106900-12-3

• 常用中文名：氧洛哌丁胺
• 常用英文名：Loperamide
• CAS号：106900-12-3
• 分子式：C₂₉H₃₃ClN₂O₃
• 分子量：493.03700
• 相关类别： 分析化学 标准品 药典标准品和杂志标准品
• 发布时间：2018-03-31 08:00:00
• 更新时间：2024-01-02 20:14:52
• Loperamide oxide is a prodrug of the effective antidiarrheal loperamide.

名称

• 中文名: 氧洛哌丁胺
• 英文名: 4-[4-(4-chlorophenyl)-4-hydroxy-1-oxidopiperidin-1-ium-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide
• 英文别名: Loperamide N-oxide; Loperamide oxide; trans-N-Oxide of loperamide; Arestal

物化性质

• 分子式: C₂₉H₃₃ClN₂O₃
• 分子量: 493.03700
• 精确质量: 492.21800
• PSA: 69.97000
• LogP: 5.05940
• 水溶解性: Practically insoluble in water, freely soluble in alcohol and in methylene chloride.

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : TM4960200 CHEMICAL NAME : 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha -diphenyl-, 1-oxide, (E)- CAS REGISTRY NUMBER : 106900-12-3 LAST UPDATED : 198910 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C29-H33-Cl-N2-O3 MOLECULAR WEIGHT : 493.09 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 172 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 28300 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 8,279,1986

安全

• 危险品运输编码: UN 2811 6.1 / PGIII
• RTECS号: TM4960200