910-86-1

• 常用中文名：硫卡利特
• 常用英文名：Thiocarlide
• CAS号：910-86-1
• 分子式：C₂₃H₃₂N₂O₂S
• 分子量：400.577
• 相关类别： 化学试剂 有机试剂 硫脲
• 发布时间：2018-06-16 21:36:38
• 更新时间：2024-01-12 21:59:14
• Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB).

名称

• 中文名: 戊氧苯硫脲
• 英文名: 1,3-bis[4-(3-methylbutoxy)phenyl]thiourea
• 中文别名: 硫卡利特; 肺速舒
• 英文别名: Tiocarlida; 4-13-00-01187 (Beilstein Handbook Reference); Sarbamyl; Thiocarlide; 1,3-Bis(p-isoamyloxyphenyl)-2-thiourea; 4,4'-Di(isoamyloxy)thiocarbanilide; Amixyl; Tiocarlid; DATC; Thiourea, N,N'-bis[4-(3-methylbutoxy)phenyl]-; Thiourea, N,N'-bis(4-(3-methylbutoxy)phenyl)-; 1,3-Bis[4-(3-methylbutoxy)phenyl]thiourea; Thiourea, N,N'-bis(4-(3-methylbutoxy)phenyl)- (9CI); Tiocarlidum; Disoxyl; tiocarlide; N,N'-[4-(3-Methylbutoxy)phenyl]thiourea; Isoxyl

物化性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 508.5±60.0 °C at 760 mmHg
• 熔点: 134-145°
• 分子式: C₂₃H₃₂N₂O₂S
• 分子量: 400.577
• 闪点: 261.3±32.9 °C
• 精确质量: 400.218445
• PSA: 74.61000
• LogP: 6.12
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.600
• 储存条件: -20°C，密闭，干燥

合成路线

463-71-8 5198-05-0 ~50% 910-86-1

文献：Brown, Joshua R.; North, Elton J.; Hurdle, Julian G.; Morisseau, Christophe; Scarborough, Jerrod S.; Sun, Dianqing; Kordulakova, Jana; Scherman, Michael S.; Jones, Victoria; Grzegorzewicz, Anna; Crew, Rebecca M.; Jackson, Mary; McNeil, Michael R.; Lee, Richard E. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5585 - 5595

75-15-0 5198-05-0 ~54% 910-86-1

文献：Bhowruth, Veemal; Brown, Alistair K.; Reynolds, Robert C.; Coxon, Geoffrey D.; Mackay, Simon P.; Minnikin, David E.; Besra, Gurdyal S. Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 18 p. 4743 - 4747

100-02-7 ~% 910-86-1

文献：Brown, Joshua R.; North, Elton J.; Hurdle, Julian G.; Morisseau, Christophe; Scarborough, Jerrod S.; Sun, Dianqing; Kordulakova, Jana; Scherman, Michael S.; Jones, Victoria; Grzegorzewicz, Anna; Crew, Rebecca M.; Jackson, Mary; McNeil, Michael R.; Lee, Richard E. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5585 - 5595

7244-79-3 ~% 910-86-1

文献：Brown, Joshua R.; North, Elton J.; Hurdle, Julian G.; Morisseau, Christophe; Scarborough, Jerrod S.; Sun, Dianqing; Kordulakova, Jana; Scherman, Michael S.; Jones, Victoria; Grzegorzewicz, Anna; Crew, Rebecca M.; Jackson, Mary; McNeil, Michael R.; Lee, Richard E. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5585 - 5595

107-82-4 ~% 910-86-1

文献：Brown, Joshua R.; North, Elton J.; Hurdle, Julian G.; Morisseau, Christophe; Scarborough, Jerrod S.; Sun, Dianqing; Kordulakova, Jana; Scherman, Michael S.; Jones, Victoria; Grzegorzewicz, Anna; Crew, Rebecca M.; Jackson, Mary; McNeil, Michael R.; Lee, Richard E. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5585 - 5595

5198-05-0 ~% 910-86-1

文献：CIBA Patent: US2703815 , 1951 ; Full Text Show Details CIBA Patent: DE923446 , 1952 ;

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