877384-16-2

• 常用中文名：[(1S,2R)-2-[3,5-双(三氟甲基)苯基]-2-羟基-1-甲基乙基]氨基甲酸苄酯
• 常用英文名：BENZYL ((1R,2S)-1-(3,5-BIS(TRIFLUOROMETHYL)PHENYL)-1-HYDROXYPROPAN-2-YL)CARBAMATE
• CAS号：877384-16-2
• 分子式：C₁₉H₁₇F₆NO₃
• 分子量：421.334
• 发布时间：2018-06-20 09:43:14
• 更新时间：2024-02-01 22:17:06

名称

• 中文名: (1r,2s)-1-(3,5-双(三氟甲基)苯基)-1-羟基丙烷-2-氨基甲酸苄酯
• 英文名: benzyl N-[(1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-1-hydroxypropan-2-yl]carbamate
• 英文别名: Carbamic acid, N-[(1S,2R)-2-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxy-1-methylethyl]-, phenylmethyl ester; [(1S,2R)-2-[3,5-Bis(trifluoromethyl)phenyl]-2-hydroxy-1-methylethyl]carbamic acid phenylmethyl ester; Benzyl {(1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-1-hydroxy-2-propanyl}carbamate; benzyl (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-ylcarbamate; (1R,2S)-1-(3',5'-bis(trifluoromethyl)phenyl)-2-benzyloxycarbonylamino-1-propanol; Anacetrapib Intermediate 1

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 442.8±45.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇F₆NO₃
• 分子量: 421.334
• 闪点: 221.6±28.7 °C
• 精确质量: 421.111267
• PSA: 58.56000
• LogP: 4.71
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.498
• 储存条件: 2-8°C，干燥，密封

安全

• 危害码 (欧洲): Xi

合成路线

871917-79-2 ~% 877384-16-2

文献：MERCK and CO., INC. Patent: WO2006/14357 A1, 2006 ; Location in patent: Page/Page column 51-52 ;

1142-20-7 ~% 877384-16-2

文献：Smith, Cameron J.; Ali, Amjad; Hammond, Milton L.; Li, Hong; Lu, Zhijian; Napolitano, Joann; Taylor, Gayle E.; Thompson, Christopher F.; Anderson, Matt S.; Chen, Ying; Eveland, Suzanne S.; Guo, Qiu; Hyland, Sheryl A.; Milot, Denise P.; Sparrow, Carl P.; Wright, Samuel D.; Cumiskey, Anne-Marie; Latham, Melanie; Peterson, Laurence B.; Rosa, Ray; Pivnichny, James V.; Tong, Xinchun; Xu, Suoyu S.; Sinclair, Peter J. Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4880 - 4895

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