CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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AI5200000
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CHEMICAL NAME :
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Acetic acid, lead salt
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CAS REGISTRY NUMBER :
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15347-57-6
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LAST UPDATED :
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199509
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DATA ITEMS CITED :
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18
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MOLECULAR FORMULA :
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C2-H4-O2.xPb
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MOLECULAR WEIGHT :
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1510.39
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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286 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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399 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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13 gm/kg/13W-I
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TOXIC EFFECTS :
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Spinal Cord - other degenerative changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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7 gm/kg/10W-C
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - other changes in urine composition Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes Biochemical - Metabolism (Intermediary) - porphyrin including bile pigments
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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348 mg/kg/8W-I
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TOXIC EFFECTS :
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Peripheral Nerve and Sensation - recording from peripheral motor nerve
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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60 mg/kg/30D-I
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TOXIC EFFECTS :
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Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in adrenal weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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42 mg/kg/10W-I
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TOXIC EFFECTS :
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Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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1250 mg/kg/25D-I
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TOXIC EFFECTS :
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Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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18900 ug/kg
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SEX/DURATION :
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male 9 week(s) pre-mating
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TOXIC EFFECTS :
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Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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4400 mg/kg
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SEX/DURATION :
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lactating female 22 day(s) post-birth
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - biochemical and metabolic
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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DOSE :
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50 mg/kg
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SEX/DURATION :
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female 18 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Effects on Newborn - biochemical and metabolic
MUTATION DATA
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TYPE OF TEST :
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Cytogenetic analysis
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TEST SYSTEM :
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Human Leukocyte
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DOSE/DURATION :
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10 umol/L
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REFERENCE :
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EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 30,1006,1974
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