875444-08-9

• 常用中文名：(4S,5R)-4-甲基-5-[3,5-双(三氟甲基)苯基]噁唑烷-2-酮
• 常用英文名：(4R,5S)-5-(3,5-bis(trifluoroMethyl)phenyl)-4-Methyloxazolidin-2-one
• CAS号：875444-08-9
• 分子式：C₁₂H₉F₆NO₂
• 分子量：313.196
• 发布时间：2018-12-26 08:23:03
• 更新时间：2024-01-03 19:15:19

名称

• 中文名: (4S,5R)-5-(3,5-双(三氟甲基)苯基)-4-(甲基-1,3-噁唑烷-2-酮
• 英文名: (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one
• 中文别名: (4S,5R)-5-(3,5-双(三氟甲基)苯基)-4-甲基噁唑啉-2-酮
• 英文别名: (4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-1,3-oxazolidin-2-one; 2-Oxazolidinone, 5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-, (4S,5R)-; 2-Oxazolidinone,5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-,(4S,5R); (4S,5R)-5-(3,5-bis-trifluoromethyl-phenyl)-4-methyl-oxazolidin-2-one; (4S,5R)-5-[3,5-Bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one; (4R,5S)-5-(3,5-bis(trifluoroMethyl)phenyl)-4-Methyloxazolidin-2-one; Anacetrapib Intermediate 2

物化性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 329.5±42.0 °C at 760 mmHg
• 分子式: C₁₂H₉F₆NO₂
• 分子量: 313.196
• 闪点: 153.1±27.9 °C
• 精确质量: 313.053741
• PSA: 38.33000
• LogP: 3.31
• 蒸汽压: 0.0±0.7 mmHg at 25°C
• 折射率: 1.433
• 储存条件: 室温，干燥

合成路线

871917-79-2 ~98% 875444-08-9

文献：MERCK and CO., INC. Patent: WO2007/81569 A2, 2007 ; Location in patent: Page/Page column 34-35 ;

877384-16-2 ~% 875444-08-9

文献：MERCK and CO., INC. Patent: WO2006/14357 A1, 2006 ; Location in patent: Page/Page column 51-52 ;

1182350-90-8 ~% 875444-08-9

文献：AMIRA PHARMACEUTICALS, INC. Patent: WO2009/108720 A2, 2009 ; Location in patent: Page/Page column 132 ; WO 2009/108720 A2

1402799-12-5 1402799-13-6 1152029-16-7 1402799-11-4 32315-10-9 详细

文献：MERCK and CO., INC. Patent: WO2007/81571 A2, 2007 ; Location in patent: Page/Page column 41 ;

17352-25-9 ~% 875444-08-9

文献：Ogawa, Takanori; Kumagai, Naoya; Shibasaki, Masakatsu Angewandte Chemie - International Edition, 2013 , vol. 52, # 24 p. 6196 - 6201 Angew. Chem., 2013 , vol. 125, # 24 p. 6316 - 6321

上下游产品

上游产品  5
877384-16-2 1182350-90-8 1152029-16-7 32315-10-9
17352-25-9
下游产品  1
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