- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：4-(N-马来酰亚胺基甲基)环己基甲酸
- 纯度：98.0%
- 规格：
- 联系人：徐经理
- 联系电话：13311869306
- 上海阿拉丁生化科技股份有限公司
- 上海市 上海市 浦东新区
- 产品名：N-[4-（-羧基环己基甲基）]马来酰亚胺
- 纯度：98.0%
- 规格：1g/25g/5g/1g
- 联系人：阿拉丁
- 联系电话：400-620-6333
- 上海创赛科技有限公司
- 上海市 上海市 嘉定区
- 产品名：[Perfemiker]4-(N-马来酰亚胺基甲基)环己烷-1-甲酸,≥98%
- 纯度：98.0%
- 规格：50mg/200mg/1g
- 联系人：夏言
- 联系电话：18016376636
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64987-82-2
64987-82-2结构式
- 常用中文名：4-(N-马来酰亚胺基甲基)环己烷-1-甲酸
- 常用英文名：N-(4-Carboxycyclohexylmethyl)maleimide
- CAS号：64987-82-2
- 分子式：C12H15NO4
- 分子量：237.252
- 相关类别： 信号通路 蛋白裂解靶向嵌合体 PROTAC Linker
- 发布时间：2018-12-25 21:29:05
- 更新时间：2024-01-14 20:01:35
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N-(4-Carboxycyclohexylmethyl)maleimide 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。
| 中文名 | 4-(N-马来酰亚胺基甲基)环己基甲酸 |
|---|---|
| 英文名 | N-[4-(-Carboxycyclohexylmethyl)]maleimide |
| 中文别名 | 4-(马来酰亚胺甲基)环己烷羧酸 |
| 英文别名 |
Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-
4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid |
| 描述 | N-(4-Carboxycyclohexylmethyl)maleimide 是一种 PROTAC linker,属于 alkyl chain 类。可用于合成 PROTAC 分子。 |
|---|---|
| 相关类别 | |
| 靶点 |
Alkyl-Chain |
| 体外研究 | PROTACs包含两种不同的配体,它们通过连接体连接；一种是E3泛素连接酶的配体,另一种是靶蛋白的配体。PROTACs利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白[1]。 |
| 参考文献 |
| 密度 | 1.3±0.1 g/cm3 |
|---|---|
| 沸点 | 433.6±18.0 °C at 760 mmHg |
| 熔点 | 157-158ºC |
| 分子式 | C12H15NO4 |
| 分子量 | 237.252 |
| 闪点 | 216.0±21.2 °C |
| 精确质量 | 237.100113 |
| PSA | 74.68000 |
| LogP | 1.13 |
| 蒸汽压 | 0.0±2.2 mmHg at 25°C |
| 折射率 | 1.568 |
| 储存条件 | -20°C |
|
Material Safety Data Sheet
Section1. Identification of the substance Product Name: N-[4-(-Carboxycyclohexylmethyl)]maleimide Synonyms: Section2. Hazards identification Harmful by inhalation, in contact with skin, and if swallowed. Section3. Composition/information on ingredients. Ingredient name:N-[4-(-Carboxycyclohexylmethyl)]maleimide CAS number:64987-82-2 Section4. First aid measures Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. If irritation persists, seek medical attention. Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical attention. Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention. Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention. Section5. Fire fighting measures In the event of a fire involving this material, alone or in combination with other materials, use dry powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus should be worn. Section6. Accidental release measures Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national standards. Respiratory precaution:Wear approved mask/respirator Hand precaution:Wear suitable gloves/gauntlets Skin protection:Wear suitable protective clothing Eye protection:Wear suitable eye protection Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container for disposal. See section 12. Environmental precautions: Do not allow material to enter drains or water courses. Section7. Handling and storage Handling:This product should be handled only by, or under the close supervision of, those properly qualified in the handling and use of potentially hazardous chemicals, who should take into account the fire, health and chemical hazard data given on this sheet. Store in closed vessels, refrigerated. Storage: Section8. Exposure Controls / Personal protection Engineering Controls: Use only in a chemical fume hood. Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles. General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse. Section9. Physical and chemical properties Appearance:Not specified Boiling point:No data No data Melting point: Flash point:No data Density:No data Molecular formula:C12H15NO4 Molecular weight:237.3 Section10. Stability and reactivity Conditions to avoid: Heat, flames and sparks. Materials to avoid: Oxidizing agents. Possible hazardous combustion products: Carbon monoxide, nitrogen oxides. Section11. Toxicological information No data. Section12. Ecological information No data. Section13. Disposal consideration Arrange disposal as special waste, by licensed disposal company, in consultation with local waste disposal authority, in accordance with national and regional regulations. Section14. Transportation information Non-harzardous for air and ground transportation. Section15. Regulatory information No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302, or have known CAS numbers that exceed the threshold reporting levels established by SARA Title III, Section 313. SECTION 16 - ADDITIONAL INFORMATION N/A |
| 海关编码 | 2925190090 |
|---|
| 海关编码 | 2925190090 |
|---|---|
| 中文概述 | 2925190090 其他酰亚胺及其衍生物盐. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0% |
| 申报要素 | 品名, 成分含量, 用途 |
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |