194918-76-8

• 常用中文名：ACPT-1
• 常用英文名：ACPT-1
• CAS号：194918-76-8
• 分子式：C₈H₁₁NO₆
• 分子量：217.17600
• 发布时间：2016-02-27 21:55:40
• 更新时间：2024-01-02 18:08:47
• rel-ACPT-I是III类mGluR的激动剂,具有多种生物活性,包括神经保护、抗惊厥和抗焦虑样作用[1][2][3][4][5]。

名称

• 英文名: acpt-i

物化性质

• 分子式: C₈H₁₁NO₆
• 分子量: 217.17600
• 精确质量: 217.05900
• PSA: 137.92000
• 储存条件: -20°C，密闭，干燥

生物活性

• 描述: rel-ACPT-I是III类mGluR的激动剂,具有多种生物活性,包括神经保护、抗惊厥和抗焦虑样作用[1][2][3][4][5]。
• 参考文献:

  [1]. Acher FC, et al. Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes. J Med Chem. 1997 Sep 12;40(19):3119-29.

  [2]. Domin H, et al. Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: In vitro and in vivo studies. Neuropharmacology. 2016 Mar;102:276-94.

  [3]. Domin H, et al. Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Neurotox Res. 2014 Jul;26(1):99-113.

  [4]. Chapman AG, et al. Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid. Eur J Pharmacol. 2001 Jul 20;424(2):107-13.

  [5]. Stachowicz K, et al. The group III mGlu receptor agonist ACPT-I exerts anxiolytic-like but not antidepressant-like effects, mediated by the serotonergic and GABA-ergic systems. Neuropharmacology. 2009 Sep;57(3):227-34.

合成路线

194918-80-4 ~% 194918-76-8

文献：Acher, Francine C.; Tellier, Frederique J.; Azerad, Robert; Brabet, Isabelle N.; Fagni, Laurent; Pin, Jean R. Journal of Medicinal Chemistry, 1997 , vol. 40, # 19 p. 3119 - 3129