6159-44-0

• 常用中文名：乙酸双氧铀
• 常用英文名：URANYL ACETATE DIHYDRATE
• CAS号：6159-44-0
• 分子式：C₄H₁₀O₈U
• 分子量：424.14600
• 发布时间：2018-03-12 08:00:00
• 更新时间：2024-01-04 18:12:13

• 临床检验中用于血钠测定。用作细菌氧化过程活化剂。
  

名称

• 中文名: 乙酸双氧铀
• 英文名: Uranyl acetate dihydrate
• 中文别名: 醋铀酰
• 英文别名: uranyl acetate dihydrate; EINECS 208-767-5

物化性质

• 分子式: C₄H₁₀O₈U
• 分子量: 424.14600
• 精确质量: 424.08800
• PSA: 132.86000
• 稳定性:

  有放射性，与皮肤接触或吞入时极毒，具有蓄积性危害。

• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:4

  3.氢键受体数量:8

  4.可旋转化学键数量:0

  5.互变异构体数量:3

  6.拓扑分子极性表面积111

  7.重原子数量:13

  8.表面电荷:0

  9.复杂度:129

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:5

• 更多:

  1.性状：黄色结晶性粉末。

  2. 相对密度：2.893

  3.溶解性：。溶于水，易溶于乙酸水溶液，微溶于乙醇。

MSDS

Section 1. Chemical Product and Company Identification Catalog Uranyl acetate dihydrate Common Name/U1005, U1006 Number(s). Trade Name CAS#6159-44-0; 541-09-3 (anhydrous) Manufacturer RTECSYR3675000 SPECTRUM CHEMICAL MFG. CORP. TSCA 8(b) inventory: No TSCA products were found. It is exempt from TSCA 8(b) Inventory listing since it is a hydrate. However the anhydrous form (CAS no. 541-06-3) is listed on the TSCA 8(b) Inventory. Commercial Name(s)Not available. CI#Not available. Bis(aceto)dioxouranium dihydrate; Synonym IN CASE OF EMERGENCY Bis(aceto-O)dioxouranium, dihydrate; Uranium, bis(aceto-O)dioxo-, dihydrate; Uranyl (2+) acetate, dihydrate; Uranium oxyacetate, dihydrate; Uranium acetate, dihydrate; Diacetatodioxouranium, dihydrate Chemical NameNot available. Not available.CALL (310) 516-8000 Chemical Family Chemical FormulaUO2(CH3COO)2.H2O SPECTRUM CHEMICAL MFG. CORP. Section 2.Composition and Information on Ingredients Exposure Limits NameCAS #TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3) % by Weight 1) Uranyl acetate dihydrate6159-44-00.2 0.6100 Uranyl acetate dihydrate: Toxicological Data ORAL (LD50):Acute: 204 mg/kg [Rat]. 242 mg/kg [Mouse]. on Ingredients Uranyl acetate dihydrate Section 3. Hazards Identification Potential Acute HealthHazardous in case of ingestion, of inhalation. Slightly hazardous in case of skin contact (irritant), of eye Effectscontact (irritant). Severe over-exposure can result in death. CARCINOGENIC EFFECTS: Classified A1 (Confirmed for human.) by ACGIH. Potential Chronic Health MUTAGENIC EFFECTS: Not available. Effects TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance may be toxic to kidneys, lungs, the nervous system, liver. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated exposure to a highly toxic material may produce general deterioration of health by an accumulation in one or many human organs. Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. Flush with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Cold water may be used. Get medical attention if irritation occurs. Seek medical attention in case of eye contact with a radioactive material. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Cold water may be used. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention immediately. Serious InhalationEvacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. WARNING: It may be hazardous to the person providing aid to give mouth-to-mouth resuscitation when the inhaled material is toxic, infectious or corrosive. If breathing is difficult, administer oxygen. If the victim is not breathing, perform mouth-to-mouth resuscitation. Seek medical attention in case of inhalation of a radioactive material. IngestionIf swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Not available. Flammable Limits These products are carbon oxides (CO, CO2). Products of Combustion Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various Substances Explosion Hazards inRisks of explosion of the product in presence of mechanical impact: Not available. Presence of VariousRisks of explosion of the product in presence of static discharge: Not available. Substances SMALL FIRE: Use DRY chemical powder. Fire Fighting Media LARGE FIRE: Use water spray, fog or foam. Do not use water jet. and Instructions Not available. Special Remarks on Fire Hazards Special Remarks on Explosion Not available. Hazards Uranyl acetate dihydrate Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Large SpillRadioactive material. Stop leak if without risk. Do not attempt recovery actions unless for rescue purposes. Do not touch damaged container or spilled material. Do not clean-up or dispose except under supervision of a specialist. Avoid contact with a combustible material (wood, paper, oil, clothing...). Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition sources. Be careful that the product is not present at a concentration level above TLV. Check TLV on the MSDS and with local authorities. Section 7. Handling and Storage Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do Precautions not breathe dust. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes Radioactive materials should be stored in a separate safety storage cabinet or room. Storage Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSafety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be a Large Spillused to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. TWA: 0.05 (mg/m3) (as U) from OSHA (PEL) [United States] (Uranium soluble compounds) Exposure Limits TWA: 0.2 STEL: 0.6 (as U) (mg/m3) from ACGIH (TLV) [United States] (Uranium compounds, n.o.s) TWA: 0.05 (mg/m3) (as U) from NIOSH [United States] (Uranium soluble compounds) TWA: 0.2 STEL: 0.6 (as U) (mg/m3) [Canada] Consult local authorities for acceptable exposure limits. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Crystalline solid.)OdorAcetic acid. (Slight.) Not available. Taste 424.15 g/mole Molecular Weight ColorYellow. pH (1% soln/water)Not available. Boiling PointNot available. Melting Point110°C (230°F) Deomposition Temperature: 275 deg. C Critical TemperatureNot available. Specific Gravity2.893 (Water = 1) Vapor PressureNot applicable. Not available. Vapor Density VolatilityNot available. Not available. Odor Threshold Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesSee solubility in water. Uranyl acetate dihydrate Partially soluble in cold water. Solubility Freely soluble in water acidulated with acetic acid. Solubility in water: 7.694 g/100 ml @ 15 deg. C. Decomposes in hot water. Soluble in 10 parts of water, usually incompletely, due to the presence of the basic salt. Very soluble in alcohol. Section 10. Stability and Reactivity Data The product is stable. Stability Instability TemperatureNot available. Conditions of InstabilityExcess heat, incompatible materials Incompatibility with various Reactive with oxidizing agents. substances Non-corrosive in presence of glass. Corrosivity Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationNo. Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 204 mg/kg [Rat]. Chronic Effects on Humans May cause damage to the following organs: kidneys, lungs, the nervous system, liver. Other Toxic Effects onHazardous in case of ingestion, of inhalation. HumansSlightly hazardous in case of skin contact (irritant). Special Remarks onNot available. Toxicity to Animals Special Remarks onMay cause adverse reproductive effects and birth defects (teratogenic). Chronic Effects on Humans May cause cancer Special Remarks on otherRadioactive Material with low specific activity. Toxic Effects on HumansAcute Potential Health Effects: Skin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May be harmful by inhalation. May cause respiratory tract (nose, throat, lungs) and mucous membrane irritation. Symptoms may include coughing, wheezing and/or shortness of breath. Ingestion: Harmful if swallowed. May affect behavior/central nervous system (tremor), blood (changes in serum composition, anemia), metabolism (loss of appetite), urinary system (renal function tests depressed) Chronic Potential Health Effects: Ingestion: Danger of cumulative effects. May affect blood (changes in red blood cell count, changes in blood serum composition, anemia), metabolism (weight loss), liver, brain. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. The products of degradation are as toxic as the original product. Toxicity of the Products of Biodegradation Uranyl acetate dihydrate Not available. Special Remarks on the Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationCLASS 7: Radioactive material. UNNA: 2910: Radioactive material, excepted package-limited quantity of material (Uranyl Acetate dihydrate) Identification PG: Not available. Not available. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms Federal and StateCalifornia prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer, birth defects or other reproductive harm, which would require a warning under the Regulations statute: Uranyl acetate dihydrate California prop. 65: This product contains the following ingredients for which the State of California has found to cause cancer which would require a warning under the statute: Uranyl acetate dihydrate New York release reporting list: Uranyl acetate Pennsylvania RTK: Uranyl acetate Minnesota: Uranyl acetate dihydrate (Listed as Uranium soluble compounds) Massachusetts RTK: Uranyl acetate New Jersey: Uranyl acetate New Jersey spill list: Uranyl acetate Louisiana spill reporting: Uranyl acetate California Director's List of Hazardous Substances: Uranyl acetate dihydrate (Listed as Uranium compounds, n.o.s) TSCA 8(b) inventory: No products were found. CERCLA: Hazardous substances.: Uranyl acetate: 100 lbs. (45.36 kg) CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has Proposition 65found to cause cancer which would require a warning under the statute: Uranyl acetate dihydrate Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances. Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List (NDSL). China: Listed on National Inventory. Japan: Not listed on National Inventory (ENCS). Korea: Not listed on National Inventory (KECI). Philippines: Not listed on National Inventory (PICCS). Australia: Listed on AICS. Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC)R26/28- Very toxic by inhalation andS20/21- When using do not eat, drink or if swallowed.smoke. R33- Danger of cumulative effects.S45- In case of accident or if you feel unwell, R51/53- Toxic to aquatic organisms,seek medical advice immediately (show the may cause long-term adverse effectslabel where possible). in the aquatic environment.S61- Avoid release to the environment. Refer to special instructions/Safety data sheets. Uranyl acetate dihydrate Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection x WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Wear appropriate respirator when ventilation is inadequate. Uranyl acetate dihydrate CALL (310) 516-8000 Notice to Reader All chemicals may pose unknown hazards and should be used with caution. This Material Safety Data Sheet (MSDS) applies only to the material as packaged. If this product is combined with other materials, deteriorates, or becomes contaminated, it may pose hazards not mentioned in this MSDS. It shall be the user's responsibility to develop proper methods of handling and personal protection based on the actual conditions of use. While this MSDS is based on technical data judged to be reliable, Spectrum Quality Products, SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : YR3600000 CHEMICAL NAME : Uranium, bis(acetato)dioxo-, dihydrate CAS REGISTRY NUMBER : 6159-44-0 LAST UPDATED : 199806 DATA ITEMS CITED : 15 MOLECULAR FORMULA : C4-H6-O6-U.2H2-O MOLECULAR WEIGHT : 424.14 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 204 mg/kg TOXIC EFFECTS : Behavioral - tremor Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 39,168,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 8300 ug/kg TOXIC EFFECTS : Behavioral - tremor Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 39,168,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 242 mg/kg TOXIC EFFECTS : Behavioral - tremor Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 39,168,1987 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 20400 ug/kg TOXIC EFFECTS : Behavioral - tremor Skin and Appendages - hair Nutritional and Gross Metabolic - body temperature decrease REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 39,168,1987 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 5350 ug/kg TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in both tubules and glomeruli REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 7,32,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 448 mg/kg/4W-C TOXIC EFFECTS : Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation REFERENCE : BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 42,935,1989 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 50 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 55,143,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 100 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 55,143,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 2 gm/kg SEX/DURATION : male 60 day(s) pre-mating female 2 week(s) pre-mating female 1-13 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 17,291,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 990 mg/kg SEX/DURATION : male 60 day(s) pre-mating female 14 day(s) pre-mating - 4 day(s) post-birth TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects REFERENCE : EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 17,291,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 640 mg/kg SEX/DURATION : male 64 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,821,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1280 mg/kg SEX/DURATION : male 64 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct REFERENCE : FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 16,821,1991 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral DOSE : 1500 mg/kg SEX/DURATION : female 13-21 day(s) after conception lactating female 21 day(s) post-birth TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive - Effects on Newborn - other postnatal measures or effects REFERENCE : AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 44,395,1989 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 4 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 79,149,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous DOSE : 5 mg/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Maternal Effects - other effects Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: (Suppl),269,1992

安全

• 危害码 (欧洲): T+,R,N
• 风险声明 (欧洲): R26/28
• 安全声明 (欧洲): 20/21-45-61
• 危险品运输编码: UN 2910 7
• RTECS号: YR3600000
• 海关编码: 2845900090

制备

在热乙酸溶液中加入三氧化铀，过滤，然后浓缩，冷却结晶，最后用水洗涤即得：

海关

海关编码	2845900090