CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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CG1000000
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CHEMICAL NAME :
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Arsenic acid, lead salt
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CAS REGISTRY NUMBER :
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7645-25-2
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LAST UPDATED :
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199806
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DATA ITEMS CITED :
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33
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MOLECULAR FORMULA :
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As-H3-O4.xPb
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MOLECULAR WEIGHT :
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1592.28
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WISWESSER LINE NOTATION :
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PB AS-O-Q3
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Human - man
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DOSE/DURATION :
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1428 mg/kg
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TOXIC EFFECTS :
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Liver - hepatitis (hepatocellular necrosis), diffuse Skin and Appendages - dermatitis, other (after systemic exposure) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other transferases
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REFERENCE :
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ANZJB8 Australian and New Zealand Journal of Medicine. (Modern Medicine of Australia Pty., Ltd., 100 Pacific Highway, North Sydney, 2060, Australia) V.1- 1971- Volume(issue)/page/year: 19,730,1989
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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100 mg/kg
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Nutritional and Gross Metabolic - dehydration
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REFERENCE :
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AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74. Volume(issue)/page/year: 15,122,1951
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1 gm/kg
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REFERENCE :
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JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 93,407,1948 *** REVIEWS *** ACGIH TLV-TWA 0.15 mg(Pb)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: As,-,1977 TOXICOLOGY REVIEW ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 13,36,1977 TOXICOLOGY REVIEW 85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77 Volume(issue)/page/year: Pb,255,1972 TOXICOLOGY REVIEW ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 16,139,1978 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Fed Cont):8H TWA 0.15 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 OSHA-cancer hazard CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1018,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.05 mg(Pb)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-AUSTRIA:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-BELGIUM:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-FINLAND:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-FRANCE:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-HUNGARY:STEL 0.04 mg(Pb)/m3;Carcinogen JAN 1993 OEL-THE PHILIPPINES:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL-RUSSIA:STEL 0.005 ppm (0.01 mg(Pb)/m3) JAN 1993 OEL-SWEDEN:TWA 0.05 mg(Pb)/m3 (resp. dust) JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Pb)/m3 (total dust) JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Pb)/m3 JAN 1993 OEL-THAILAND:TWA 0.2 mg(Pb)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Pb)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.15 mg(Pb)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO ARSENIC, INORGANIC-air:CA CL 0.002 mg(As)/m3/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO LEAD, INORGANIC-air:10H TWA <0.1 mg(Pb)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992
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