4561-43-7

• 常用中文名：ALPHA-羟基-苯乙胺盐酸盐
• 常用英文名：2-Amino-1-phenylethanol hydrochloride
• CAS号：4561-43-7
• 分子式：C₈H₁₂ClNO
• 分子量：173.640
• 发布时间：2018-08-16 13:29:42
• 更新时间：2024-03-15 12:20:44

名称

• 中文名: ALPHA-羟基-苯乙胺盐酸盐
• 英文名: 2-Amino-1-phenylethanol hydrochloride
• 英文别名: (+-)-2-amino-1-phenyl-ethanol,hydrochloride; 2-Amino-1-phenyl-butandion-(1,3); Benzeneethanaminium, β-hydroxy-, chloride (1:1); (+-)-2-Amino-1-phenyl-aethanol,Hydrochlorid; 1,3-Butanedione,2-amino-1-phenyl; amino-2 phenyl-1 ethanol chlorhydrate; β-Hydroxyphenethylamine, hydrochloride; 2-Hydroxy-2-phenylethanaminium chloride; benzenemethanol, α-(aminomethyl)-, hydrochloride (1:1); 2-Amino-1-phenylethanol hydrochloride (1:1); β-Phenyl-β-hydroxy-ethylamine, hydrochloride; (+/-)-2-Hydroxy-2-phenylethylaminhydrochlorid; 2-amino-1-phenyl-1,3-butadione; l-2-hydroxy-2-phenylethylamine,hydrochloride; α-(Aminomethyl)benzyl alcohol, hydrochloride

物化性质

• 沸点: 283.5ºC at 760 mmHg
• 分子式: C₈H₁₂ClNO
• 分子量: 173.640
• 闪点: 125.3ºC
• 精确质量: 173.060745
• PSA: 46.25000
• LogP: 2.18100

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : DN7175000 CHEMICAL NAME : Benzyl alcohol, alpha-(aminomethyl)-, hydrochloride CAS REGISTRY NUMBER : 4561-43-7 LAST UPDATED : 199712 DATA ITEMS CITED : 7 MOLECULAR FORMULA : C8-H11-N-O.Cl-H MOLECULAR WEIGHT : 173.66 WISWESSER LINE NOTATION : Z1YQR &GH HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 9,203,1936 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 237,171,1959 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 275 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 9,203,1936 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 38 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 32,121,1927 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 886 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 32,121,1927 *** REVIEWS *** TOXICOLOGY REVIEW CHREAY Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1924- Volume(issue)/page/year: 9,389,1931

合成路线

614-21-1 ~83% 4561-43-7

文献：Tamura, Rui; Oda, Daihei; Kurokawa, Hiroshi Tetrahedron Letters, 1986 , vol. 27, # 47 p. 5759 - 5762

614-21-1 ~0% 5468-37-1 4561-43-7

文献：Tamura, Rui; Oda, Daihei; Kurokawa, Hiroshi Tetrahedron Letters, 1986 , vol. 27, # 47 p. 5759 - 5762

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