CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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CL7618500
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CHEMICAL NAME :
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2-Aza-8-germaspiro(4.5)decane-2-propanamine, 8,8-diethyl-N,N-dimethyl, dihydrochloride
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CAS REGISTRY NUMBER :
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41992-22-7
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LAST UPDATED :
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198605
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DATA ITEMS CITED :
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6
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MOLECULAR FORMULA :
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C17-H36-Ge-N2.2Cl-H
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MOLECULAR WEIGHT :
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414.06
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WISWESSER LINE NOTATION :
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T6-GE- DXTJ A2 A2 D-& CT5N CXTJ A3N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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107 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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210 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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41500 ug/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB264-117
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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119 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Blood - hemorrhage Blood - other changes
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REFERENCE :
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CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intravenous
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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40 mg/kg
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TOXIC EFFECTS :
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Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
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REFERENCE :
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CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
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TYPE OF TEST :
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LDLo - Lowest published lethal dose
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ROUTE OF EXPOSURE :
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Intramuscular
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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40 mg/kg
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TOXIC EFFECTS :
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Behavioral - convulsions or effect on seizure threshold Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
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REFERENCE :
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CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 64,1207,1980
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