77732-09-3

• 常用中文名：恶霜灵
• 常用英文名：Oxadixyl
• CAS号：77732-09-3
• 分子式：C₁₄H₁₈N₂O₄
• 分子量：278.30400
• 相关类别： 化学农药原药 杀菌剂 唑类杀菌剂
• 发布时间：2018-06-08 10:56:53
• 更新时间：2024-01-08 20:19:28
• 【用途一】
  本品具有保护和治疗作用的内吸性杀菌剂，持效期长，对霜霉目病原菌有良好的活性。以250mg/L使用，持效期9～10d，治疗作用3d以上；以500mg/L防治葡萄霜霉病，持效期16d以上。本药剂大量用于与其他杀菌剂制成各种混剂使用，可取得更高的防效。

名称

• 中文名: 噁霜灵
• 英文名: oxadixyl
• 中文别名: 噁酰胺; 杀毒矾; 恶霜灵; 2-甲氧基-N-(2-氧代-1,3-恶唑烷-3-基)乙酰-2',6'-二甲基替苯胺; 恶唑烷酮
• 英文别名: Sandofan; MFCD00145052; OXADIXYL; Acetamide,N-(2,6-dimethylphenyl)-2-methoxy-N-(2-oxo-3-oxazolidinyl); SAN 371; Recoil; Oxadixyl [BSI:ISO]; N-(2,6-dimethylphenyl)-2-methoxy-N-(2-oxo-1,3-oxazolidin-3-yl)acetamide; SAN 371F; Wakil; N-(2,6-dimethylphenyl)-2-methoxy-N-(2-oxo-3-oxazolidinyl)acetamide; 2-methoxy-N-(2-oxo-1,3-oxazolidin-3-yl)acet-2’,6’-xylidide; Ripost

物化性质

• 密度: 1.265 g/cm3
• 沸点: 368.5ºC at 760 mmHg
• 熔点: 104-105ºC
• 分子式: C₁₄H₁₈N₂O₄
• 分子量: 278.30400
• 闪点: 176.6ºC
• 精确质量: 278.12700
• PSA: 59.08000
• LogP: 1.58790
• 折射率: 1.585
• 储存条件:

  存放在密封容器内，并放在阴凉，干燥处。

• 稳定性:

  远离氧化物。对兔眼睛和皮肤无刺激性，对豚鼠皮肤无过敏性。

• 水溶解性: 3.4 mg/L at 25 ºC
• 分子结构:

  1、 摩尔折射率：73.75

  2、 摩尔体积（cm³/mol）：219.8

  3、 等张比容(90.2K)：594.7

  4、 表面张力(dyne/cm)：53.5

  5、 极化率(10-24cm³)：29.24

• 计算化学:

  1.疏水参数计算参考值（XlogP）:1.8

  2.氢键供体数量:0

  3.氢键受体数量:4

  4.可旋转化学键数量:3

  5.互变异构体数量:无

  6.拓扑分子极性表面积59.1

  7.重原子数量:20

  8.表面电荷:0

  9.复杂度:364

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

• 更多:

  1. 性状：白色结晶体。

  2. 密度（g/mL,25/4℃）：1.279

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：104～105

  5. 沸点（ºC,常压）：369

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：＞100

  9. 比旋光度（º）：未确定

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：3.3×10^-6

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：微溶于水。

毒性和生态

毒理学数据: 大鼠急性经口LD50 1860 ~ 3380mg/kg，小鼠急性经口LD50 1860～2150mg /kg;大鼠急性经皮LD50> 2000mg /kg;大鼠急性吸入LC50 > 6mg/I_空气(6h);鲤鱼LC50 >300mg/L( 96h )，虹蝉鱼LC50 > 320mg/L ( 96h ) ,野鸡急性经口LD50 >251 Omg /kg ,蜜蜂急性按触LD50 100~200/只。 生态学数据: 通常对水是不危害的，若无政府许可，勿将材料排入周围环境。 CHEMICAL IDENTIFICATION RTECS NUMBER : AB8131400 CHEMICAL NAME : Acetamide, N-(2,6-dimethylphenyl)-2-methoxy-N-(2-oxo-3-oxazolidi nyl)- CAS REGISTRY NUMBER : 77732-09-3 LAST UPDATED : 199701 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C14-H18-N2-O4 MOLECULAR WEIGHT : 278.34 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1860 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,635,1991 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >6 gm/m3/6H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A794,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947- Volume(issue)/page/year: 39(232),8,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 278 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 611 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 693 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 184 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 560 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988 TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >6 gm/m3 TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C226,1991 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A794,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : >2510 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,635,1991 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5460 mg/kg/13W-C TOXIC EFFECTS : Liver - changes in liver weight REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 43800 mg/kg/2Y-C TOXIC EFFECTS : Liver - other changes Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 32592 mg/kg/97W-C TOXIC EFFECTS : Liver - changes in liver weight REFERENCE : NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 13,639,1988

安全

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R22
• 危险品运输编码: NONH for all modes of transport
• RTECS号: AB8131400

制备

2，6-二甲基苯肼的制备
2，6-二甲基苯胺经重氮化、还原制得2，6-二甲基苯肼。
3-（2，6-二甲苯氨基）噁唑烷-2-酮的制备 2，6-二甲基苯肼与氯代甲酸溴丙酯进行环合缩合制得。
噁霜灵的合成 3-（2，6-二甲苯氨基）噁唑烷-2-酮与2-甲氧基乙酰氯作用制得。