55984-51-5

• 常用中文名：2-Propanone, 1-(methylnitrosoamino)- (9CI)
• 常用英文名：2-Propanone, 1-(methylnitrosoamino)- (9CI)
• CAS号：55984-51-5
• 分子式：C₄H₈N₂O₂
• 分子量：116.11900
• 发布时间：2016-07-01 01:41:23
• 更新时间：2024-01-09 17:23:56

名称

• 英文名: N-methyl-N-(2-oxopropyl)nitrous amide
• 英文别名: N-Nitrosomethyl-2-oxopropylamine; methyl-2-oxopropylnitrosamine; N0nitrosomethyl-N-2-oxopropylamine; N-nitrosomethyl-N-2-oxopropylamine

物化性质

• 密度: 1.1g/cm3
• 沸点: 241.1ºC at 760mmHg
• 分子式: C₄H₈N₂O₂
• 分子量: 116.11900
• 闪点: 99.6ºC
• 精确质量: 116.05900
• PSA: 49.74000
• LogP: 0.18860
• 折射率: 1.47

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : UC3082500 CHEMICAL NAME : 2-Propanone, 1-(methylnitrosoamino)- CAS REGISTRY NUMBER : 55984-51-5 LAST UPDATED : 199707 DATA ITEMS CITED : 22 MOLECULAR FORMULA : C4-H8-N2-O2 MOLECULAR WEIGHT : 116.14 WISWESSER LINE NOTATION : ONN1&1V1 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 35400 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 256 mg/kg/22W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 600 mg/kg/30W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Kidney, Ureter, Bladder - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 176 mg/kg/2ZW-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 68 mg/kg/39W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Sense Organs and Special Senses (Olfaction) - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 94 mg/kg/27W-I TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Sense Organs and Special Senses (Olfaction) - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 800 mg/kg/8W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Gastrointestinal - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 375 mg/kg/30W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 523 mg/kg/23W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Liver - angiosarcoma TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 290 mg/kg/20W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - angiosarcoma TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 36050 ug/kg/2Y-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 300 mg/kg/30W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - hamster DOSE/DURATION : 223 mg/kg/22W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors Liver - tumors TYPE OF TEST : DNA damage TYPE OF TEST : DNA damage MUTATION DATA TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 200 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 40,3463,1980

合成路线

16667-45-1 ~% 55984-51-5

文献：Pei, Guo-Kui; Farnsworth, David W.; Saavedra, Joseph E. Synthetic Communications, 1989 , vol. 19, # 1, 2 p. 207 - 214

79-20-9 62-75-9 ~% 55984-51-5

文献：Seebach,D.; Enders,D. Chemische Berichte, 1975 , vol. 108, p. 1293 - 1320

75411-83-5 ~89% 55984-51-5

文献：Saavedra, Joseph E.; Temu, Caroline T.; Farnsworth, David W. Synthetic Communications, 1989 , vol. 19, # 1, 2 p. 215 - 220

631-57-2 62-75-9 ~% 55984-51-5

文献：Renger,B. et al. Chemische Berichte, 1978 , vol. 111, p. 2630 - 2645

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