxyethyl)semicarbazone; 5-nitro-furfural-[2-(2-hydroxy-ethyl)-semicarbazone]; 5-Nitro-furfural-[2-(2-hydroxy-aethyl)-semicarbazon]

物化性质

• 密度: 1.59g/cm3
• 沸点: 453.2ºC at 760mmHg
• 熔点: 214-216° (dec)
• 分子式: C₈H₁₀N₄O₅
• 分子量: 242.18900
• 闪点: 227.9ºC
• 精确质量: 242.06500
• PSA: 137.88000
• LogP: 1.11820
• 蒸汽压: 5.29E-09mmHg at 25°C
• 折射率: 1.639

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : LT7400000 CHEMICAL NAME : 2-Furaldehyde, 5-nitro-, 2-(2-hydroxyethyl)semicarbazone CAS REGISTRY NUMBER : 405-22-1 BEILSTEIN REFERENCE NO. : 0269535 LAST UPDATED : 199612 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C8-H10-N4-O5 MOLECULAR WEIGHT : 242.22 WISWESSER LINE NOTATION : T50J BNW E1UNNVZ2Q HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,313,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 300 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC) V.1-12, 1951-62. For publisher information, see CLMEA3. Volume(issue)/page/year: 3,429,1953 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1800 mg/kg SEX/DURATION : male 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - other effects on male REFERENCE : ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 112,367,1952 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1800 mg/kg SEX/DURATION : male 30 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 56,727,1955 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 3360 mg/kg SEX/DURATION : female 14 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 5520 mg/kg SEX/DURATION : female 23 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - menstrual cycle changes or disorders REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1200 mg/kg SEX/DURATION : male 10 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2520 mg/kg SEX/DURATION : male 21 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 69,331,1961

安全

• 海关编码: 2934999090

合成路线

698-63-5 109-84-2 ~% 405-22-1

文献：Eaton Labor. Inc. Patent: US2416234 , 1945 ; Full Text Show Details Kashiwara; Imoto Kogyo Kagaku Zasshi, 1952 , vol. 55, p. 593 Chem.Abstr., 1955 , p. 2309

上下游产品

上游产品  2
698-63-5 109-84-2
下游产品  2
67-45-8 5407-76-1

海关

海关编码	2934999090
中文概述	2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%