7227-92-1

• 常用中文名：1-Triazene,3,3-dimethyl-1-(4-nitrophenyl)-
• 常用英文名：1-Triazene,3,3-dimethyl-1-(4-nitrophenyl)-
• CAS号：7227-92-1
• 分子式：C₈H₁₀N₄O₂
• 分子量：194.19100
• 发布时间：2017-06-04 21:59:00
• 更新时间：2024-01-09 22:07:02

名称

• 英文名: N-methyl-N-[(4-nitrophenyl)diazenyl]methanamine
• 英文别名: 1-(p-nitrophenyl)-3,3-dimethyltriazene; 1-(4-Nitrophenyl)-3,3-dimethyltriazene; Triazene,3,3-dimethyl-1-(p-nitrophenyl); 3,3-dimethyl-1-(p-nitrophenyl)-1-triazene; 1-(p-nitrophenyl)-3,3-dimethyl-1-triazene; 1-p-Nitrofenyl-3,3-dimethyltriazen; 3,3-dimethyl-1-(4-nitrophenyl)triazene; 3,3-Dimethyl-1-(p-nitrophenyl)triazene; 3,3-Dimethyl-1-(4-nitro-phenyl)-triazen; 1-(p-Nitrophenyl)-3,3-dimethyltriazine; 3,3-Dimethyl-p-nitrophenyltriazene

物化性质

• 分子式: C₈H₁₀N₄O₂
• 分子量: 194.19100
• 精确质量: 194.08000
• PSA: 73.78000
• LogP: 2.67830

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XY1450000 CHEMICAL NAME : Triazene, 3,3-dimethyl-1-(p-nitrophenyl)- CAS REGISTRY NUMBER : 7227-92-1 LAST UPDATED : 199410 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C8-H10-N4-O2 MOLECULAR WEIGHT : 194.22 WISWESSER LINE NOTATION : WNR DNUNN1&1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1664 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi Gastrointestinal - ulceration or bleeding from stomach Liver - other changes TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 350 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3250 mg/kg/72W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Brain and Coverings - tumors Peripheral Nerve and Sensation - peripheral nerve tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 330 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Peripheral Nerve and Sensation - peripheral nerve tumors MUTATION DATA TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 1 umol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 190,183,1987

合成路线

124-40-3 ~% 7227-92-1

文献：Elks; Hey Journal of the Chemical Society, 1943 , p. 441,443

456-27-9 124-40-3 ~% 7227-92-1

文献：Kaupp, Gerd; Herrmann, Andreas Advanced Synthesis and Catalysis, 1997 , vol. 339, # 3 p. 256 - 260

100-05-0 124-40-3 ~% 7227-92-1

文献：Hooper, Donald L.; Vaughan, Keith Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1981 , p. 1161 - 1165

100-01-6 124-40-3 ~74% 7227-92-1

文献：Manolov, Ilia; Machulla; Momekov Pharmazie, 2006 , vol. 61, # 6 p. 511 - 516

100-01-6 ~% 7227-92-1

文献：Kaupp, Gerd; Herrmann, Andreas Advanced Synthesis and Catalysis, 1997 , vol. 339, # 3 p. 256 - 260

456-27-9 68-12-2 ~% 7227-92-1

文献：Markgraf, J. Hodge; Chang, Raymond; Cort, John R.; Durant Jr., Joseph L.; Finkelstein, Manuel; Gross, Andrew W.; Lavyne, Michael H.; Moore, W. Michael; Petersen, Raymond C.; Ross, Sidney D. Tetrahedron, 1997 , vol. 53, # 29 p. 10009 - 10018

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