58-71-9

• 常用中文名：先锋霉素 钠盐
• 常用英文名：Cephalothin Sodium
• CAS号：58-71-9
• 分子式：C₁₆H₁₅N₂NaO₆S₂
• 分子量：418.420
• 相关类别： 原料药 抗生素类药物 头孢菌素类药
• 发布时间：2018-02-06 08:00:00
• 更新时间：2024-01-03 20:57:16
• Cephalothin钠是第一代头孢类抗生素, 具有广泛的抗菌活性,有效抗革兰氏阳性和阴性菌。
• 头孢噻吩钠通过抑制细胞壁的合成，使细胞内容物膨胀至破裂溶解，从而达到杀菌作用。该品为广谱抗生素。对革兰氏阳性菌和革兰氏阴性菌均有抗菌作用，注射后吸收迅速而完全，生物利用率高。头孢噻吩钠属第一代头孢菌素，抗菌谱与头孢噻吩相仿，但其抗菌活性较后者为差。除肠球菌属、甲氧西林耐药葡萄球菌外，肺炎链球菌、溶血性链球菌、产或不产青霉素酶葡萄球菌的大部分菌株对该品敏感。该品对奈瑟菌属有较好抗菌作用，但流感嗜血杆菌对该品的敏感性较差；该品对部分大肠埃希菌、奇异变形杆菌、沙门菌和志贺菌有一定抗菌作用。其余肠杆菌科细菌、不动杆菌、铜绿假单胞菌、脆弱拟杆菌均对该品呈现耐药。梭杆菌属和韦容球菌一般对该品敏感，厌氧革兰阳性球菌对该品中度敏感。

名称

• 中文名: 头孢噻吩钠
• 英文名: cephalothin sodium
• 中文别名: 头孢霉素1; 头孢噻吩; (6R,7R)-3-乙酰氧甲基-8-氧代-7-[2-(噻吩-2-基)乙酰氨基]-5-硫杂-1-氮杂双环[4.2.0.]辛-2-烯-2-甲酸钠; 头孢菌素I; 头孢金素
• 英文别名: sodium (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[2-(2-thienyl)acetyl]amino]-, sodium salt, (6R,7R)- (1:1); Sodium (6R,7R)-3-(acetoxymethyl)-8-oxo-7-[(2-thienylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; Cephalothin Sodium; Cephalothin; EINECS 200-394-6; MFCD00072025; Cephalothin sodium salt; Cephalothin (sodium)

物化性质

• 沸点: 757.2ºC at 760 mmHg
• 熔点: 240°C
• 分子式: C₁₆H₁₅N₂NaO₆S₂
• 分子量: 418.420
• 闪点: 411.8ºC
• 精确质量: 418.026917
• PSA: 169.38000
• 外观性状: 气味
• 储存条件:

  本品应密封于4℃干燥避光保存。

• 水溶解性: 158 mg/L
• 计算化学:

  1、 计疏水参数计算参考值（XlogP）：

  2、 氢键供体数量：1

  3、 氢键受体数量：6

  4、 可旋转化学键数量：7

  5、 互变异构体数量：2

  6、 拓扑分子极性表面积（TPSA）：116

  7、 重原子数量：27

  8、 表面电荷：0

  9、 复杂度：686

  10、同位素原子数量：0

  11、确定原子立构中心数量：2

  12、不确定原子立构中心数量：0

  13、确定化学键立构中心数量：0

  14、不确定化学键立构中心数量：0

  15、共价键单元数量：2

• 更多:

  1. 性状：白色结晶性粉末。

  2. 密度（g/mL,25/4℃）： 未确定。

  3. 相对蒸汽密度（g/mL,空气=1）：未确定

  4. 熔点（ºC）：204～205

  5. 沸点（ºC,常压）：未确定

  6. 沸点（ºC,5.2kPa）：未确定

  7. 折射率：未确定

  8. 闪点（ºC）：未确定

  9. 比旋光度（º）：[α]D +135°（C=1，水中）

  10. 自燃点或引燃温度（ºC）：未确定

  11. 蒸气压（kPa,25ºC）：未确定

  12. 饱和蒸气压（kPa,60ºC）：未确定

  13. 燃烧热（KJ/mol）：未确定

  14. 临界温度（ºC）：未确定

  15. 临界压力（KPa）：未确定

  16. 油水（辛醇/水）分配系数的对数值：未确定

  17. 爆炸上限（%,V/V）：未确定

  18. 爆炸下限（%,V/V）：未确定

  19. 溶解性：易溶于水（250～300mg/ml）。水溶液在低温时比较稳定。

生物活性

• 描述: Cephalothin钠是第一代头孢类抗生素, 具有广泛的抗菌活性,有效抗革兰氏阳性和阴性菌。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 感染

MSDS

Material Safety Data Sheet Section1. Identification of the substance Product Name: Cefalotin sodium salt Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. H334:May cause allergy or asthma symptoms or breathing difficulties if inhaled H317:May cause an allergic skin reaction P285:In case of inadequate ventilation wear respiratory protection P280:Wear protective gloves/protective clothing/eye protection/face protection P342+P311:If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician P363:Wash contaminated clothing before reuse P304+P341:IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing Section3. Composition/information on ingredients. Ingredient name:Cefalotin sodium salt CAS number:58-71-9 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Storage:Store in closed vessels. Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Not specified Appearance: Boiling point:No data Melting point:No data Flash point:No data Density:No data Molecular formula:C16H15N2O6S2.Na Molecular weight:418.4 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : XI0388300 CHEMICAL NAME : 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-(2-(2- thienyl)acetamido)-, acetate, monosodium salt CAS REGISTRY NUMBER : 58-71-9 LAST UPDATED : 199609 DATA ITEMS CITED : 27 MOLECULAR FORMULA : C16-H15-N2-O6-S2.Na MOLECULAR WEIGHT : 418.44 WISWESSER LINE NOTATION : T46 ANV ES GUTJ G1OV1 HVO CMV1- BT5SJ &-NA- HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - woman DOSE/DURATION : 20 mg/kg TOXIC EFFECTS : Blood - thrombocytopenia REFERENCE : AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 77,401,1972 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - child DOSE/DURATION : 89 mg/kg/19D-I TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,272,1963 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Human - man DOSE/DURATION : 955 mg/kg/22D-I TOXIC EFFECTS : Blood - agranulocytosis REFERENCE : AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year: -,272,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 27,746,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 18,185,1971 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7500 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema REFERENCE : CLMEA3 Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85, 1940-78. Volume(issue)/page/year: 70,1123,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 5600 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 28,231,1975 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >20 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 28,81,1975 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 5670 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 27,746,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JACHDX Journal of Antimicrobial Chemotherapy. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975- Volume(issue)/page/year: 6(Suppl A),79,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4800 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 27,746,1974 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >4 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 1,67,1972 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 6 gm/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 28,205,1975 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - cat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : >2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904- Volume(issue)/page/year: 137,S51,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 110 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : CLMEA3 Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85, 1940-78. Volume(issue)/page/year: 70,1123,1963 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : CLMEA3 Clinical Medicine. (Northfield, IL) V.31-33, 1924-26; V.47-85, 1940-78. Volume(issue)/page/year: 70,1123,1963 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 96 gm/kg/30D-I TOXIC EFFECTS : Liver - changes in liver weight Endocrine - changes in adrenal weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 27,746,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 78 gm/kg/26W-I TOXIC EFFECTS : Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 28,195,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 63 gm/kg/21D-I TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory stimulation Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 26(Suppl 1),185,1978 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 72900 mg/kg/31D-I TOXIC EFFECTS : Gastrointestinal - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 28,231,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 48 gm/kg/30D-I TOXIC EFFECTS : Endocrine - changes in thyroid weight Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 27,746,1974 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 52 gm/kg/30D-I TOXIC EFFECTS : Gastrointestinal - nausea or vomiting Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 28,205,1975 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 15 gm/kg/10D-I TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting REFERENCE : JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968- Volume(issue)/page/year: 28,205,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83944 No. of Facilities: 33 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1650 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83944 No. of Facilities: 620 (estimated) No. of Industries: 1 No. of Occupations: 11 No. of Employees: 22644 (estimated) No. of Female Employees: 18457 (estimated)

安全

• 符号: GHS08
• 信号词: Danger
• 危害声明: H317-H334
• 警示性声明: P261-P280-P284-P304 + P340-P342 + P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Faceshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R42/43
• 安全声明 (欧洲): S22-S36/37
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 2
• RTECS号: XI0388300
• 海关编码: 3003201900

合成路线

153-61-7 ~26% 58-71-9

文献：Cowley; Humber; Laundon; et al. Tetrahedron, 1983 , vol. 39, # 3 p. 461 - 467

39098-97-0 957-68-6 ~% 58-71-9

文献：Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1815 - 1822

上下游产品

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153-61-7 39098-97-0 957-68-6
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制备

以发酵生产的头孢菌素C为原料，经保护性水解得7-氨基头孢烷酸（7-ACA），与噻吩乙酰氯缩合，所得产物经乙酸丁酯提取，活性炭脱色，最后加入甲醇醋酸钠成盐，结晶而得头孢噻吩钠。

海关

海关编码	3003201900